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http://dx.doi.org/10.5142/jgr.2010.34.3.155

Merit of Ginseng in the Improvement of Insulin Resistance  

Cheng, Juei-Tang (Department of Medical Research, Chi-Mei Medical Center and Institute of Medical Science, Chang Jung Christian University)
Publication Information
Journal of Ginseng Research / v.34, no.3, 2010 , pp. 155-159 More about this Journal
Abstract
In the present review, the merit of ginseng in the improvement of insulin resistance has been introduced. Using the results in previous studies, we found that ginseng or ginsenoside Rh2 has the ability to reduce glucose-insulin index in rats with insulin resistance. Insulin resistance was induced by feeding of fructose-rich chow in rats. Insulin resistance was characterized by regular methods. Effectiveness of ginseng powder or extract Rh2 was identified in this animal model. Also, the application of ginseng for handling of diabetic disorders in China has been discussed. According to Chinese traditional medicine, ginseng is merit in the treatment of diabetic disorders named as Shiaw-Ker in Chinese. Therefore, it is no doubt that ginseng is helpful in the control of diabetic disorders either prevention or the treatment. Otherwise, the potential effect of ginseng on nervous functions shall be investigated in the future.
Keywords
Ginsenoside Rh2; Insulin resistance; Panax ginseng; Rats; Shiaw-Ker;
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1 Lee KS, Yu WJ, Wang MJ, Wu HT, Chang CH, Cheng JT. Autonomic regulation of insulin secretion is changed by pentobarbital in mice. Neurosci Lett 2010;479:6-9.   DOI   ScienceOn
2 Fisher A, Michaelson DM, Brandeis R, Haring R, Chapman S, Pittel Z. M1 muscarinic agonists as potential disease-modifying agents in Alzheimer’s disease: rationale and perspectives. Ann N Y Acad Sci 2000;920:315-320.   DOI
3 Attele AS, Zhou YP, Xie JT, Wu JA, Zhang L, Dey L, Pugh W, Rue PA, Polonsky KS, Yuan CS. Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes 2002;51:1851-1858.   DOI
4 Wang L, Higashiura K, Ura N, Miura T, Shimamoto K. Chinese medicine, Jiang-Tang-Ke-Li, improves insulin resistance by modulating muscle fiber composition and muscle tumor necrosis factor-alpha in fructose-fed rats. Hypertens Res 2003;26:527-532.   DOI   ScienceOn
5 Xie JT, Mehendale SR, Wang A, Han AH, Wu JA, Osinski J, Yuan CS. American ginseng leaf: ginsenoside analysis and hypoglycemic activity. Pharmacol Res 2004;49:113-117.   DOI   ScienceOn
6 Cheng JT. Herbs used to treat diabetes mellitus in Chinese traditional medicine. In: Majumdar DK, Govil JN, Singh VK, editors. Recent progress in medicinal plants. Vol. 8, Phytochemistry & pharmacology II. Houston: Sci Tech Publishing, 2003. p.175-184.
7 Lee WK, Kao ST, Liu IM, Cheng JT. Ginsenoside Rh2 is one of the active principles of Panax ginseng root to improve insulin sensitivity in fructose-rich chow-fed rats. Horm Metab Res 2007;39:347-354.   DOI   ScienceOn
8 Shieh PC, Tsao CW, Li JS, Wu HT, Wen YJ, Kou DH, Cheng JT. Role of pituitary adenylate cyclase-activating polypeptide (PACAP) in the action of ginsenoside Rh2 against beta-amyloid-induced inhibition of rat brain astrocytes. Neurosci Lett 2008;434:1-5.   DOI   ScienceOn
9 Park MY, Lee KS, Sung MK. Effects of dietary mulberry, Korean red ginseng, and banaba on glucose homeostasis in relation to PPAR-alpha, PPAR-gamma, and LPL RNA expressions. Life Sci 2005;77:3344-3354.   DOI   ScienceOn
10 Niu CS, Yeh CH, Yeh MF, Cheng JT. Increase of adipogenesis by ginsenoside (Rh2) in 3T3-L1 cell via an activation of glucocorticoid receptor. Horm Metab Res 2009; 41:271-276.   DOI   ScienceOn
