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http://dx.doi.org/10.5142/JGR.2007.31.2.079

Effects of Compound K on Insulin Secretion and Carbohydrate Metabolism  

Choi, Yun-Suk (Pharmacology and Clinical Pharmacy Lab, College of Pharmacy, Kyung Hee University)
Han, Gi-Cheol (Pharmacology and Clinical Pharmacy Lab, College of Pharmacy, Kyung Hee University)
Han, Eun-Jung (Pharmacology and Clinical Pharmacy Lab, College of Pharmacy, Kyung Hee University)
Park, Kum-Ju (Pharmacology and Clinical Pharmacy Lab, College of Pharmacy, Kyung Hee University)
Sung, Jong-Hwan (ILHWA Co. LTD. Central Research Center)
Chung, Sung-Hyun (Pharmacology and Clinical Pharmacy Lab, College of Pharmacy, Kyung Hee University)
Publication Information
Journal of Ginseng Research / v.31, no.2, 2007 , pp. 79-85 More about this Journal
Abstract
Compound K (CK) is a final metabolite of panaxadiol ginsenosides. Although panax ginseng is known to have anti-diabetic activity, the active ingredient is not yet fully identified. Therefore, it would be interesting to know whether and how CK has an anti-diabetic activity. First, insulin secretion-stimulating activity of CK was examined using RIN-m5F cell line and primary cultured islets. CK enhanced the insulin secretion in a concentration dependent manner. This effect, however, was almost completely abolished in the presence of diazoxide, $K^+$ channel opener, indicating that the insulin secretion-stimulating activity of CK is presumably due to blockade of ATP sensitive $K^+$ channel. In addition, effects of CK on gene expressions of hepatic enzymes (phosphoenolpyruvate carboxykinase[PEPCK], glucose-6-phos-phatase[G6Pase]) and on adipocyte differentiation in H4IIE and 3T3-Ll cells, respectively, were examined. CK suppressed the induction of PEPCK and G6Pase mRNA expressions under the dexamethasone/cAMP stimulation condition. CK also reduced the $PPAR-{\gamma}$ mRNA expression and triglyceride accumulation in a dose dependent manner as compared to the control. The present study suggests that CK deserves to examine whether it shows an anti-diabetic activity in animal and human studies.
Keywords
compound K; anti-diabetic activity; insulin secretion; ATP sensitive $K^+$ channel; PEPCK; G6Pase; $PPAR-{\gamma}$;
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