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http://dx.doi.org/10.5142/JGR.2009.33.4.305

Enhanced Protective Effect of Ultrafine Particles of Red-Ginseng against Phenanthrene-induced Cell Damage  

Seo, Yoo-Na (Department of Medical Biotechnology, SoonChunHyang University)
Lee, Mi-Young (Department of Medical Biotechnology, SoonChunHyang University)
Publication Information
Journal of Ginseng Research / v.33, no.4, 2009 , pp. 305-310 More about this Journal
Abstract
Phenanthrene, one of the polycyclic aromatic hydrocarbons, has been known to be toxic to the environment. In this investigation, the protective effect of red ginseng on phenanthrene-induced oxidative DNA damage was evaluated using Comet assay in A549 cells. Red ginseng's cytoprotective effect on phenanthrene-induced hemolysis was also investigated. This study's findings show that oxidative DNA damage and hemolysis were significantly prevented by red ginseng treatment. Notably, it was found that pulverizing red ginseng into ultra-fine particles even enhanced its protective effects against DNA damage and hemolysis. The results suggest that particle size reduction seems to effectively enhance red ginseng's pharmacological efficacies.
Keywords
red ginseng; particle size reduction; cytoprotection; phenanthrene;
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