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http://dx.doi.org/10.5142/jgr.2012.36.2.176

Efficacy of Korean Red Ginseng by Single Nucleotide Polymorphism in Obese Women: Randomized, Double-blind, Placebo-controlled Trial  

Kwon, Dong-Hyun (Department of Oriental Rehabilitation Medicine, Dongguk University)
Bose, Shambhunath (Department of Oriental Rehabilitation Medicine, Dongguk University)
Song, Mi-Young (Department of Oriental Rehabilitation Medicine, Dongguk University)
Lee, Myeong-Jong (Department of Oriental Rehabilitation Medicine, Dongguk University)
Lim, Chi-Yeon (Department of Medicine, Dongguk University)
Kwon, Bum-Sun (Department of Physical Medicine and Rehabilitation, Dongguk University)
Kim, Ho-Jun (Department of Oriental Rehabilitation Medicine, Dongguk University)
Publication Information
Journal of Ginseng Research / v.36, no.2, 2012 , pp. 176-189 More about this Journal
Abstract
This study examined the effects of Korean red ginseng (KRG) on obese women and aimed to confirm that the effects of KRG on obesity differ dependently on a gene. Fifty obese women were recruited and randomized to receive KRG (n=24) or placebo (n=26) for 8 wk. Measurements of blood pressure, height, weight, waist circumference, waist-hip ratio (WHR), total fat mass, percentage of body fat, resting metabolic rate, basal body temperature, and daily food intake (FI), blood test (serum lipid, liver and renal function), Korean version of obesity-related quality of life scale (KOQOL), and a gene examination were performed. Comparisons of subjects before and after the administration of KRG revealed significant improvements of obesity in terms of weight, body mass index (BMI), WHR, FI, and KOQOL. However, in the comparison between KRG group and placebo group, only KOQOL was significantly different. KRG displayed significant efficacy on BMI and KOQOL in the CT genotype of the G protein beta 3 gene, but not in the CC genotype, on blood sugar test in the Trp64/Arg genotype of the beta 3 adrenergic receptor gene, but not in Trp64/Trp genotype, on KOQOL in the DD genotype of the angiotensin I converting enzyme gene, but not in the ID and DD genotypes. The effects of KRG on obesity were confirmed to some extent. However, a distinct effect compared to placebo was not confirmed. KRG is more effective for improving the secondary issues of the quality of life derived from obesity rather than having direct effects on the obesity-related anthropometric assessment and blood test indices.
Keywords
Panax ginseng; Korean red ginseng; Obesity; Genetic polymorphism; Single nucleotide polymorphism;
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1 Cheon WK, Kim KJ. Association of mutation in the beta- 3 adrenergic receptor gene with obesity response to diet plus exercise intervention in middle-aged women. Korean J Exerc Nutr 2007;11:41-48.
2 Seo YS, Kim DH , Lee IG, Lee GM , Kim YH. Effect of variants of the $\beta$-3 adrenergic receptor and the leptin receptor gene on weight loss. Korean J Obes 2003;12:294-303.
3 Gayagay G, Yu B, Hambly B, Boston T, Hahn A, Celermajer DS, Trent RJ. Elite endurance athletes and the ACE I allele: the role of genes in athletic performance. Hum Genet 1998;103:48-50.   DOI
4 Lee YJ, Tsai JC. ACE gene insertion/deletion polymorphism associated with 1998 World Health Organization defi nition of metabolic syndrome in Chinese type 2 diabetic patients. Diabetes Care 2002;25:1002-1008.   DOI   ScienceOn
5 Cooper R, McFarlane-Anderson N, Bennett FI, Wilks R, Puras A, Tewksbury D, Ward R, Forrester T. ACE, angiotensinogen and obesity: a potential pathway leading to hypertension. J Hum Hypertens 1997;11:107-111.   DOI
6 Lee SJ, You JH, Lee JK. A study of characteristics on health-related physical fi tness factors and blood variables according to ACE I/D polymorphism in mid-life obese women. Korean J Exerc Nutr 2007;11:207-212.
7 Seo HN, Kim YJ, Moon SJ, Jeong JG. Effects of aerobic excercise on ACE and risk factors of cardiovascular system of middle-aged women according to the existence and nonexistence of metabolic syndrome. Korean J Sports Sci 2010;19:1275-1286.
8 Ham YG. Effects of ACE gene polymorphism and dance sports on blood pressure. Korean J Exerc Nutr 2008;12:133-137.
9 Jung SJ, Ahn NY, Hong CB, Park JH, Park JS, Kim KJ. Comparisons of body composition, physical fitness and combined exercise training mediate changes according to ACE I/D polymorphism in elementary students. Korean J Growth Dev 2009;17:259-266.
10 Zeltner R, Delles C, Schneider M, Siffert W, Schmieder RE. G-protein beta(3) subunit gene (GNB3) 825T allele is associated with enhanced renal perfusion in early hypertension. Hypertension 2001;37:882-886.   DOI
11 Woo SG, Jung SH, Han TK. Effect of an aerobic exercise on obesity and metabolic syndrome markers across the GNB3 C825T genotype in obesity middle age women. J Korean Soc Living Environ Syst 2008;15:392-399.
