Browse > Article
http://dx.doi.org/10.5142/JGR.2005.29.2.086

Inhibitory Action of the Ginseng Total Saponin on the Nalbuphine-Induced Tolerance and Withdrawal Syndrome  

Kim, Dong-Hyun (Graduate School of Pharmacy, Chungbuk National University)
Yoo, Hwan-Soo (Graduate School of Pharmacy, Chungbuk National University)
Jang, Choon-Gon (College of Pharmacy, Sung Kyun Kwan University)
Kang, Jong-Seok (Graduate School of Sports Science, Korea Natioanl Sports University)
Kim, Dong-Sup (Department of Pharmacology, Korea Food and Drug Administration)
Choi, Ki-Hwan (Department of Pharmacology, Korea Food and Drug Administration)
Jang, So-Yong (Department of Neuroscience, School of Medicine, Ewha University)
Oh, Sei-Kwan (Department of Neuroscience, School of Medicine, Ewha University)
Publication Information
Journal of Ginseng Research / v.29, no.2, 2005 , pp. 86-93 More about this Journal
Abstract
This study was undertaken to determine the antagonism of the ginseng total saponin (GTS) on the development of nalbuphine-induced tolerance and physical dependence. GTS is blown to have antinarcotic action with a dose of 100mg/kg (i.p.) in rats. STS significantly inhibits the development of nalbuphine-induced physical dependence as well as the tolerance. The level of pCREB was elevated in the striatum by the chronic treatment with nalbuphine or GTS, how-ever, the elevation of pCREB was inhibited by the GTS co-treatment. It has been suggested that NMDA receptor and/or NO is involved in the penomena of opioid dependence and withdrawal. However, the level of nNOS and NR1 was not modulated by the treatment with nalbuphine or GTS on the cortex, hippocampus and striatum in the rat brain. These results suggest that the GTS could be used to ameliorate the nalbuphine tolerance and withdrawal symptoms.
Keywords
nalbuphine; analgesia; tolerance; dependence; pCREB;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Walker, E.A. and Young, A.M.: Discriminative-stimulus effects of the low efficacy agonist nalbuphine. J. Pharmacol Exp. Ther. 267, 322-330 (1993)
2 Chen, J.C., Smith, E.R., Cahill, M., Cohen, R. and Fishman, J.R.: The opioid receptor binding of pentazocine, morphine, fentanyl, butorphanol and nalbuphine. Life Sci. 52, 389-396 (1992)
3 Schmidt, W.K., Tam, S.W., Shotzberger, G.S., Smith, D.H. Jr, Clark, R. and Vemier, V.G.: Nalbuphine. Drug Alcohol Depend. 14, 339-362 (1985)   DOI   ScienceOn
4 Penning, J.P., Samson, B., Baxter, A.D.: Reversal of epidural morphine-induced respiratory depression and pruritus with nalbuphine. Can. J. Anaesth. 35, 599-604 (1988)   DOI   ScienceOn
5 Cuellar, B., Fernandez, A.P., Lizasoain, l., Moro, M.A., Lorenzo, P., Bentura, M.L., Rodrigo, J. and Leza, J.C.: Upregulation of neuronal NO synthase immunoreactivity in opiate dependence and withdrawal. Psychopharmacology (Berl.) 148, 66-73 (2000)   DOI
6 Koyuncuoglu, H., Dizdar, Y., Aricioglu, F. and Sayin, U.: Efects of MK-801 on morphine physical dependence: attenuation and intensification. Pharmacol. Biochem. Behav. 43, 484-490 (1992)
7 Tokuyama, S., Wakabayashi, H. and Ho, I.K.: Direct evidence for a role of glutamate in the expression of opioid withdrawal syndrome. Eur. J. Pharmacol. 295, 123-129 (1996)   DOI   ScienceOn
8 Noda, Y., Yamada, K., Komori, Y., Sugihara, H., Furukawa, H., Nabeshima, T.: Role of nitric oxide in the development of tolerance and sensitization to behavioral effects of phencyclidine in mice. Br. J. Pharmacol. 204, 339-340 (1996)
9 Kim H. S., Kang, J. G. and Oh, K. W: Inhibition of ginseng total saponin of the development of morphine reverse tolerance and dopamine receptor supersensitivity in mice. Gen. Pharmacol. 26,1071-1076 (1995a)   DOI   ScienceOn
10 Tokuyama, S., Oh, K. W., Kim, H. S., Takahashi, M., and Kaneto, H.: Blockade by ginseng extract of the development of reverse tolerance to the ambulation-accelerating effect of methamphetamine in mice. Jpn. J. Pharmacol. 59, 423-425 (1992)   DOI
11 Kim, H. S., Kang J. G., Seong Y. H., Nam K. Y. and Oh, K. W.: Blockade by ginseng total saponin of the development of cocaine induced reverse tolerance and dopamine receptor supersensitivity in mice. Pharmacol. Biochem. Behav. 50, 23-27 (1995b)   DOI   ScienceOn
12 Nagamatsu, K., Kido, Y., Terao, T., Ishida, T. and Toki, S.: Studies on the mechanism of covalent binding of morphine metabolites to proteins in mouse. Drug Meta. Dispos. 11, 190-194 (1983)
13 Nestler, E.J.: Molecular mechanisms of drug addiction. J. Neurosci. 12, 2439-2450 (1992)
14 D'Amour, F.E. and Smith, D.L.: A method for determining loss of pain sensation. J. Pharmacol. Exp. Ther. 72, 74-79 (1942)
15 Ellman, G.L.: Tissue sulfhydryl compounds on acute toxicity of morphinone. Arch. Biochem. Biophys. 82, 70-77 (1959)   DOI   ScienceOn
16 Nestler, E.J., Hyman, S.E. and Malenka, R.C.: Signalling to the nucleus. pp 115-137. in Molecular neuropharmacology, McGraw-Hill, New York (2001)
17 Kim, D.S., Lim, H.K., lang, S. and Oh, S.: Changes of the level of G protein -subunit mRNA by tolerance to and withdrawal from butorphanol. Neurochem. Res. 28, 1771-1778(2003)   DOI   ScienceOn
18 Nagamatsu, K., Kido, Y., Terao, T., Ishida, T. and Toki, S.: Effect of morphinone on opiate receptor binding and morphine-elicited analgesia. Life Sci. 31, 1451-1457 (1982)   DOI   ScienceOn
19 Nagamatsu, K., Kido, Y., Terao, T., Ishida, T. and Toki, S.: Protective effect of sulfhydryl compounds on acute toxicity of morphinone. Life Sci. 30, 1121-1127 (1982)   DOI   ScienceOn
20 Oh, S., Kim, J.I., Chung, M.W. and Ho, I.K.: Modulation of NMDA receptor subunit mRNA in butorphanol-tolerant and -withdrawing rats. Neurochem. Res. 25: 1603-1611 (2000)   DOI   ScienceOn