Ginsenoside Rd inhibits the expressions of iNOS and COX-2 by suppressing NF-κB in LPS-stimulated RAW264.7 cells and mouse liver |
Kim, Dae Hyun
(Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University)
Chung, Jae Heun (Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University) Yoon, Ji Sung (Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University) Ha, Young Mi (Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University) Bae, Sungjin (Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University) Lee, Eun Kyeong (Research Center, Dongnam Institute of Radiological and Medical Sciences) Jung, Kyung Jin (Inhalation Toxicology Center, Korea Institute of Toxicology) Kim, Min Sun (Department of Pharmacy, College of Pharmacy, Sunchon National University) Kim, You Jung (Department of Dental Hygiene, Busan Women's College) Kim, Mi Kyung (Longevity Life Science and Technology Institute, Pusan National University) Chung, Hae Young (Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University) |
1 | Kim JW, Zou Y, Yoon S, Lee JH, Kim YK, Yu BP, Chung HY. Vascular aging: molecular modulation of the prostanoid cascade by calorie restriction. J Gerontol A Biol Sci Med Sci 2004;59:B876-B885. DOI |
2 | Baek BS, Kim JW, Lee JH, Kwon HJ, Kim ND, Kang HS, Yoo MA, Yu BP, Chung HY. Age-related increase of brain cyclooxygenase activity and dietary modulation of oxidative status. J Gerontol A Biol Sci Med Sci 2001;56:B426-B431. DOI |
3 | Park EK, Shin YW, Lee HU, Kim SS, Lee YC, Lee BY, Kim DH. Inhibitory effect of ginsenoside Rb1 and compound K on NO and prostaglandin E2 biosyntheses of RAW264.7 cells induced by lipopolysaccharide. Biol Pharm Bull 2005;28:652-656. DOI ScienceOn |
4 | Napoli C, de Nigris F, Williams-Ignarro S, Pignalosa O, Sica V, Ignarro LJ. Nitric oxide and atherosclerosis: an update. Nitric Oxide 2006;15:265-279. DOI ScienceOn |
5 | Giuliano F, Warner TD. Origins of prostaglandin E2: involvements of cyclooxygenase (COX)-1 and COX-2 in human and rat systems. J Pharmacol Exp Ther 2002; 303:1001-1006. DOI ScienceOn |
6 | Yamada M, Niki H, Yamashita M, Mue S, Ohuchi K. Prostaglandin E2 production dependent upon cyclooxygenase-1 and cyclooxygenase-2 and its contradictory modulation by auranofin in rat peritoneal macrophages. J Pharmacol Exp Ther 1997;281:1005-1012. |
7 | Bayon Y, Ortiz MA, Lopez-Hernandez FJ, Gao F, Karin M, Pfahl M, Piedrafita FJ. Inhibition of IkappaB kinase by a new class of retinoid-related anticancer agents that induce apoptosis. Mol Cell Biol 2003;23:1061-1074. DOI |
8 | Yu BP, Chung HY. Oxidative stress and vascular aging. Diabetes Res Clin Pract 2001;54 Suppl 2:S73-S80. DOI ScienceOn |
9 | Cuzzocrea S. Role of nitric oxide and reactive oxygen species in arthritis. Curr Pharm Des 2006;12:3551-3570. DOI ScienceOn |
10 | Marriott HM, Ali F, Read RC, Mitchell TJ, Whyte MK, Dockrell DH. Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infection. FASEB J 2004;18:1126-1128. DOI |
11 | Chung HY, Sung B, Jung KJ, Zou Y, Yu BP. The molecular inflammatory process in aging. Antioxid Redox Signal 2006;8:572-581. DOI ScienceOn |
12 | Lee C, Miura K, Liu X, Zweier JL. Biphasic regulation of leukocyte superoxide generation by nitric oxide and peroxynitrite. J Biol Chem 2000;275:38965-38972. DOI ScienceOn |
13 | Yadav PN, Liu Z, Rafi MM. A diarylheptanoid from lesser galangal (Alpinia officinarum) inhibits proinflammatory mediators via inhibition of mitogen-activated protein kinase, p44/42, and transcription factor nuclear factor-kappa B. J Pharmacol Exp Ther 2003;305:925-931. DOI ScienceOn |
14 | Rose P, Won YK, Ong CN, Whiteman M. Beta-phenylethyl and 8-methylsulphinyloctyl isothiocyanates, constituents of watercress, suppress LPS induced production of nitric oxide and prostaglandin E2 in RAW264.7 Macrophages. Nitric Oxide 2005;12:237-243. DOI ScienceOn |
15 | Wakabayashi C, Hasegawa H, Murata J, Saiki I. In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration. Oncol Res 1997;9:411-417. |
16 | Karin M, Cao Y, Greten FR, Li ZW. NF-kappaB in cancer: from innocent bystander to major culprit. Nat Rev Cancer 2002;2:301-310. DOI ScienceOn |
