Enzymatic Biotransformation of Ginsenoside Rb1 and Gypenoside XVII into Ginsenosides Rd and F2 by Recombinant β-glucosidase from Flavobacterium johnsoniae |
Hong, Hao
(KAIST Institute for Biocentury, Korea Advanced Institute of Science and Technology)
Cui, Chang-Hao (KAIST Institute for Biocentury, Korea Advanced Institute of Science and Technology) Kim, Jin-Kwang (KAIST Institute for Biocentury, Korea Advanced Institute of Science and Technology) Jin, Feng-Xie (College of Biotechnology, Dalian Polytechnic University) Kim, Sun-Chang (KAIST Institute for Biocentury, Korea Advanced Institute of Science and Technology) Im, Wan-Taek (KAIST Institute for Biocentury, Korea Advanced Institute of Science and Technology) |
1 | Wu L, Jin Y, Yin C, Bai L. Co-transformation of Panax major ginsenosides Rb1 and Rg1 to minor ginsenosides C-K and F1 by Cladosporium cladosporioides. J Ind Microbiol Biotechnol 2012;39:521-527. DOI ScienceOn |
2 | Kim BN, Yeom SJ, Kim YS, Oh DK. Characterization of a -glucosidase from Sulfolobus solfataricus for isoflavone glycosides. Biotechnol Lett 2012;34:125-129. DOI |
3 | Kim S, Nah SY, Rhim H. Neuroprotective effects of ginseng saponins against L-type channel-mediated cell death in rat cortical neurons. Biochem Biophys Res Commun 2008;365:399-405. DOI ScienceOn |
4 | Shin JY, Lee JM, Shin HS, Park SY, Yang JE, Cho SK, Yi TH. Anti-cancer effect of ginsenoside F2 against glioblastoma multiforme in xenograft model in SD rats. J Ginseng Res 2012;36:86-92. DOI ScienceOn |
5 | Guan YY, Zhou JG, Zhang Z, Wang GL, Cai BX, Hong L, Qiu QY, He H. Ginsenoside-Rd from Panax notoginseng blocks influx through receptor- and store-operated channels in vascular smooth muscle cells. Eur J Pharmacol 2006;548:129-136. DOI ScienceOn |
6 | Lee JK, Choi SS, Lee HK, Han KJ, Han EJ, Suh HW. Effects of ginsenoside Rd and decursinol on the neurotoxic responses induced by kainic acid in mice. Planta Med 2003;69:230-234. DOI ScienceOn |
7 | Yang ZG, Sun HX, Ye YP. Ginsenoside Rd from Panax notoginseng is cytotoxic towards HeLa cancer cells and induces apoptosis. Chem Biodivers 2006;3:187-197. DOI ScienceOn |
8 | Cheng LQ, Na JR, Kim MK, Bang MH, Yang DC. Microbial conversion of ginsenoside Rb1 to minor ginsenoside F2 and gypenoside XVII by Intrasporangium sp. GS603 isolated from soil. J Microbiol Biotechnol 2007;17:1937-1943. |
9 | Park CS, Yoo MH, Noh KH, Oh DK. Biotransformation of ginsenosides by hydrolyzing the sugar moieties of ginsenosides using microbial glycosidases. Appl Microbiol Biotechnol 2010;87:9-19. DOI |
10 | Quan LH, Min JW, Yang DU, Kim YJ, Yang DC. Enzymatic biotransformation of ginsenoside Rb1 to 20(S)-Rg3 by recombinant -glucosidase from Microbacterium esteraromaticum. Appl Microbiol Biotechnol 2012;94:377-384. DOI ScienceOn |
11 | Quan LH, Min JW, Sathiyamoorthy S, Yang DU, Kim YJ, Yang DC. Biotransformation of ginsenosides Re and Rg1 into ginsenosides Rg2 and Rh1 by recombinant -glucosidase. Biotechnol Lett 2012;34:913-917. DOI ScienceOn |
