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http://dx.doi.org/10.5142/JGR.2004.28.4.173

Korean Red Ginseng Significantly Slows CD4 T Cell Depletion over 10 Years in HIV-1 Infected Patients: Association with HLA  

Cho, Young-Keol (Department of Microbiology, University of Ulsan College of Medicine)
Sung, Heungsup (Department of Microbiology, University of Ulsan College of Medicine)
Kim, Tai Kyu (Department of Microbiology, College of Medicine, The Catholic University of Korea)
Lim, Ji Youn (Department of Microbiology, University of Ulsan College of Medicine)
Jung, You Sun (Department of Microbiology, University of Ulsan College of Medicine)
Kang, Sang-Moo (Department of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine)
Publication Information
Journal of Ginseng Research / v.28, no.4, 2004 , pp. 173-182 More about this Journal
Abstract
We have shown that long-term intake of Korean red ginseng (KRG) delays disease progression in HIV-I infected patients. In the present study to investigate whether this slow progression was associated with protective human leukocyte antigen (HLA) alleles as well as with KRG-intake, we have performed clinical analysis of 31 HIV-1 infected patients who have been living for more than 10 years without any antiretroviral therapy. Average amount of KRG-intake over $130\;{\pm}16$ months was $4,797\;{\pm}4,921\;g$ and the annual decrease in CD4 T cell (AD) was $30\;{\pm}29{\mu}L$. We observed significant correlations among amount of KRG-intake, AD(r=-0.53, P < 0.01), and plasma HIV-1 RNA copy (r=-0.35, P < 0.05), along with a significant correlation between KRG-intake and HLA score AD(r=-0.49, P < 0.01), whereas there was no significant correlation between HLA score and AD or viral load. When the 31 patients were divided into 2 groups based on the amount of KRG-intake, the $AD(14/{\mu}L)$ in the 16 patients who had taken higher amounts of KRG was significantly less than that $(49/{\mu}L)$ in the 15 patients with a little or no KRG-intake (P < 0.01). These data indicate that KRG-intake sig­nificantly slows CD4 T cell depletion in HIV-1 infected patients.
Keywords
Korean red ginseng; HLA; HIV-1 RNA; CD4 T cells; Correlation;
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