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http://dx.doi.org/10.5142/JGR.2007.31.4.175

Effect of Korean Red Ginseng on Serum Soluble CD8 in HIV-1-Infected Patients  

Cho, Young-Keol (Department of Microbiology, University of Ulsan College of Medicine)
Sung, Heung-Sup (Department of Microbiology, University of Ulsan College of Medicine)
Publication Information
Journal of Ginseng Research / v.31, no.4, 2007 , pp. 175-180 More about this Journal
Abstract
To evaluate whether there is a relation between Korean red ginseng (KRG)-intake and the suppression of immune hyperactivation in HIV-1-infected patients, we measured serum soluble CD8 (sCD8) over 31-48 months in 168 patients. They were divided into four groups; HIV-1-infected control (n = 49), zidovudine (ZDV) group (n = 22), KRG group (n = 48), and combination of KRG and ZDV group (n = 49). In control, sCD8 and the ratio of sCD8/CD8+ T cells significantly increased by 33% (paired t-test, P < 0.05) and 54% over $21\;{\pm}\;13$ months (P < 0.001), respectively. In ZDV group, sCD8 decreased within first 6 months and then showed steady increase and the ratio also increased over $19\;{\pm}\;10$ months. In KRG group, sCD8 and the ratio of sCD/CD8+ T cells continuously decreased by 45% (P < 0.01) and 19% over $19\;{\pm}\;11$ months (P < 0.05), respectively. In combination group, sCD8 gradually decreased by 29% (P < 0.01). There was a clear difference in the changes in serum sCD8 over time among 4 groups. There was no rebound phenomenon in KRG group as shown in ZDV group. These results suggest that KRG-intake suppresses immune hyperactivation state by HIV antigen itself in the HIV-infected patients.
Keywords
HIV-1 infection; soluble CD8 antigen; Korean red ginseng; zidovudine;
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