Upregulation of heme oxygenase-1 by ginsenoside Ro attenuates lipopolysaccharide-induced inflammation in macrophage cells |
Kim, Sokho
(Department of Laboratory Animal Medicine, Chonbuk National University)
Oh, Myung-Hoon (Department of Laboratory Animal Medicine, Chonbuk National University) Kim, Bum-Seok (Bio-safety Institute, College of Veterinary Medicine, Chonbuk National University) Kim, Won-Il (Bio-safety Institute, College of Veterinary Medicine, Chonbuk National University) Cho, Ho-Seong (Bio-safety Institute, College of Veterinary Medicine, Chonbuk National University) Park, Byoung-Yong (Bio-safety Institute, College of Veterinary Medicine, Chonbuk National University) Park, Chul (Bio-safety Institute, College of Veterinary Medicine, Chonbuk National University) Shin, Gee-Wook (Bio-safety Institute, College of Veterinary Medicine, Chonbuk National University) Kwon, Jungkee (Department of Laboratory Animal Medicine, Chonbuk National University) |
1 | Tsatsanis C, Androulidaki A, Venihaki M, Margioris AN. Signalling networks regulating cyclooxygenase-2. Int J Biochem Cell Biol 2006;38:1654-61. DOI ScienceOn |
2 | McCoubrey Jr WK, Huang TJ, Maines MD. Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3. Eur J Biochem 1997;247:725-32. DOI ScienceOn |
3 | Idriss NK, Blann AD, Lip GY. Hemoxygenase-1 in cardiovascular disease. J Am Coll Cardiol 2008;52:971-8. DOI ScienceOn |
4 | Tsoyi K, Kim HJ, Shin JS, Kim DH, Cho HJ, Lee SS, Ahn SK, Yun-Choi HS, Lee JH, Seo HG, et al. HO-1 and JAK-2/STAT-1 signals are involved in preferential inhibition of iNOS over COX-2 gene expression by newly synthesized tetrahydroisoquinoline alkaloid, CKD712, in cells activated with lipopolysacchride. Cell Signal 2008;20:1839-47. DOI ScienceOn |
5 | Maines MD. Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. FASEB J 1988;2:2557-68. DOI |
6 | Jia L, Zhao Y, Liang XJ. Current evaluation of the millennium phytomedicineginseng (II): collected chemical entities, modern pharmacology, and clinical applications emanated from traditional Chinese medicine. Curr Med Chem 2009;16:2924-42. DOI |
7 | Wang A, Wang CZ, Wu JA, Osinski J, Yuan CS. Determination of major ginsenosides in Panax quinquefolius (American ginseng) using high-performance liquid chromatography. Phytochem Anal 2005;16:272-7. DOI ScienceOn |
8 | Murata K, Takeshita F, Samukawa K, Tani T, Matsuda H. Effects of ginseng rhizome and ginsenoside Ro on testosterone 5alpha-reductase and hair regrowth in testosterone-treated mice. Phytother Res 2012;26:48-53. DOI ScienceOn |
9 | Matsuda H, Samukawa K, Kubo M. Anti-inflammatory activity of ginsenoside Ro. Planta Med 1990;56:19-23. DOI ScienceOn |
10 | Sato K, Balla J, Otterbein L, Smith RN, Brouard S, Lin Y, Csizmadia E, Seviqny J, Robson SC, Vercellotti G, et al. Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants. J Immunol 2001;166:4185-94. DOI |
11 | Matsuda H, Samukawa K, Kubo M. Antihepatitic activity of ginesenoside ro1. Planta Med 1991;57:523-6. DOI ScienceOn |
12 | Murthy HN, Georgiev MI, Kim YS, Jeong CS, Kim SJ, Park SY, et al. Ginsenosides: prospective for sustainable biotechnological production. Appl Microbiol Biotechnol 2014;98:6243-54. DOI ScienceOn |
13 | Zuo Z, Johns RA. Inhalational anesthetics upregulate constitutive and lipopolysaccharide-induced inducible nitric oxide synthase expression and activity. Mol Pharmacol 1997;52:606-12. DOI |
14 | Fujii H, Takahashi T, Nakahira K, Uehara K, Shimizu H, Matsumi M, Morita K, Hirakawa M, Akaqi R, Sassa S. Protective role of heme oxygenase-1 in the intestinal tissue injury in an experimental model of sepsis. Crit Care Med 2003;31:893-902. DOI ScienceOn |
15 | Jun MS, Ha YM, Kim HS, Jang HJ, Kim YM, Lee YS, Kim HJ, Seo HG, Lee JH, Lee SH, et al. Anti-inflammatory action of methanol extract of Carthamus tinctorius involves in heme oxygenase-1 induction. J Ethnopharmacol 2011;133:524-30. DOI ScienceOn |
16 | Motterlini R, Foresti R, Bassi R, Green CJ. Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radic Biol Med 2000;28:1303-12. DOI ScienceOn |
17 | Rossol M, Heine H, Meusch U, Quandt D, Klein C, Sweet MJ, Hauschildt S. LPS-induced cytokine production in human monocytes and macrophages. Crit Rev Immunol 2011;31:379-446. DOI |
18 | Otterbein LE, Soares MP, Yamashita K, Bach FH. Heme oxygenase-1: unleashing the protective properties of heme. Trends Immunol 2003;24:449-55. DOI ScienceOn |
19 | Li QF, Zhu YS, Jiang H, Xu H, Sun Y. Heme oxygenase-1 mediates the anti-inflammatory effect of isoflurane preconditioning in LPS-stimulated macrophages. Acta Pharmacol Sin 2009;30:228-34. DOI ScienceOn |
20 | Ran S, Montgomery KE. Macrophage-mediated lymphangiogenesis: the emerging role of macrophages as lymphatic endothelial progenitors. Cancers (Basel) 2012;4:618-57. DOI ScienceOn |
21 | Nathan C, Xie QW. Nitric oxide synthases: roles, tolls, and controls. Cell 1994;78:915-8. DOI ScienceOn |
22 | Lee SH, Soyoola E, Chanmugam P, Hart S, Sun W, Zhong H, Liou S, Simmons D, Hwang D. Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J Biol Chem 1992;267:25934-8. |
23 | Yu JL, Dou DQ, Chen XH, Yang HZ, Hu XY, Cheng GF. Ginsenoside-Ro enhances cell proliferation and modulates Th1/Th2 cytokines production in murine splenocytes. Yao Xue Xue Bao 2005;40:332-6. |
24 | Pacher P, Beckman JS, Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol Rev 2007;87:315-424. DOI ScienceOn |
25 | Maines MD, Trakshel GM, Kutty RK. Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible. J Biol Chem 1986;261:411-9. |
26 | Gillis CN. Panax ginseng pharmacology: a nitric oxide link? Biochem Pharmacol 1997;54:1-8. DOI ScienceOn |