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http://dx.doi.org/10.1016/j.jgr.2013.10.001

Protective effect of ginsenoside Re on acute gastric mucosal lesion induced by compound 48/80  

Lee, Sena (College of Korean Medicine, Semyung University)
Kim, Myung-Gyou (College of Korean Medicine, Semyung University)
Ko, Sung Kwon (Department of Oriental Medical Food and Nutrition, Semyung University)
Kim, Hye Kyung (Department of Food and Biotechnology, Hanseo University)
Leem, Kang Hyun (College of Korean Medicine, Semyung University)
Kim, Youn-Jung (College of Nurse Science, Kyung Hee University)
Publication Information
Journal of Ginseng Research / v.38, no.2, 2014 , pp. 89-96 More about this Journal
Abstract
The protective effect of ginsenoside Re, isolated from ginseng berry, against acute gastric mucosal lesions was examined in rats with a single intraperitoneal injection of compound 48/80 (C48/80). Ginsenoside Re (20 mg/kg or 100 mg/kg) was orally administered 0.5 h prior to C48/80 treatment. Ginsenoside Re dose-dependently prevented gastric mucosal lesion development 3 h after C48/80 treatment. Increases in the activities of myeloperoxidase (MPO; an index of neutrophil infiltration) and xanthine oxidase (XO) and the content of thiobarbituric acid reactive substances (TBARS; an index of lipid peroxidation) and decreases in the contents of hexosamine (a marker of gastric mucus) and adherent mucus, which occurred in gastric mucosal tissues after C48/80 treatment, were significantly attenuated by ginsenoside Re. The elevation of Bax expression and the decrease in Bcl2 expression after C48/80 treatment were also attenuated by ginsenoside Re. Ginsenoside Re significantly attenuated all these changes 3 h after C48/80 treatment. These results indicate that orally administered ginsenoside Re protects against C48/80-induced acute gastric mucosal lesions in rats, possibly through its stimulatory action on gastric mucus synthesis and secretion, its inhibitory action on neutrophil infiltration, and enhanced lipid peroxidation in the gastric mucosal tissue.
Keywords
gastritis; ginsenoside Re; mucosa; Panax ginseng;
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