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http://dx.doi.org/10.5142/jgr.2010.34.2.104

Effects of Fermented Red Ginseng Extracts on Hyperglycemia in Streptozotocin-induced Diabetic Rats  

Kim, Hyun-Jeong (The Center for Traditional Microorganism Resources, Keimyung University)
Chae, In-Gyeong (Department of Food and Technology, Keimyung University)
Lee, Sung-Gyu (Department of Food and Technology, Keimyung University)
Jeong, Hyun-Jin (Bio Research Institute, NUC Electronics Co. Ltd.)
Lee, Eun-Ju (Bio Research Institute, NUC Electronics Co. Ltd.)
Lee, In-Seon (The Center for Traditional Microorganism Resources, Keimyung University)
Publication Information
Journal of Ginseng Research / v.34, no.2, 2010 , pp. 104-112 More about this Journal
Abstract
Fermented red ginseng (FRG) was prepared by inoculating 0.1% Lactobacillus fermentum NUC-C1 and fermenting them at $40^{\circ}C$ for 12 hours. The ginsenoside contents of FRG were increased compared with those of red ginseng (RG). Moreover, the levels of the ginsenosides Rg2, Rg3, and Rh2 in FRG increased significantly. In an oral glucose tolerance test (OGTT), blood glucose levels were lower in animals fed with RG and FRG extracts than in normal controls. In particular, FRG extracts in OGTT were superior to RG extracts. The antidiabetic effects of FRG in streptozotocin (STZ)-induced diabetic rats were investigated. Rats were divided into four groups: normal control, diabetes mellitus (DM), FRG administered at 100 mg/kg, and FRG administered at 200 mg/kg groups. FRG extracts were orally administered to each treatment group for 3 weeks, and blood glucose, insulin, and lipid levels of each group were determined. Orally administered FRG extracts significantly reduced blood glucose levels and increased plasma insulin levels in diabetic rats. Additionally, the activities of disaccharidases, including sucrase, lactase, and maltase, were decreased significantly in the FRG groups. FRG groups also had reduced triglyceride and total cholesterol levels, compared with the DM group. These results suggest that FRG may have antidiabetic effects in STZ-induced diabetic rats.
Keywords
Red ginseng; Fermentation; Antidiabetic effect; Streptozotocin;
Citations & Related Records
Times Cited By KSCI : 15  (Citation Analysis)
Times Cited By Web Of Science : 4  (Related Records In Web of Science)
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1 Lee IS, Lee S, Lee IZ. Effects of tissue cultured ginseng on blood glucose and lipids in streptozotocin-induced diabetic rats. Korean J Food Sci Technol 2003;35:280-285.   과학기술학회마을
2 O’Meara NM, Devery RA, Owens D, Collins PB, Johnson AH, Tomkin GH. Cholesterol metabolism in alloxan-induced diabetic rabbits. Diabetes 1990;39:626-633.   DOI   ScienceOn
3 Kim HS, Seong YH, Yang JW, Jeon BS, Park UY, Park WK, Oh KW, Choi KJ. Hypoglycemic effects of extract mixture of red ginseng and steamed RehManiae Radix on streptozotocin-induced diabetic rats. Korean J Ginseng Sci 1997;21:169-173.   과학기술학회마을
4 Adachi T, Mori C, Sakurai K, Shihara N, Tsuda K, Yasuda K. Morphological changes and increased sucrase and isomaltase activity in small intestines of insulin-deficient and type 2 diabetic rats. Endocr J 2003;50:271-279.   DOI   ScienceOn
5 Yao HT, Huang SY, Chiang MT. A comparative study on hypoglycemic and hypocholesterolemic effects of high and low molecular weight chitosan in streptozotocin-induced diabetic rats. Food Chem Toxicol 2008;46:1525-1534.   DOI   ScienceOn
6 Kim SH, Kang JS, Lee SJ, Chung YJ. Antidiabetic effect of Korean red ginseng by puffing process in streptozotocin-induced diabetic rats. J Korean Soc Food Sci Nutr 2008;37:701-707.   DOI   ScienceOn
7 Kim MW. Effects of Salicornia herbacea L. supplementation on blood glucose and lipid metabolites in streptozotocin-induced diabetic rats. Korean J Nutr 2007;40:5-13.   과학기술학회마을
8 Bae EA, Park SY, Kim DH. Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol Pharm Bull 2000;23:1481-1485.   DOI   ScienceOn
9 Sathishsekar D, Subramanian S. Beneficial effects of Momordica charantia seeds in the treatment of STZ-induced diabetes in experimental rats. Biol Pharm Bull 2005;28:978-983.   DOI   ScienceOn
10 Liu Z, Li J, Zeng Z, Liu M, Wang M. The antidiabetic effects of cysteinyl metformin, a newly synthesized agent, in alloxan- and streptozotocin-indued diabetic rats. Chemico-Biological Interactions 2008;173:68-75.   DOI   ScienceOn
11 Lai DM, Tu YK, Liu IM, Chen PF, Cheng JT. Mediation of beta-endorphin by ginsenoside Rh2 to lower plasma glucose in streptozotocin-induced diabetic rats. Planta Med 2006;72:9-13.   DOI   ScienceOn
12 Dahlqvist A. Assay of intestinal disaccharidases. Anal Biochem 1968;22:99-107.   DOI   ScienceOn
13 Quan LH, Liang Z, Kim HB, Kim SH, Kim SY, Noh YD, Yang DC. Conversion of ginsenoside Rd to compound K by crude enzymes extracted from Lactobacillus brevis LH8. J Ginseng Res 2008;32:226-231.   DOI   ScienceOn
14 Suda K, Murakami K, Murata Jun, Hasegawa H, Saiki IL. An intestinal bacterial metabolite (M1) of ginseng protopanaxadiol saponins inhibits tumor-induced neovascularization. J Tradit Med 2000;17:144-150.
