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http://dx.doi.org/10.5142/JGR.2006.30.4.194

The Effect of Red Ginseng on Ultraviolet B-induced Skin Damages in Mouse  

Lee, Hae-June (College of Veterinary Medicine, Chonnam National University)
Kim, Se-Ra (College of Veterinary Medicine, Chonnam National University)
Kim, Joong-Sun (College of Veterinary Medicine, Chonnam National University)
Moon, Chang-Jong (College of Veterinary Medicine, Chonnam National University)
Kim, Jong-Choon (College of Veterinary Medicine, Chonnam National University)
Bae, Chun-Sik (College of Veterinary Medicine, Chonnam National University)
Jang, Jong-Sik (Department of Animal Science, Sangju National University)
Jo, Sung-Kee (Advanced Radiation Technology Institute, KAERI)
Kim, Sung-Ho (College of Veterinary Medicine, Chonnam National University)
Publication Information
Journal of Ginseng Research / v.30, no.4, 2006 , pp. 194-198 More about this Journal
Abstract
The effects of red ginseng (RG) on the changes of ultraviolet (UV) light B radiation-induced apoptotic sun-burn cell (SBC) and epidermal ATPase-positive dendritic cell (DC) in SKH 1-hr or ICR mouse were investigated. The mice were treated with UVB ($200mJ/cm^2$) and were sacrificed 24 hours later. RG (50 mg/kg of body weight) or vehicle (saline) was given i.p. at 36 and 12 hours before irradiation, and 30 minutes after irradiation. RG cream (0.2%) or cream base (vehicle) was also topically treated at 24 hours and 15 minutes before irradiation, and immediately after irradiation. The skin of SKH 1-hr mouse prepared from the back of untreated mice exhibited about 0.3 SBC/cm length of epidermis, and 24 hours after UV irradiation, the applied areas show an increased number of SBCs. But the frequency of UVB-induced SBC formation was significantly reduced by intraperitoneal injection of RG extract. The numbers of DC in normal ICR mouse were $628.00{\pm}51.56\;or\;663.20{\pm}62.58\;per\;mm^2$ of ear epidermis. By 1 day after UVB treatment, the number of ATPase-positive $cells/mm^2$ were decreased by 39.0% or 27.1% in i.p. or topical application group with vehicle. The frequency of UVB ($200mJ/cm^2$)-induced DC decrease was reduced by treatment of RG as 31.3% in i.p. group and 22.4% in topical application group compared with the irradiation control group. The results presented herein that RG administration could reduce the extent of skill damages produced by UVB.
Keywords
ultraviolet B; sunburn cell; ATPase-positive dendritic cell; red ginseng;
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