Therapeutic Effect of Total Ginseng Saponin on Skin Wound Healing
![]() |
Kim, Young-Soo
(Department of Veterinary Surgery, Chonnam National University College of Veterinary Medicine)
Cho, Ik-Hyun (Department of Anatomy, College of Oriental Medicine and Institute of Oriental Medicine, Kyung Hee University) Jeong, Moon-Jin (Department of Oral Histology and Developmental Biology, Chosun University School of Dentistry) Jeong, Soon-Jeong (Department of Oral Histology and Developmental Biology, Chosun University School of Dentistry) Nah, Seung-Yeol (Department of Physiology, Konkuk University College of Veterinary Medicine) Cho, Young-Sik (Department of Dental Hygiene, Namseoul University) Kim, Seung-Hyun (Department of Veterinary Surgery, Chonnam National University College of Veterinary Medicine) Go, A-Ra (Department of Veterinary Surgery, Chonnam National University College of Veterinary Medicine) Kim, Se-Eun (Department of Veterinary Surgery, Chonnam National University College of Veterinary Medicine) Kang, Seong-Soo (Department of Veterinary Surgery, Chonnam National University College of Veterinary Medicine) Moon, Chang-Jong (Department of Veterinary Surgery, Chonnam National University College of Veterinary Medicine) Kim, Jong-Choon (Department of Veterinary Surgery, Chonnam National University College of Veterinary Medicine) Kim, Sung-Ho (Department of Veterinary Surgery, Chonnam National University College of Veterinary Medicine) Bae, Chun-Sik (Department of Veterinary Surgery, Chonnam National University College of Veterinary Medicine) |
1 | Toriseva M, Kahari VM. Proteinases in cutaneous wound healing. Cell Mol Life Sci 2009;66:203-224. DOI |
2 | Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med 1999;341:738-746. DOI ScienceOn |
3 | Eming SA, Krieg T, Davidson JM. Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol 2007;127:514-525. DOI ScienceOn |
4 | Hinz B, Mastrangelo D, Iselin CE, Chaponnier C, Gabbiani G. Mechanical tension controls granulation tissue contractile activity and myofibroblast differentiation. Am J Pathol 2001;159:1009-1020. DOI ScienceOn |
5 | Hinz B. Formation and function of the myofibroblast during tissue repair. J Invest Dermatol 2007;127:526-537. DOI ScienceOn |
6 | Kang JS. Cosmetic surgery. 3rd ed. Seoul: Kunga Press, 2004. |
7 | Hsu S. Green tea and the skin. J Am Acad Dermatol 2005;52:1049-1059. DOI ScienceOn |
8 | Rice-Evans CA, Miller NJ, Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med 1996;20:933-956. DOI ScienceOn |
9 | Packer L, Rimbach G, Virgili F. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 1999;27:704-724. DOI ScienceOn |
10 | Babior BM. Phagocytes and oxidative stress. Am J Med 2000;109:33-44. DOI ScienceOn |
11 | Sen CK, Khanna S, Gordillo G, Bagchi D, Bagchi M, Roy S. Oxygen, oxidants, and antioxidants in wound healing: an emerging paradigm. Ann N Y Acad Sci 2002;957:239- 249. DOI ScienceOn |
12 | Sparg SG, Light ME, van Staden J. Biological activities and distribution of plant saponins. J Ethnopharmacol 2004;94:219-243. DOI ScienceOn |
13 | Konishi M, Hano Y, Takayama M, Nomura T, Hamzah AS, Ahmad RB, Jamani H. Triterpenoid saponins from Hedyotis nudicaulis. Phytochemistry 1998;48:525-528. DOI ScienceOn |
14 | Simoes CM, Amoros M, Girre L. Mechanism of antiviral activity of triterpenoid saponins. Phytother Res 1999; 13:323-328. DOI ScienceOn |