15 Kim DH. Metabolism of ginsenosides to bioactive compounds by intestinal microflora and its industrial application. J Ginseng Res 2009;33:165-176.   DOI
16 Park HR, Cho JS. Effect of natural medicinal plants-extracts on organ weight and blood glucose challenge in Streptozotocin-induced diabetic rats. J Nat Sci 2006;25: 43-53.
17 Kim EM. Quality characteristics of jeung-pyun according to the level of red ginseng powder. Korean J Food Cookery Sci 2005;21:209-216.   과학기술학회마을
18 Ko SK, Lee CR, Choi YE, Im BO, Sung JH, Yoon KR. Analysis of ginsenosides of white and red ginseng concentrates. Korean J Food Sci Technol 2003;35:536-539.   과학기술학회마을
19 Kim ND. Pharmacological effects of red ginseng. J Ginseng Res 2001;25:2-10.
20 Lee BJ, Heo H, Oh SC, Lew JH. Comparison study of Korean and Chinese ginsengs on the regulation of lymphocyte proliferation and cytokine production. J Ginseng Res 2008;32:250-256.   DOI   ScienceOn
21 Kim US, Koh HK, Kang SK. Study of the effects of different products of ginseng radix aqua-acupuncture on the alloxan-induced diabetic rats. J Korean Acupunct Moxibust Soc 1989;6:1-13.
22 Yun TK, Lee YS, Lee YH, Yun HY. Cancer chemopreventive compounds of red ginseng produced from Panax ginseng C.A. Meyer. J Ginseng Res 2001;25:107-111.   과학기술학회마을
23 Kim DJ, Seong KS, Kim DW, Ko SR, Chang CC. Antioxidative effects of red ginseng saponins of paraquat-induced oxidative stress. J Ginseng Res 2004;28:5-10.   DOI   ScienceOn
24 Lee CK, Choi JW, Kim H, Han YN. Biological activities of acidic polysaccharide of Korean red ginseng. II. Effects on hyperlipidemia induced by alcohol. J Ginseng Res 1999;23:8-12.
25 Bae EA, Han MJ, Kim EJ, Kim DH. Transformation of ginseng saponins to ginsenoside Rh2 by acids and human intestinal bacteria and biological activities of their transformants. Arch Pharm Res 2004;27:61-67.   DOI   ScienceOn
26 Trinh HT, Han SJ, Kim SW, Lee YC, Kim DH. Bifidus fermentation increases hypolipidemic and hypoglycemic effects of red ginseng. J Microbiol Biotechnol 2007;17:1127-1133.
27 Choi MJ. Comparison of dietary casein or soy protein effect on plasma glucose, lipids, and hormone concentrations in the streptozotocin-induced diabetic rats. J Res Inst Life Sci 1997;23:285-295.
28 Lim SJ, Han HK, Ko JH. Effects of edible and medicinal plants intake on blood glucose, glycogen and protein levels in streptozotocin induced diabetic rats. Korean J Nutr 2003;36:981-989.   과학기술학회마을
29 Park KS, Ko SK, Chung SH. Comparisons of antidiabetic effect between Ginseng Radix Alba, Ginseng Radix Rubra and Panax Quinquefoli Radix in MLD STZ-induced diabetic rats. J Ginseng Res 2003;27:56-61.   DOI   ScienceOn
30 Kim HS, Seong YH, Yang JW, Jeon BS, Park UY, Park WK, Oh KW, Choi KJ. Hypoglycemic effects of extract mixture of red ginseng and steamed RehManiae radix on streptozotocin-induced diabetic rats. Korean J Ginseng Sci 1997;21:169-173.   과학기술학회마을
31 Attele AS, Wu JA, Yuan CS. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol 1999;58:1685-1693.   DOI   ScienceOn
32 Yoon SH, Joo CN. Study on the preventive effect of ginsenosides against hypercholesterolemia and its mechasnism. Korean J Ginseng Sci 1993;17:1-12.   과학기술학회마을
33 Woo KS, Kim CM, Koo KH. An experimental study on the effect of ginseng saponin upon diabetes mellitus. Hanyang J Med 1982;2:47-57.
34 Lim SJ, Kim SY, Lee JW. The effects of Korean wild vegetables on blood glucose levels and liver-muscle metabolism of stretozotocin-induced diabetic rats. Korean J Nutr 1995;28:585-594.   과학기술학회마을
35 Rho MH, Choi MA, Koh JB. Effects of raw soy flour (yellow and black) on serum protein concentrations and enzyme activity in streptozotocin-diabetic rats. J Korean Soc Food Sci Nutr 1998;27:724-730.
36 Choi JS, Chung HY, Han SY. A preliminary study on hypercholesterolemic and hyperglycemic activities of some medical plants. Korean J Pharm 1990;21:153-157.
37 George P, Ludvik B. Lipids and diabetes. J Clin Basic Cardiol 2000;3:159-162.
38 Park YM, Sohn CM, Jang HC. A study on status and subjective recognition of functional foods among diabetic patients. J Korean Diet Assoc 2005;11:216-222.
39 Korea National Statistical Office. The cause of death statistics 2008: 2009 annual report on the cause of death statics. [accessed Mar 15, 2010]. Available from: http://kostat.go.kr/board_notice/BoardAction.do?method=view&board_id=144&seq=85&num=85&parent_num=0.
40 Kim TH, Yang KS, Whang SH. Studies on the physiochemical activities of Commelinae herba extract on the normal and streptozotocin-induced hyperglycemic rats. SM Pharm Sci 1990;7:39-59.