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http://dx.doi.org/10.5142/jgr.2011.35.3.360

Therapeutic Effect of Total Ginseng Saponin on Skin Wound Healing  

Kim, Young-Soo (Department of Veterinary Surgery, Chonnam National University College of Veterinary Medicine)
Cho, Ik-Hyun (Department of Anatomy, College of Oriental Medicine and Institute of Oriental Medicine, Kyung Hee University)
Jeong, Moon-Jin (Department of Oral Histology and Developmental Biology, Chosun University School of Dentistry)
Jeong, Soon-Jeong (Department of Oral Histology and Developmental Biology, Chosun University School of Dentistry)
Nah, Seung-Yeol (Department of Physiology, Konkuk University College of Veterinary Medicine)
Cho, Young-Sik (Department of Dental Hygiene, Namseoul University)
Kim, Seung-Hyun (Department of Veterinary Surgery, Chonnam National University College of Veterinary Medicine)
Go, A-Ra (Department of Veterinary Surgery, Chonnam National University College of Veterinary Medicine)
Kim, Se-Eun (Department of Veterinary Surgery, Chonnam National University College of Veterinary Medicine)
Kang, Seong-Soo (Department of Veterinary Surgery, Chonnam National University College of Veterinary Medicine)
Moon, Chang-Jong (Department of Veterinary Surgery, Chonnam National University College of Veterinary Medicine)
Kim, Jong-Choon (Department of Veterinary Surgery, Chonnam National University College of Veterinary Medicine)
Kim, Sung-Ho (Department of Veterinary Surgery, Chonnam National University College of Veterinary Medicine)
Bae, Chun-Sik (Department of Veterinary Surgery, Chonnam National University College of Veterinary Medicine)
Publication Information
Journal of Ginseng Research / v.35, no.3, 2011 , pp. 360-367 More about this Journal
Abstract
In this study, we investigated the effects of total ginseng saponin (TGS) on the cutaneous wound healing process using histological analysis. A total of 24 ICR mice, 5-weeks-old, were used for all in vivo experiments. Mice were divided into control and TGS-treated groups and four equidistant 1-cm full-thickness dorsal incisional wounds were created. The wounds were extracted at days 1, 3, 5, and 7 post-injury for histomorphometrical analysis including wound area and contracture measurements, keratinocyte migration rate, and calculation of infiltrating inflammatory cells. The results showed that the wound area was smaller and keratinocyte migration rate was higher in the TGS-treated group than that of the control group from days 3 to 7. Inflammatory cells in the TGS-treated group at days 1 and 3 were reduced compared to the control group. Wound contraction in the TGS-treated group was greater than in the control group on days 3 to 5, and collagen deposition in the TGS-treated group was higher than in the control group during wound healing. The results indicate a beneficial effect of TGS when used to treat skin wounds.
Keywords
Panax ginseng; Skin wound healing; Total ginseng saponin; Mice;
Citations & Related Records
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Times Cited By Web Of Science : 0  (Related Records In Web of Science)
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