17 | Hilmy M, Campbell R, Bartlett JM, McNicol AM, Underwood MA, McMillan DC. The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic infiltration and COX-2 expression and survival in patients with transitional cell carcinoma of the urinary bladder. Br J Cancer 2006;95:1234-1238. DOI ScienceOn |
18 | Shang W, Yang Y, Jiang B, Jin H, Zhou L, Liu S, Chen M. Ginsenoside Rb1 promotes adipogenesis in 3T3-L1 cells by enhancing PPARgamma2 and C/EBPalpha gene expression. Life Sci 2007;80:618-625. DOI ScienceOn |
19 | Xie JT, Shao ZH, Vanden Hoek TL, Chang WT, Li J, Mehendale S, Wang CZ, Hsu CW, Becker LB, Yin JJ et al. Antioxidant effects of ginsenoside Re in cardiomyocytes. Eur J Pharmacol 2006;532:201-207. DOI ScienceOn |
20 | Park EK, Choo MK, Han MJ, Kim DH. Ginsenoside Rh1 possesses antiallergic and anti-inflammatory activities. Int Arch Allergy Immunol 2004;133:113-120. DOI ScienceOn |
21 | Choi SS, Lee JK, Han EJ, Han KJ, Lee HK, Lee J, Suh HW. Effect of ginsenoside Rd on nitric oxide system induced by lipopolysaccharide plus TNF-alpha in C6 rat glioma cells. Arch Pharm Res 2003;26:375-382. DOI ScienceOn |
22 | Yokozawa T, Satoh A, Cho EJ. Ginsenoside-Rd attenuates oxidative damage related to aging in senescence-accelerated mice. J Pharm Pharmacol 2004;56:107-113. DOI ScienceOn |
23 | Kimura S, Watanabe K, Yajiri Y, Motegi T, Masuya Y, Shibuki K, Uchiyama S, Homma T, Takahashi HE. Cerebrospinal fluid nitric oxide metabolites in painful diseases. Neuroreport 1999;10:275-279. DOI ScienceOn |
24 | Lee YN, Lee HY, Lee YM, Chung HY, Kim SI, Lee SK, Park BC, Kim KW. Involvement of glucocorticoid receptor in the induction of differentiation by ginsenosides in F9 teratocarcinoma cells. J Steroid Biochem Mol Biol 1998;67:105-111. DOI ScienceOn |
25 | Kerr LD. Electrophoretic mobility shift assay. Methods Enzymol 1995;254:619-632. DOI |
26 | Kim HJ, Kim KW, Yu BP, Chung HY. The effect of age on cyclooxygenase-2 gene expression: NF-kappaB activation and IkappaBalpha degradation. Free Radic Biol Med 2000;28:683-692. DOI ScienceOn |
27 | Soloviev A, Lehen’kyi V, Zelensky S, Hellstrand P. Nitric oxide relaxes rat tail artery smooth muscle by cyclic GMP-independent decrease in calcium sensitivity of myofilaments. Cell Calcium 2004;36:165-173. DOI ScienceOn |
28 | Karin M, Lin A. NF-kappaB at the crossroads of life and death. Nat Immunol 2002;3:221-227. |
29 | Li Q, Verma IM. NF-kappaB regulation in the immune system. Nat Rev Immunol 2002;2:725-734. DOI ScienceOn |
30 | Adams J, Stein R. Novel inhibitors of the proteasome and their therapeutic use in inflammation. Annu Rep Med Chem 1996;31:279-288. DOI |
31 | Chen YQ, Ghosh S, Ghosh G. A novel DNA recognition mode by the NF-kappa B p65 homodimer. Nat Struct Biol 1998;5:67-73. DOI ScienceOn |
32 | Baldwin AS Jr. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 1996;14:649-683. DOI ScienceOn |
33 | Kitagawa I, Yoshikawa M, Yoshihara M, Hayashi T, Taniyama T. Chemical studies of crude drugs (1). Constituents of ginseng radix rubra. Yakugaku Zasshi 1983;103:612-622. DOI |
34 | Mann JR, Backlund MG, DuBois RN. Mechanisms of disease: inflammatory mediators and cancer prevention. Nat Clin Pract Oncol 2005;2:202-210. |
35 |
Song SB, Tung NH, Quang TH, Ngan NT, Kim KE, Kim YH: Inhibition of TNF- |
36 | Shen T, Lee J, Park MH, Lee YG, Rho HS, Kwak YS, Rhee MH, Park YC, Cho JY: Ginsenoside Rp1, a ginsenoside derivative, blocks promoter activation of iNOS and COX-2 genes by suppression of an IKKb-mediated NF-kB pathway in HEK293 cells. J Ginseng Res 2011; 35:200-208. DOI ScienceOn |
37 | Kim H, Lee HS, Chang KT, Ko TH, Baek KJ, Kwon NS. Chloromethyl ketones block induction of nitric oxide synthase in murine macrophages by preventing activation of nuclear factor-kappa B. J Immunol 1995;154:4741-4748. |
38 | Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-685. DOI ScienceOn |
39 | Hwang BY, Lee JH, Koo TH, Kim HS, Hong YS, Ro JS, Lee KS, Lee JJ. Furanoligularenone, an eremophilane from Ligularia fischeri, inhibits the LPS-induced production of nitric oxide and prostaglandin E2 in macrophage RAW264.7 cells. Planta Med 2002;68:101-105. DOI ScienceOn |
40 | Go EK, Jung KJ, Kim JM, Lim H, Lim HK, Yu BP, Chung HY. Betaine modulates age-related NF-kappaB by thiol-enhancing action. Biol Pharm Bull 2007;30:2244-2249. DOI ScienceOn |
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