15 | Apers S, Baronikova S, Sindambiwe JB, Witvrouw M, De Clercq E, Vanden Berghe D, Van Marck E, Vlietinck A, Pieters L. Antiviral, haemolytic and molluscicidal activities of triterpenoid saponins from Maesa lanceolata: establishment of structure-activity relationships. Planta Med 2001;67:528-532. DOI ScienceOn |
16 | Yogeeswari P, Sriram D. Betulinic acid and its derivatives: a review on their biological properties. Curr Med Chem 2005;12:657-666. DOI |
17 | Just MJ, Recio MC, Giner RM, Cuellar MJ, Máñez S, Bilia AR, Ríos JL. Anti-inflammatory activity of unusual lupane saponins from Bupleurum fruticescens. Planta Med 1998;64:404-407. DOI ScienceOn |
18 | Navarro P, Giner RM, Recio MC, Manez S, Cerda- Nicolas M, Ríos JL. In vivo anti-inflammatory activity of saponins from Bupleurum rotundifolium. Life Sci 2001;68:1199-1206. DOI ScienceOn |
19 | Kimura Y, Sumiyoshi M, Kawahira K, Sakanaka M. Effects of ginseng saponins isolated from red ginseng roots on burn wound healing in mice. Br J Pharmacol 2006;148:860-870. |
20 | Wang ZY, Zhang J, Lu SL. Objective evaluation of burn and post-surgical scars and the accuracy of subjective scar type judgment. Chin Med J (Engl) 2008;121:2517-2520. |
21 | Werner S, Krieg T, Smola H. Keratinocyte-fibroblast interactions in wound healing. J Invest Dermatol 2007; 127:998-1008. DOI ScienceOn |
22 | Guan DW, Ohshima T, Kondo T. Immunohistochemical study on Fas and Fas ligand in skin wound healing. Histochem J 2000;32:85-91. DOI ScienceOn |
23 | Clark RA. Wound repair: overview and general considerations. In: Clark RA, Henson PM. The molecular and cellular biology of wound repair. 2nd ed. New York: Plenum Press, 1996. p.513-560. |
24 | Stephens P, Thomas DW. The cellular proliferative phase of the wound repair process. J Wound Care 2002;11:253- 261. DOI |
25 | Blazso G, Gabor M, Schonlau F, Rohdewald P. Pycnogenol accelerates wound healing and reduces scar formation. Phytother Res 2004;18:579-581. DOI ScienceOn |
26 | Guclu-Ustundag O, Mazza G. Saponins: properties, applications and processing. Crit Rev Food Sci Nutr 2007;47:231-258. DOI ScienceOn |
27 | Baumann E, Stoya G, Volkner A, Richter W, Lemke C, Linss W. Hemolysis of human erythrocytes with saponin affects the membrane structure. Acta Histochem 2000;102:21-35. DOI ScienceOn |
28 | Ramzy PI, Barret JP, Herndon DN. Thermal injury. Crit Care Clin 1999;15:333-352, ix. DOI |
29 | Oda K, Matsuda H, Murakami T, Katayama S, Ohgitani T, Yoshikawa M. Adjuvant and haemolytic activities of 47 saponins derived from medicinal and food plants. Biol Chem 2000;38:67-74. |
30 | Killeen GF, Madigan CA, Connolly CR, Walsh GA, Clark C, Hynes MJ, Timmins BF, James P, Headon DR, Power RF. Antimicrobial saponins of Yucca schidigera and the implications of their in vitro properties for their in vivo impact. J Agric Food Chem 1998;46:3178-3186. DOI ScienceOn |
31 | Lee J, Jung E, Lee J, Huh S, Kim J, Park M, So J, Ham Y, Jung K, Hyun CG et al. Panax ginseng induces human type I collagen synthesis through activation of Smad signaling. J Ethnopharmacol 2007;109:29-34. DOI ScienceOn |
32 |
Choi S. Epidermis proliferative effect of the Panax ginseng ginsenoside |
33 | Kim YG, Sumiyoshi M, Sakanaka M, Kimura Y. Effects of ginseng saponins isolated from red ginseng on ultraviolet B-induced skin aging in hairless mice. Eur J Pharmacol 2009;602:148-156. DOI ScienceOn |
![]() |