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http://dx.doi.org/10.5142/JGR.2002.26.3.111

Clinical Applications and Efficacy of Korean Ginseng  

Nam, Ki-Yeul (Korea Ginseng and Tobacco Research Institute, Science Town)
Publication Information
Journal of Ginseng Research / v.26, no.3, 2002 , pp. 111-131 More about this Journal
Abstract
Korean ginseng (Panax ginseng C.A. Meyer) received a great deal of attention from the Orient and West as a tonic agent, health food and/or alternative herbal therapeutic agent. However, controversy with respect to scientific evidence on pharmacological effects especially, evaluation of clinical efficacy and the methodological approach still remains to be solved. Author reviewed those articles published since 1980 when pharmacodynamic studies on ginseng have intensively started. Special concern was paid on metabolic disorders including diabetes mellitus, circulatory disorders, malignant tumor, sexual dysfunction, and physical and mental performance to give clear information to those who are interested in pharmacological study of ginseng and to promote its clinical use. With respect to chronic diseases such as diabetes mellitus, atherosclerosis, high blood pressure, malignant disorders, and sexual disorders, it seems that ginseng plays preventive and restorative role rather than therapeutics. Particularly, ginseng plays a significant role in ameliorating subjective symptoms and preventing quality of life from deteriorating by long term exposure of chemical therapeutic agents. Also it seems that the potency of ginseng is mild, therefore it could be more effective when used concomitantly with conventional therapy. Clinical studies on the tonic effect of ginseng on work performance demonstrated that physical and mental dysfunction induced by various stresses are improved by increasing adaptability of physical condition. However, the results obtained from clinical studies cannot be mentioned in the indication, which are variable upon the scientist who performed those studies. In this respect, standardized ginseng product and providing planning of the systematic clinical research in double-blind randomized controlled trials are needed to assess the real efficacy for proposing ginseng indication. Pharmacological mode of action of ginseng has not yet been fully elucidated. Pharmacodynamic and pharmacokinetic researches reveal that the role of ginseng not seem to be confined to a given single organ. It has been known that ginseng plays a beneficial role in such general organs as central nervous, endocrine, metabolic, immune systems, which means ginseng improves general physical and mental conditons. Such multivalent effect of ginseng can be attributed to the main active component of ginseng,ginsenosides or non-saponin compounds which are also recently suggested to be another active ingredients. As is generally the similar case with other herbal medicines, effects of ginseng cannot be attributed as a given single compound or group of components. Diversified ingredients play synergistic or antagonistic role each other and act in harmonized manner. A few cases of adverse effect in clinical uses are reported, however, it is not observed when standardized ginseng products are used and recommended dose was administered. Unfavorable interaction with other drugs has also been suggested, which the information on the products and administered dosage are not available. However, efficacy, safety, interaction or contraindication with other medicines has to be more intensively investigated in order to promote clinical application of ginseng. For example, daily recommended doses per day are not agreement as 1-2g in the West and 3-6 g in the Orient. Duration of administration also seems variable according to the purpose. Two to three months are generally recommended to feel the benefit but time- and dose-dependent effects of ginseng still need to be solved from now on. Furthermore, the effect of ginsenosides transformed by the intestinal microflora, and differential effect associated with ginsenosides content and its composition also should be clinically evaluated in the future. In conclusion, the more wide-spread use of ginseng as a herbal medicine or nutraceutical supplement warrants the more rigorous investigations to assess its effacy and safety. In addition, a careful quality control of ginseng preparations should be done to ensure an acceptable standardization of commercial products.
Keywords
Panax ginseng; Korean ginseng; pharmacodynamic; climical efficacy; safety; indication;
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1 Smith, M., Boon, H. S. : Patient Education and Counseling, 38, 109 (1999)   DOI   ScienceOn
2 Allen, J. D., et al. :J of the America College of Nutrition 17(5), 462 (1998)   DOI
3 Fouad, A A, et al. :Alex J Pharm Sci 10(3), 219 (1996)
4 Forgo, I., et al. : Mediziniscle Welt 32, 751 (1981)
5 Brekhman, I. I. : Proceedings of Ginseng, Symposium of Geronotology, Lugano, The Research Institute, Office of Monopoly, ROK, 5 (1976)
6 Mochizuki, M., Yoo, Y. c., Matsuzawa, K, Sato, K., Saiki, I., Iono-Oka, S., Samukawa, K. and Azuma, I. : Biol Pharm Bull 18(9), 1197 (1995)   DOI   ScienceOn
