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http://dx.doi.org/10.5142/JGR.2007.31.2.074

Effects of Non-Saponin Red Ginseng Components on Multi-drug Resistance  

Kim, Eun-Hye (College of Pharmacy, SungKyunKwan University)
Park, Jong-Dae (Ginseng Science Research Group, KT & G Central Research Institute)
Pyo, Suhk-Neung (College of Pharmacy, SungKyunKwan University)
Rhee, Dong-Kwon (College of Pharmacy, SungKyunKwan University)
Publication Information
Journal of Ginseng Research / v.31, no.2, 2007 , pp. 74-78 More about this Journal
Abstract
Multi-drug resistance (MDR) is a major problem in cancer chemotherapy and has often ended up with termination of the therapy. The aim of this study was to identify any fractions of Korean red ginseng that would be effective in modulating for MDR. Although ginsenosides have been reviewed as possible MDR modulators, the MDR modulation activity of the other component is unknown. Therefore, a red ginseng was extracted with methanol, ether, ethylacetate, and n-butanol, followed by several fractionations by silica gel chromatography. And the activity of MDR modulating for these fractions was examined via sulforrhodamine B assay. We have found that several ether fractions, as nonsaponin components are effective on MDR modulation. We have expect that these results helpful to improvement of cancer chemotherapy.
Keywords
Red ginseng; multi-drug resistance; multi-drug related protein; MDR; MRP;
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