11 Su CF, Chang YY, Pai HH, Liu IM, Lo CY, Cheng JT. Infusion of beta-endorphin improves insulin resistance in fructose-fed rats. Horm Metab Res 2004;36:571-577.   DOI   ScienceOn
12 Lai DM, Tu YK, Liu IM, Chen PF, Cheng JT. Mediation of beta-endorphin by ginsenoside Rh2 to lower plasma glucose in streptozotocin-induced diabetic rats. Planta Med 2006;72:9-13.   DOI   ScienceOn
13 Attele AS, Wu JA, Yuan CS. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol 1999;58:1685-1693.   DOI   ScienceOn
14 Lee KY, Park JA, Chung E, Lee YH, Kim SI, Lee SK. Ginsenoside-Rh2 blocks the cell cycle of SK-HEP-1 cells at the G1/S boundary by selectively inducing the protein expression of p27kip1. Cancer Lett 1996;110:193-200.   DOI   ScienceOn
15 Park EK, Choo MK, Kim EJ, Han MJ, Kim DH. Antiallergic activity of ginsenoside Rh2. Biol Pharm Bull 2003;26:1581-1584.   DOI   ScienceOn
16 Lee WK, Kao ST, Liu IM, Cheng JT. Increase of insulin secretion by ginsenoside Rh2 to lower plasma glucose in Wistar rats. Clin Exp Pharmacol Physiol 2006;33:27-32.   DOI   ScienceOn
17 Le KA, Tappy L. Metabolic effects of fructose. Curr Opin Clin Nutr Metab Care 2006;9:469-475.   DOI   ScienceOn
18 Henriksen EJ, Jacob S, Kinnick TR, Teachey MK, Krekler M. Selective angiotensin II receptor receptor antagonism reduces insulin resistance in obese Zucker rats. Hypertension 2001;38:884-890.   DOI   ScienceOn
19 Chang JC, Wu MC, Liu IM, Cheng JT. Increase of insulin sensitivity by stevioside in fructose-rich chow-fed rats. Horm Metab Res 2005;37:610-616.   DOI   ScienceOn
20 Foianini KR, Steen MS, Kinnick TR, Schmit MB, Youngblood EB, Henriksen EJ. Effects of exercise training and ACE inhibition on insulin action in rat skeletal muscle. J Appl Physiol 2000;89:687-694.   DOI
21 Kahn CR. Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes. Diabetes 1994;43:1066-1084.   DOI
22 Liu TP, Liu IM, Cheng JT. Improvement of insulin resistance by panax ginseng in fructose-rich chow-fed rats. Horm Metab Res 2005;37:146-151.   DOI
23 Kruszynska YT, Olefsky JM. Cellular and molecular mechanisms of non-insulin dependent diabetes mellitus. J Investig Med 1996;44:413-428.
24 Henriksen EJ. Invited review: effects of acute exercise and exercise training on insulin resistance. J Appl Physiol 2002;93:788-796.   DOI
25 Kennedy DO, Scholey AB. Ginseng: potential for the enhancement of cognitive performance and mood. Pharmacol Biochem Behav 2003;75:687-700.   DOI   ScienceOn
26 Block KI, Mead MN. Immune system effects of echinacea, ginseng, and astragalus: a review. Integr Cancer Ther 2003;2:247-267.   DOI
27 Kimura M, Suzuki J. The pattern of action of blended Chinese traditional medicines to glucose tolerance curves in genetically diabetic KK-CAy mice. J Pharmacobiodyn 1981;4:907-915.   DOI
28 Van Kampen J, Robertson H, Hagg T, Drobitch R. Neuroprotective actions of the ginseng extract G115 in two rodent models of Parkinson’s disease. Exp Neurol 2003;184:521-529.   DOI   ScienceOn
29 Kiefer D, Pantuso T. Panax ginseng. Am Fam Physician 2003;68:1539-1542.
30 Kimura M, Waki I, Tanaka O, Nagai Y, Shibata S. Pharmacological sequential trials for the fractionation of components with hypoglycemic activity in alloxan diabetic mice from ginseng radix. J Pharmacobiodyn 1981;4:402-409.   DOI
31 Yokozawa T, Kobayashi T, Oura H, Kawashima Y. Studies on the mechanism of the hypoglycemic activity of ginsenoside-Rb2 in streptozotocin-diabetic rats. Chem Pharm Bull (Tokyo) 1985;33:869-872.   DOI   ScienceOn
32 Kahn SE. Clinical review 135: the importance of beta-cell failure in the development and progression of type 2 diabetes. J Clin Endocrinol Metab 2001;86:4047-4058.   DOI