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http://dx.doi.org/10.5142/jgr.2011.35.4.457

Improvement of Cognitive Deficit in Alzheimer's Disease Patients by Long Term Treatment with Korean Red Ginseng  

Heo, Jae-Hyeok (Department of Neurology, Seoul Medical Center)
Lee, Soon-Tae (Department of Neurology, Seoul National University Hospital)
Oh, Min-Jung (Department of Neurology, Seoul National University Hospital)
Park, Hyun-Jung (Department of Neurology, Seoul National University Hospital)
Shim, Ji-Young (Department of Neurology, Seoul National University Hospital)
Chu, Kon (Department of Neurology, Seoul National University Hospital)
Kim, Man-Ho (Department of Neurology, Seoul National University Hospital)
Publication Information
Journal of Ginseng Research / v.35, no.4, 2011 , pp. 457-461 More about this Journal
Abstract
A 24-week randomized open-label study with Korean red ginseng (KRG) showed cognitive benefits in patients with Alzheimer's disease. To further determine long-term effect of KRG, the subjects were recruited to be followed up to 2 yr. Cognitive function was evaluated every 12 wk using the Alzheimer's Disease Assessment Scale (ADAS) and the Korean version of the Mini Mental Status Examination (K-MMSE) with the maintaining dose of 4.5 g or 9.0 g KRG per d. At 24 wk, there had been a significant improvement in KRG-treated groups. In the long-term evaluation of the efficacy of KRG after 24 wk, the improved MMSE score remained without significant decline at the 48th and 96th wk. ADAS-cog showed similar findings. Maximum improvement was found around week 24. In conclusion, the effect of KRG on cognitive functions was sustained for 2 yr follow-up, indicating feasible efficacies of long-term follow-up for Alzheimer's disease.
Keywords
Panax ginseng; Korean red ginseng; Alzheimer disease; Long term effect;
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1 Liu L, Hoang-Gia T, Wu H, Lee MR, Gu L, Wang C, Yun BS, Wang Q, Ye S, Sung CK. Ginsenoside $Rb_1$ improves spatial learning and memory by regulation of cell genesis in the hippocampal subregions of rats. Brain Res 2011;1382:147-154.   DOI   ScienceOn
2 Zhao R, Zhang Z, Song Y, Wang D, Qi J, Wen S. Implication of phosphatidylinositol-3 kinase/Akt/glycogen synthase kinase-3$\beta$ pathway in ginsenoside $Rb_1$'s attenuation of beta-amyloid-induced neurotoxicity and tau phosphorylation. J Ethnopharmacol 2011;133:1109-1116.   DOI   ScienceOn
3 Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M, Hall K, Hasegawa K, Hendrie H, Huang Y et al. Global prevalence of dementia: a Delphi consensus study. Lancet 2005;366:2112-2117.   DOI
4 Wisniewski T. Is amyloid-$\beta$-peptide immunization clinically effective in patients with Alzheimer's disease? Nat Clin Pract Neurol 2005;1:84-85.   DOI
5 Akhondzadeh S, Abbasi SH. Herbal medicine in the treatment of Alzheimer's disease. Am J Alzheimers Dis Other Demen 2006;21:113-118.   DOI
6 Sorensen H, Sonne J. A double-masked study of the effects of ginseng on cognitive functions. Curr Ther Res 1996;57:959-968.   DOI   ScienceOn
7 Scholey A, Ossoukhova A, Owen L, Ibarra A, Pipingas A, He K, Roller M, Stough C. Effects of American ginseng (Panax quinquefolius) on neurocognitive function: an acute, randomised, double-blind, placebo-controlled, crossover study. Psychopharmacology (Berl) 2010;212:345-356.   DOI
8 Lee ST, Chu K, Sim JY, Heo JH, Kim M. Panax ginseng enhances cognitive performance in Alzheimer disease. Alzheimer Dis Assoc Disord 2008;22:222-226.   DOI   ScienceOn
9 Zhang JT, Liu Y, Qu ZW, Zhang XL, Xiao HL. Influence of ginsenoside Rb1 and Rg1 on some central neurotransmitter receptors and protein biosynthesis in the mouse brain. Yao Xue Xue Bao 1988;23:12-16.
10 Ying Y, Zhang JT, Shi CZ, Qu ZW, Liu Y. Study on the nootropic mechanism of ginsenoside Rb1 and Rg1: influence on mouse brain development. Yao Xue Xue Bao 1994;29:241-245.
11 Heo JH, Lee ST, Chu K, Oh MJ, Park HJ, Shim JY, Kim M. An open-label trial of Korean red ginseng as an adjuvant treatment for cognitive impairment in patients with Alzheimer's disease. Eur J Neurol 2008;15:865-868.   DOI   ScienceOn
12 Minthon L, Wallin AK, Eriksson S, Wattmo C, Andreasen N. Long-term rivastigmine treatment in a routine clinical setting. Acta Neurol Scand 2009;119:180-185.
13 McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-944.   DOI
14 Nam KY. The comparative understanding between red ginseng and white ginsengs, processed ginsengs (Panax ginseng C.A. Meyer). J Ginseng Res 2005;29:1-18.   과학기술학회마을   DOI   ScienceOn
15 Burns A, Gauthier S, Perdomo C. Efficacy and safety of donepezil over 3 years: an open-label, multicentre study in patients with Alzheimer's disease. Int J Geriatr Psychiatry 2007;22:806-812.   DOI   ScienceOn
16 Courtney C, Farrell D, Gray R, Hills R, Lynch L, Sellwood E, Edwards S, Hardyman W, Raftery J, Crome P et al. Long-term donepezil treatment in 565 patients with Alzheimer's disease (AD2000): randomised double-blind trial. Lancet 2004;363:2105-2115.   DOI   ScienceOn
17 Kanaya K, Abe S, Sakai M, Fujii H, Iwamoto T. Changes in cognitive functions of patients with dementia of the Alzheimer type following long-term administration of donepezil hydrochloride: relating to changes attributable to differences in apolipoprotein E phenotype. Geriatr Gerontol Int 2010;10:25-31.   DOI   ScienceOn