The inhibitory mechanism of crude saponin fraction from Korean Red Ginseng in collagen-induced platelet aggregation |
Jeon, Bo Ra
(Laboratory of Veterinary Physiology and Cell Signaling, College of Veterinary Medicine, Kyungpook National University)
Kim, Su Jung (Department of Biomedical Laboratory Science, Daegu Health College) Hong, Seung Bok (Department of Clinical Laboratory Science, Chungbuk Health and Science University) Park, Hwa-Jin (Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering and Regional Research Center, Inje University) Cho, Jae Youl (Department of Genetic Engineering, Sungkyunkwan University) Rhee, Man Hee (Laboratory of Veterinary Physiology and Cell Signaling, College of Veterinary Medicine, Kyungpook National University) |
1 | Park HJ, Lee JH, Song YB, Park KH. Effects of dietary supplementation of lipophilic fraction from Panax ginseng on cGMP and cAMP in rat platelets and on blood coagulation. Biol Pharm Bull 1996;19:1434-9. DOI |
2 | Israels SJ, Gerrard JM, Jacques YV, McNicol A, Cham B, Nishibori M, Bainton DF. Platelet dense granule membranes contain both granulophysin and P-selectin (GMP-140). Blood 1992;80:143-52. |
3 | Patrono C, Coller B, FitzGerald GA, Hirsh J, Roth G. Platelet-active drugs: the relationships among dose, effectiveness, and side effects: the Seventh ACCP Conference onAntithrombotic and Thrombolytic Therapy.Chest 2004;126:234S-64S. DOI |
4 | Lee DH, Cho HJ, Kim HH, Rhee MH, Ryu JH, Park HJ. Inhibitory effects of total saponin from Korean Red Ginseng via vasodilator-stimulated phosphoprotein- Ser(157) phosphorylation on thrombin-induced platelet aggregation. J Ginseng Res 2013;37:176-86. DOI |
5 | Pasqui AL, Capecchi PL, Ceccatelli L, Mazza S, Gistri A. Laghi Pasini F, Di Perri T. Nitroprusside in vitro inhibits platelet aggregation and intracellular calcium translocation. Effect of haemoglobin. Thromb Res 1991;61:113-22. |
6 | Schwartz SM, Heimark RL, Majesky MW. Developmental mechanisms underlying pathology of arteries. Physiol Rev 1990;70:1177-209. DOI |
7 | Berridge MJ, Irvine RF. Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature 1984;312:315-21. DOI |
8 | Jennings LK. Role of platelets in atherothrombosis. Am J Cardiol 2009;103:4A-10A. DOI |
9 |
Nishikawa M, Tanaka T, Hidaka H. |
10 | Bhatt DL, Topol EJ. Scientific and therapeutic advances in antiplatelet therapy. Nat Rev Drug Discov 2003;2:15-28. DOI |
11 | Gum PA, Kottke-Marchant K, Welsh PA, White J, Topol EJ. A prospective, blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular disease. J Am Coll Cardiol 2003;41:961-5. DOI |
12 | Jia L, Zhao Y, Liang XJ. Current evaluation of the millennium phytomedicineginseng (II): collected chemical entities, modern pharmacology, and clinical applications emanated from traditional Chinese medicine. Curr Med Chem 2009;16:2924-42. DOI |
13 | Eisert WG. How to get from antiplatelet to antithrombotic treatment. Am J Ther 2001;8:443-9. DOI |
14 | Rezkalla SH, Benz M. Antiplatelet therapy from clinical trials to clinical practice. Clin Med Res 2003;1:101-4. DOI |
15 | Hu FB. Plant-based foods and prevention of cardiovascular disease: an overview. Am J Clin Nutr 2003;78:544S-51S. DOI |
16 | Kim SK, Park JH. Trends in ginseng research in 2010. J Ginseng Res 2011;35: 389-98. DOI |
17 | Kimura Y, Okuda H, Arichi S. Effects of various ginseng saponins on 5- hydroxytryptamine release and aggregation in human platelets. J Pharm Pharmacol 1988;40:838-43. DOI |
18 | Kuo SC, Teng CM, Lee JC, Ko FN, Chen SC, Wu TS. Antiplatelet components in Panax ginseng. Planta Med 1990;56:164-7. DOI |
19 | Lee WM, Kim SD, Park MH, Cho JY, Park HJ, Seo GS, Rhee MH. Inhibitory mechanisms of dihydroginsenoside Rg3 in platelet aggregation: critical roles of ERK2 and cAMP. J Pharm Pharmacol 2008;60:1531-6. DOI |
20 | Lee DH, Cho HJ, Kang HY, Rhee MH, Park HJ. Total saponin from Korean Red Ginseng inhibits thromboxane A2 production associated microsomal enzyme activity in platelets. J Ginseng Res 2012;36:40-6. DOI |
21 | Oh WJ, Endale M, Park SC, Cho JY, Rhee MH. Dual roles of quercetin in platelets: phosphoinositide-3-kinase and MAP kinases inhibition, and cAMPdependent vasodilator-stimulated phosphoprotein stimulation. Evid Based Complement Alternat Med 2012;2012:485262. |
22 | Radad K, Gille G, Liu L, Rausch WD. Use of ginseng in medicine with emphasis on neurodegenerative disorders. J Pharmacol Sci 2006;100:175-86. DOI |
23 | Schaeffer J, Blaustein MP. Platelet free calcium concentrations measured with fura-2 are influenced by the transmembrane sodium gradient. Cell Calcium 1989;10:101-13. DOI |
24 | Jung KY, Kim DS, Oh SR, Lee IS, Lee JJ, Park JD, Kim SI, Lee HK. Platelet activating factor antagonist activity of ginsenosides. Biol Pharm Bull 1998;21:79-80. DOI |
25 | Attele AS, Wu JA, Yuan CS. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol 1999;58:1685-93. DOI |
26 |
Unsworth AJ, Smith H, Gissen P, Watson SP, Pears CJ. Submaximal inhibition of protein kinase C restores ADP-induced dense granule secretion in platelets in the presence of |
27 | Adam F, Kauskot A, Rosa JP, Bryckaert M. Mitogen-activated protein kinases in hemostasis and thrombosis. J Thromb Haemost 2008;6:2007-16. DOI |
28 | Adam F, Kauskot A, Nurden P, Sulpice E, Hoylaerts MF, Davis RJ, Rosa JP, Bryckaert M. Platelet JNK1 is involved in secretion and thrombus formation. Blood 2010;115:4083-92. DOI |
29 | Calderwood DA. Integrin activation. J Cell Sci 2004;117:657-66. DOI |
30 | Ruggeri ZM. Platelets in atherothrombosis. Nat Med 2002;8:1227-34. DOI |
![]() |