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http://dx.doi.org/10.5142/jgr.2012.36.1.61

Processed Panax ginseng, Sun Ginseng Increases Type I Collagen by Regulating MMP-1 and TIMP-1 Expression in Human Dermal Fibroblasts  

Song, Kyu-Choon (Lab of Cell Differentiation Research, College of Oriental Medicine, Gachon University)
Chang, Tong-Shin (Division of Life & Pharmaceutical Sciences, Center for Cell Signaling & Drug Discovery Research, College of Pharmacy, Ewha Womans University)
Lee, Hye-Jin (Lab of Cell Differentiation Research, College of Oriental Medicine, Gachon University)
Kim, Jin-Hee (Lab of Cell Differentiation Research, College of Oriental Medicine, Gachon University)
Park, Jeong-Hill (College of Pharmacy, Seoul National University)
Hwang, Gwi-Seo (Lab of Cell Differentiation Research, College of Oriental Medicine, Gachon University)
Publication Information
Journal of Ginseng Research / v.36, no.1, 2012 , pp. 61-67 More about this Journal
Abstract
In the present study, effects of sun ginseng (SG) on the collagen synthesis and the proliferation of dermal fibroblast were investigated. Collagen synthesis was measured by assaying procollagen type I C-peptide production. In addition, the level of matrix metalloproteinase (MMP)-1 was assessed by western blot analysis. SG suppressed the MMP-1 protein level in a dose-dependent manner. In contrast, SG dose-dependently increased tissue inhibitors of MMP (TIMP)-1 production in fibroblasts. SG increased type I collagen production directly and/or indirectly by reducing MMP-1 and stimulating TIMP-1 production in human dermal fibroblasts. SG dose-dependently induced fibroblast proliferation and this, in turn, can trigger more collagen production. These results suggest that SG may be a potential pharmacological agent with anti-aging properties in cultured human skin fibroblast.
Keywords
Panax ginseng; Sun ginseng (SE); Type I collagen; Matrix metalloproteinase-1; Human skin fibroblasts;
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Times Cited By Web Of Science : 3  (Related Records In Web of Science)
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