White Ginseng Saponin Upregulated the Production of -TNFTNF-α, IL-1β and NO in Primary Cultures of Mixed Glial Cells
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성정훈
(고려대학교 의과대학 약리학교실)
최동희 (고려대학교 의과대학 약리학교실) 김동훈 (고려대학교 의과대학 약리학교실) 전보권 (고려대학교 의과대학 약리학교실) 최상현 (고려대학교 의과대학 약리학교실) |
1 | Gillis, C. N. : Panax ginseng pharmacology: a nitric oxide link? Biochem. Pharmacol. 54, 1-8 (1997) DOI ScienceOn |
2 | McCarthy, K. D. and de Vellis, J.: Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J. Cell Biol. 85, 890-902 (1980) DOI ScienceOn |
3 | Giulian, D. and Baker, T. J.: Characterization of ameboid microglia isolated from developing mammalian brain. J. Neurosci. 6, 2163-2178 (1986) |
4 | Ramakers, G. J. A. and Moolenaar, W. H. : Regulation of astrocyte morphology by RhoA and lysophosphatidic acid. Exp. Cell Res. 245, 252-262 (1998) DOI ScienceOn |
5 | Cechin, S. R., Gottfried, C., Prestes, C. C., Wofchuk, S. T., Andrighetti, L. and Rodnight, R. : Astrocyte stellation in saline media lacking bicarbonate: possible relation to intracellular pH and tyrosine phosphorylation. Brain Res. 946, 12-23 (2002) DOI ScienceOn |
6 | Eng, L. F. and Ghirnikar, R. S. : GFAP and astrogliosis. Brain Pathol. 4, 229-237 (1994) DOI ScienceOn |
7 | Norton, W. T., Aquino, D. A., Hozuni, I., Chiu, F. C. and Brosnan, C. F. : Quantitative aspects of reactive gliosis: a review. Neurochem. Res. 17, 877-885 (1992) DOI |
8 | Norenberg, M. D.: Immunology of the nervous system. p.173-199. Oxford University Press, New York (1997) |
9 | Perry, V. H. and Gordon, S.: Immunology of the nervous system. p.155-172. Oxford University Press, New York (1997) |
10 | Benveniste, E. N.: Immunology of the nervous system. p.419-459. Oxford University Press, New York (1997) |
11 | Benveniste, E. N.: Cytokine actions in the central nervous system. Cytokine Growth Factor Rev. 9, 259-275 (1998) DOI ScienceOn |
12 | Murphy, S., Simmons, M. L., Agullo, L., Garcia, A., Feinstein, D. L., Galea, E., Reis, D. J., Minc-Golomb, D. and Schwartz, J. P.: Synthesis of nitric oxide in CNS glial cells. Trends Neurosci. 16, 323-328 (1993) DOI ScienceOn |
13 | Chen, X. : Cardiovascular protection by ginsenosides and their nitric oxide releasing action. Clin. Exp. Pharmacol. Physiol. 23, 728-732 (1996) DOI ScienceOn |
14 |
Kim, N. D., Kang, S. Y., Park, J. H. and Schini-Kerth, V. B. : Ginsenoside |
15 | Ndkajima, S., Uchiyama, Y., Yoshida, K., Mizukawa, H. and Haruki, E. : The effects of ginseng radix rubra on human vascular endothelial cells. Am. J. Chin. Med. 26, 365-373 (1998) DOI ScienceOn |
16 | Kang, S. Y., Schini-Kerth, V. B. and Kim, N. D. : Ginsenosides of the protopanaxatriol group cause endothelium-dependent relaxation in the rat aorta. Life Sci. 56, 1577-1586 (1995) DOI ScienceOn |
17 | Ventura, R. and Harris, K. M.: Three-dimensional relationships between hippocampal synapses and astrocytes. J. Neurosci. 19, 6897-6906 (1999) |
18 | Gasser, U. E. and Hatten, M. E. : Neuron-glia interactions of rat hippocampal cells in vitro: glial-guided neuronal migration and neuronal regulation of glial differentiation. J. Neurosci. 10, 1276-1285 (1990) |
19 | Mi, H., Haeberle, H. and Barres, B. A. : Induction of astrocyte differentiation by endothelial cells. J. Neurosci. 21, 1538-1547 (2001) |
20 | Mason, C. A., Edmondson, J. C. and Hatten, M. E. : The extending astroglial process: development of glial cell shape, the growing tip, and interactions with neurons. J. Neurosci. 8, 3124-3134 (1988) |
21 | Janzer, R. C. and Raff, M. C. : Astrocytes induce blood-brain barrier properties in endothelial cells. Nature 325, 253-257 (1987) DOI ScienceOn |
22 |