12 | An DS, Cui CH, Lee HG, Wang L, Kim SC, Lee ST, Jin F, Yu H, Chin YW, Lee HK et al. Identifi cation and characterization of a novel Terrabacter ginsenosidimutans sp. nov. beta-glucosidase that transforms ginsenoside Rb1 into the rare gypenosides XVII and LXXV. Appl Environ Microbiol 2010;76:5827-5836. DOI ScienceOn |
13 | Yan Q, Zhou W, Li X, Feng M, Zhou P. Purification method improvement and characterization of a novel ginsenoside-hydrolyzing beta-glucosidase from Paecilomyces Bainier sp. 229. Biosci Biotechnol Biochem 2008;72:352-359. DOI ScienceOn |
14 | Son JW, Kim HJ, Oh DK. Ginsenoside Rd production from the major ginsenoside Rb1 by beta-glucosidase from Thermus caldophilus. Biotechnol Lett 2008;30:713-716. DOI |
15 | Noh KH, Son JW, Kim HJ, Oh DK. Ginsenoside compound K production from ginseng root extract by a thermostable beta-glycosidase from Sulfolobus solfataricus. Biosci Biotechnol Biochem 2009;73:316-321. DOI ScienceOn |
16 | Ye L, Zhou CQ, Zhou W, Zhou P, Chen DF, Liu XH, Shi XL, Feng MQ. Biotransformation of ginsenoside Rb1 to ginsenoside Rd by highly substrate-tolerant Paecilomyces Bainier 229-7. Bioresour Technol 2010;101:7872-7876. DOI ScienceOn |
17 | Chi H, Ji GE. Transformation of ginsenosides Rb1 and Re from Panax ginseng by food microorganisms. Biotechnol Lett 2005;27:765-771. DOI ScienceOn |
18 | Keum YS, Han SS, Chun KS, Park KK, Park JH, Lee SK, Surh YJ. Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-kappaB activation and tumor promotion. Mutat Res 2003;523-524:75-85. DOI ScienceOn |
19 | Kim MH, Lee YC, Choi SY, Cho CW, Rho J, Lee KW. The changes of ginsenoside patterns in red ginseng processed by organic acid impregnation pretreatment. J Ginseng Res 2011;35:497-503. 과학기술학회마을 DOI ScienceOn |
20 | Ernst E. Panax ginseng: An overview of the clinical evidence. J Ginseng Res 2010;34:259-263. 과학기술학회마을 DOI ScienceOn |
21 | Wang L, Liu QM, Sung BH, An DS, Lee HG, Kim SG, Kim SC, Lee ST, Im WT. Bioconversion of ginsenosides Rb1, Rb2, Rc and Rd by novel -glucosidase hydrolyzing outer 3-O glycoside from Sphingomonas sp. 2F2: cloning, expression, and enzyme characterization. J Biotechnol 2011;156:125-133. DOI ScienceOn |
22 | Wang DM, Yu HS, Song JG, Xu YF, Jin FX. Enzyme kinetics of ginsenosidase type IV hydrolyzing 6-O-multiglycosides of protopanaxatriol type ginsenosides. Process Biochem 2012;47:133-138. DOI ScienceOn |
23 | Tawab MA, Bahr U, Karas M, Wurglics M, Schubert-Zsilavecz M. Degradation of ginsenosides in humans after oral administration. Drug Metab Dispos 2003;31:1065-1071. DOI ScienceOn |
24 | Akao T, Kida H, Kanaoka M, Hattori M, Kobashi K. Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng. J Pharm Pharmacol 1998;50:1155-1160. DOI |
25 | Kim HS, Lee EH, Ko SR, Choi KJ, Park JH, Im DS. Effects of ginsenosides Rg3 and Rh2 on the proliferation of prostate cancer cells. Arch Pharm Res 2004;27:429-435. DOI ScienceOn |