[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.1016/j.jgr.2013.11.011

Metabolomic approach for discrimination of processed ginseng genus (Panax ginseng and Panax quinquefolius) using UPLC-QTOF MS

Park, Hee-Won (Korea Ginseng Corporation Research Institute, Korea Ginseng Corporation)
In, Gyo (Korea Ginseng Corporation Research Institute, Korea Ginseng Corporation)
Kim, Jeong-Han (Department of Agricultural Biotechnology, Seoul National University)
Cho, Byung-Goo (Korea Ginseng Corporation Research Institute, Korea Ginseng Corporation)
Han, Gyeong-Ho (Korea Ginseng Corporation Research Institute, Korea Ginseng Corporation)
Chang, Il-Moo (Korea Ginseng Corporation Research Institute, Korea Ginseng Corporation)

Publication Information

Journal of Ginseng Research / v.38, no.1, 2014 , pp. 59-65 More about this Journal

Abstract

Discriminating between two herbal medicines (Panax ginseng and Panax quinquefolius), with similar chemical and physical properties but different therapeutic effects, is a very serious and difficult problem. Differentiation between two processed ginseng genera is even more difficult because the characteristics of their appearance are very similar. An ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF MS)-based metabolomic technique was applied for the metabolite profiling of 40 processed P. ginseng and processed P. quinquefolius. Currently known biomarkers such as ginsenoside Rf and F11 have been used for the analysis using the UPLC-photodiode array detector. However, this method was not able to fully discriminate between the two processed ginseng genera. Thus, an optimized UPLC-QTOF-based metabolic profiling method was adapted for the analysis and evaluation of two processed ginseng genera. As a result, all known biomarkers were identified by the proposed metabolomics, and additional potential biomarkers were extracted from the huge amounts of global analysis data. Therefore, it is expected that such metabolomics techniques would be widely applied to the ginseng research field.

Keywords

discrimination; metabolomics; Panax ginseng; Panax quinquefolius; UPLC-QTOF MS;

Citations & Related Records

Times Cited By KSCI : 5 (Citation Analysis)

Reference
Cited By KSCI

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