Park, Y. C., Lee, C. H., Kang, H. S., Kim, K. W., Chung, H. T. and Kim, H. D. : Ginsenoside- |
23 |
Kim, Y. C., Kim, S. R., Markelonis, G. J. and Oh, T. H. : Ginsenosides |
24 | Chen, X., Salwinski, S. and Lee, T. J. : Extracts of Ginkgo biloba and ginsenosides exert cerebral vasorelaxation via a nitric oxide pathway. Clin. Exp. Pharmacol. Physiol. 24, 958-959 (1997) DOI ScienceOn |
25 |
Fan, Z. H., Isobe, K., Kiuchi, K. and Nakashima, I. : Enhancement of nitric oxide production from activated macrophages by a purified form of ginsenoside |
26 | Isobe, I., Maeno, Y., Nagao, M., Iwasa, M., Koyama, H., Seko-Nakamura, Y. and Monma-Ohtaki, J. : Cytoplasmic vacuolation in cultured rat astrocytes induced by an organophosphorus agent requires extracellular signal-regulated kinase activation. Toxicol. Appl. Pharmacol. 193, 383-392 (2003) DOI ScienceOn |
27 | Possel, H., Noack, H., Putzke, J., Wolf, G. and Sies, H. : Selective upregulation of inducible nitric oxide synthase(iNOS) by lipopolysaccharide(LPS) and cytokines in microglia: in vitro and in vivo studies. Glia 32, 51-59 (2000) DOI ScienceOn |
28 | Kim, H., Chen, X., Gillis, C. N. : Ginsenosides protect pulmonary vascular endothelium against free radical-induced injury. Biochem. Biophys. Res. Commun. 189, 670-676 (1992) DOI ScienceOn |
29 | Choi, S. H., Choi, D. H., Song, K. S., Shin, K. H. and Chun, B. G. : Zaprinast, an inhibitor of cGMP-selective phosphodiesterases, enhances the secretion of TNF-alpha and IL-Ibeta and the expression of iNOS and MHC class II molecules in rat microglial cells. J. Neurosci. Res. 67, 411-421 (2002) DOI ScienceOn |
30 | Jeon, B. H., Kim, C. S., Kim, H. S., Park, J. B. Nam, K. Y. and Chang, S. J. : Effect of Korean red ginseng on blood pressure and nitric oxide production. Acta. Pharmacol. Sin. 21, 1095-1100 (2000) |
31 | Han, S. W. and Kim, H. : Ginsenosides stimulate endogenous production of nitric oxide in rat kidney. Int. J. Biochem. Cell Biol. 28, 573-580 (1996) DOI ScienceOn |
32 | Sonoda, Y., Kasahara, T., Mukaida, N., Shimizu, N., Tomoda, M. and Takeda, T. : Stimulation of interleukin-8 production by acidic polysaccharides from the root of Panax ginseng. Immunopharmacology 38, 287-294 (1998) DOI ScienceOn |
33 | Kim, D. H., Jung, J. S., Suh, H. W., Huh, S. O., Min, S. K., Son, B. K., Park, J. H., Kim, N. D., Kim, Y. H. and Song, D. K. : Inhibition of stress-induced plasma corticosterone levels by ginsenosides in mice: involvement of nitric oxide. Neuroreport 9, 2261-2264 (1998) DOI ScienceOn |
34 | Kim, K. H., Lee, Y. S., Jung, I. S., Park, S. Y., Chung, H. Y., Lee, I. R. and Yun, Y. S. : Acidic polysaccharide from Panax ginseng, ginsan, induces Th1 cell and macrophage cytokines and generates LAK cells in synergy with rIL-2. Planta Med. 64, 110-115 (1998) DOI ScienceOn |
35 | Lee, Y. S., Chung, I. S., Lee, I. R., Kim, K. H., Hong. W. S. and Yun, Y. S. : Activation of multiple effector pathways of immune system by the antineoplastic immunostimulator acidic polysaccharide ginsan isolated from Panax ginseng. Anticancer Res. 17, 323-331 (1997) |
36 | Cho, S. H., Choi, S. H., Choi, J. W., Kim, D. H., Shin, K. H., Chun, Y. S. and Chun, B. G. : Effect of Panax ginseng on latency of passive avoidance response and neuronal damage of hippocampus. Korea J. Physiol. Pharmacol. 1, 345-353 (1997) |
37 | Yun, Y. S., Lee, Y. S., Jo, S. K. and Jung, I. S. : Inhibition of autochthonous tumor by ethanol insoluble fractin from Panax ginseng as an immunomodulator. Planta Med. 59, 521-524 (1993) DOI ScienceOn |
38 | Murphy, S. : Production of nitric oxide by glial cells: regulation and potential roles in the CNS. Glia 29, 1-13 (2000) DOI ScienceOn |
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