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http://dx.doi.org/10.5142/jgr.2010.34.4.288

Bioconversion of Ginsenoside Rd into Compound K by Lactobacillus pentosus DC101 Isolated from Kimchi  

Quan, Lin-Hu (Korean Ginseng Center for Most Valuable Product and Ginseng Genetic Resource Bank, Kyung Hee University)
Cheng, Le-Qin (Korean Ginseng Center for Most Valuable Product and Ginseng Genetic Resource Bank, Kyung Hee University)
Kim, Ho-Bin (Korean Ginseng Center for Most Valuable Product and Ginseng Genetic Resource Bank, Kyung Hee University)
Kim, Ju-Han (Korean Ginseng Center for Most Valuable Product and Ginseng Genetic Resource Bank, Kyung Hee University)
Son, Na-Ri (Korean Ginseng Center for Most Valuable Product and Ginseng Genetic Resource Bank, Kyung Hee University)
Kim, Se-Young (Korean Ginseng Center for Most Valuable Product and Ginseng Genetic Resource Bank, Kyung Hee University)
Jin, Hyun-O (Korean Ginseng Center for Most Valuable Product and Ginseng Genetic Resource Bank, Kyung Hee University)
Yang, Deok-Chun (Korean Ginseng Center for Most Valuable Product and Ginseng Genetic Resource Bank, Kyung Hee University)
Publication Information
Journal of Ginseng Research / v.34, no.4, 2010 , pp. 288-295 More about this Journal
Abstract
Ginsenosides are the principal components responsible for the pharmacological and biological activities of ginseng. Ginsenoside Rd was transformed into compound K using cell-free extracts of food microorganisms, with Lactobacillus pentosus DC101 isolated from kimchi (traditional Korean fermented food) used for this conversion. The optimum time for the conversion was about 72 h at a constant pH of 7.0 and an optimum temperature of about $30^{\circ}C$. The transformation products were identified by thin-layer chromatography and high-performance liquid chromatography, and their structures were assigned using nuclear magnetic resonance analysis. Generally, ginsenoside Rd was converted into ginsenoside F2 by 36 h post-reaction. Consequently, over 97% of ginsenoside Rd was decomposed and converted into compound K by 72 h post-reaction. The bioconversion pathway to produce compound K is as follows: ginsenoside Rd$\rightarrow$ginsenoside F2$\rightarrow$compound K.
Keywords
Bioconversion; Compound K; Ginsenoside modification; Kimchi; Lactobacillus pentosus DC101;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 4  (Related Records In Web of Science)
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