12 Kang HS, Lee JY, Han TK. Relationship of the GNB3 C825T gene polymorphism with the metabolic syndrome markers in mid-life women. Korean J Sport Sci 2006;17:1-8.
13 Giacobino JP. Beta 3-adrenoceptor: an update. Eur J Endocrinol 1995;132:377-385.   DOI
14 Lowell BB, Flier JS. Brown adipose tissue, beta 3-adrenergic receptors, and obesity. Annu Rev Med 1997;48:307-316.   DOI   ScienceOn
15 Choi WH. Role of beta3 adrenreceptor. Korean J Obes 2001;10:205-216.
16 Walston J, Silver K, Bogardus C, Knowler WC, Celi FS, Austin S, Manning B, Strosberg AD, Stern MP, Raben N et al. Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergicreceptor gene. N Engl J Med 1995;333:343-347.   DOI   ScienceOn
17 Walston J, Silver K, Bogardus C, Knowler WC, Celi FS, Austin S, Manning B, Strosberg AD, Stern MP, Raben N et al. Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergicreceptor gene. N Engl J Med 1995;333:343-347.   DOI   ScienceOn
18 Clement K, Vaisse C, Manning BS, Basdevant A, Guy- Grand B, Ruiz J, Silver KD, Shuldiner AR, Froguel P, Strosberg AD. Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. N Engl J Med 1995;333:352-354.   DOI   ScienceOn
19 Park HJ, Lee JH, Lee SJ, Ham HS, Cho HJ, Lim CR, Yoo YB, Park KH. Effects of intaking of red ginseng products on correlationship between obesity and blood lipids. Korean J Biomed Lab Sci 2000;6:253-260.
20 Silver K, Mitchell BD, Walston J, Sorkin JD, Stern MP, Roth J, Shuldiner AR. TRP64ARG beta 3-adrenergic receptor and obesity in Mexican Americans. Hum Genet 1997;101:306-311.   DOI
21 Han YJ, Kim JH. Effect of crude saponin of Korea red ginseng on high fat diet-induced obese rats. J Korean Orient Med 2006;27:1-13.
22 Kim SS, Kim JD, Kim H, Shin MS, Park CK, Park MH, Yang JW. The effects of red ginseng product and combined exercise on blood lipids and body composition of obese women in their twenties. J Ginseng Res 2002;26:59-66.   DOI   ScienceOn
23 Seong JH, So NU, Jeon BH, Jang JC. Effect of white and red Panax ginseng extract on serum lipids level in highfat-diet fed rats. J Ginseng Res 2004;28:33-38.   DOI   ScienceOn
24 Oh SJ, Kim YS, Park CY, Kim SW, Yang IM, Kim JW, Choi YK, Paeng JR, Shin HD. Body fat decreasing mechanisms of red ginseng compound. Korean J Obes 2000;9:209-218.
25 Park HS, Sung SW, Ou SW, Lee KY, Kim BS, Han JH, Kim SM, Lee HR, Yu BY, Lee KM et al. Development of Korean version of obesity-related quality of life scale. Korean J Obes 2003;12:280-293.
26 Kim SI, Kim YS, Jeon BS, Lim CH. Effect of ginseng on fat accumulation in the obese rats induced by high fat diet. Korean J Ginseng Sci 1986;10:167-179.
27 Kim SS, Park HY, Byun YH, Hwang BG, Lee JH, Shim YJ, Park CK, Park MH, Yang JW. The effects on the blood lipid profi les and body fat by long term administration of red ginseng product. J Ginseng Res 2002;26:63-73.
28 Ohshiro Y, Ueda K, Wakasaki H, Takasu N, Nanjo K. Analysis of 825C/T polymorphism of G proteinbeta3 subunit in obese/diabetic Japanese. Biochem Biophys Res Commun 2001;286:678-680.   DOI   ScienceOn
29 Kim MS. Modulation factors of energy metabolism. Korean J Obes 2000;9:6-11.
30 Choi H, Bae HS, Hong MC, Shin HD, Shin MK. Study of gene-gene interaction within GNB3, ACE, ADRB3, ADRB2 among Korean female subject. Korean J Orient Med Physiol Pathol 2004;18:1426-1436.
31 Hong SK. Energy balance and obesity. Korean J Obes 2000;9:1-5.
32 Kim SJ, Shin SW, Kim HJ. Obesity from the view point of metabolic rate. J Korean Orient Assoc Stud Obes 2003;3:95-105.
33 Beck SH. Obesity related gene variations. Korean J Obes 2004;13:221-229.
34 Association of School of Herbology. Herbology. Seoul: Younglim, 2000.
35 Hong B, Ji YH, Hong JH, Nam KY, Ahn TY. A doubleblind crossover study evaluating the efficacy of Korean red ginseng in patients with erectile dysfunction: a preliminary report. J Urol 2002;168:2070-2073.   DOI   ScienceOn
36 Sung H, Jung YS, Cho YK. Beneficial effects of a combination of Korean red ginseng and highly active antiretroviral therapy in human immunodeficiency virus type 1-infected patients. Clin Vaccine Immunol 2009;16:1127-1131.   DOI   ScienceOn
37 Suh SO, Kroh M, Kim NR, Joh YG, Cho MY. Effects of red ginseng upon postoperative immunity and survival in patients with stage III gastric cancer. Am J Chin Med 2002;30:483-494.   DOI   ScienceOn