7 Wakabayashi, C., Hasegawa, H., Murata, J, and Saiki, I. : Oncology Research 9, 411 (1997).
8 Hasegawa, H., Lee, K S., Nagaoka, T., Tezuka, Y., Uchiyama, M., Kadota, S., Saiki, I. : Biol Pharm Bull 23(3), 298 (2000)   DOI   ScienceOn
9 Wiklund, I. K, Mattsson, L. A, Lindgren, R, Limoni, C. : International J of Clinical Pharmacology Research, 19(3), 89 (1999)
10 Jin, S. H., Park, J. K, Nam, K. Y., et al. : J of Ethnopharmacology 66, 123 (1999)   DOI   ScienceOn
11 Chepurnov, S. A, et al.: Bulletin of Expermenial Biology and Medicine, 122(9), 872 (1996)   DOI
12 Ono, T., et al. : Physiology & Behavior 69, 555 (2000)
13 Wen, T. c., Yoshimura, H., Matsuda, S., Lim, J. H. and Sakanmaka, H. : Acta Neuropathol 91, 15 (1996)
14 Sorensen, H. and Sonne, J.: Current Therapeutic Research, 57(12), 959 (1996)   DOI   ScienceOn
15 Kennedy, D., Scholey, A., Wesne, K A: Phytomed 7(Suppl. II), 105 (2000)
16 Sakada, T., Sunega, K, Yoshimatsu, H.: Proc. '99 Korean Japan Ginseng Symp., 32 (1999)
17 Awang, Dennis, V. C. : JAMA, 266(3), 363 (1991)   DOI
18 Nam, K. Y. and Park, J. D.: J Ginseng Res. 24(2), 99 (2000)
19 Cui, J., Garle, M., Eneroth, P., Bjorkhem, L.: The LANCET, 344, 134 (1994)   DOI   ScienceOn
20 Cui, J. E., Garle, M., Bjorkhem, I. and Invest, P. : Scand J Lab Invest 56, 151 (1996)   DOI
21 Yano S. : Biomedicine & Therapeutics (Japan), 28(1), 63(1995)
22 Kimura, M. and Suzuki,J : Advancesin Chinese Medicinal Materials Research edited by H.W. Chang, H W. Heung, W. W. Tso and A Koo. World Scientific Publ. Co., Singapore, 181 (1985)
23 Sotaniemi, E. A., Haapakoski, E., Rautio, A. R. : Diabetes Care 18(10), 1373 (1995)   DOI   ScienceOn
24 Vuksan, V., Sung, M. K., Sievenpier,J. L., Buono, M. D. : Experimental Biology2002$\circledR $ New Orleans, Louisina April 20-24, Abstracts Part I, A647 (2002)
25 Yoshita, Y., et al. : Kisho & Linshiou, 16(10), 302 (1982)
26 Yamamoto, M., et al. : Kisho & Linshiou, 17(6), 169 (1983)
27 Okuda, H., Yoshida, R. : Proc. of the 2nd Int'l Ginseng Symp., Seoul, Korea, 53 (1980)
28 남기열 : 최신고려인삼(성분과 효능편), 천일인쇄소, p. 56 (1996)
29 Choi, D. S., Kim, S. J., Lee, K J., et al. : Proc fih Int, I Symp., Seoul, Korea, 102 (1993)
30 Choi, K M., Lee, E. J., Kim, Y. H., et al. : Korean J. Ginseng Sci. 21(3), 153 (1997)
31 Tetsutani, T., et al. : The Ginseng Review 10, 14 (1990)
32 Joo, C. N., Kang, I. C. and Lee, H. B : Korean J. Ginseng Sci. 12(2), 104 (1988)
33 Nagata, K, et al.: Proc. of '97 Korea-Japan Ginseng Symp., 58 (1997)
34 Oh, B. H., Han, K H., Kim, Y. J. and Nam, K. Y. : Proc. of '99 Korea-Japan Ginseng Symposium, Seoul, Korea, 70 (1999)
35 Chang, Y. S., et al. : Proc. of the 3rd Intl' Ginseng Symp. Seoul, 197 (1980)
36 No, H. T., et al. : The New Medical J. 35(2), 40 (1992)
37 Nocerino, E., Amato, M. and Izzo, A A. : Fitoterapia 71, S1 (2000)
38 Lee, H. Y., Pack, J. S. and Lee, S. W. : Korean J of Ural. 29(6), 950 (1988)
39 Phamacopoeia of the People's Republic of China (English ed. 1997) Volume 1, Compliled by the Pharmacopoeia Commission Of PRC, Chemical Industry Press Beijing, China, 151 (1997)
40 Gillis, C. N. : Biochem Pharmacol, 54, 1 (1997)
41 Kim (Jun), H. Y., Chen, X. and Gillis, C. N. : Biochemical and Biophysical Research Communations 189(2), 670(1992)   DOI   ScienceOn
42 Jeon, R. H., Kim, C. S., Kim, H. S., Park, J. B., Nam, K. Y. and Chang, S. J. : Acta Pharmacol Sin 21(2), 1095 (2000)
43 Oh, B. H., Zo, J. H., Han, K. H., Kim, C. H., Nam, K. Y. and Seo, J. D. : The Ginseng Review 27, 67 (1999)
44 高橋榮司 : The Ginseng Review, 6, 25 (1988)
45 Kaneko : The Ginseng Review, 2, 183 (1984)
46 Kim, N. D., Kim, B. K. and Lee, H. S. : Yakhak Hoeji 26(4), 239 (1982)
47 Zhang, J. M., Matsuura, Y., Sueda, T., Orihashi, K, Fukunaga, S. and Watanabe, M. : Hiroshima J. Med. Sci. 48(2), 65 (1999)
48 Yamamoto, M., et al. : Japanese J Arteriosclerosis 9(4), 671 (1981)
49 Joo, C. N., Lee, H. R, Lee, Y. Wand Kang, I. C. : Proc. 5th Int'l Ginseng Symp., Seoul, Korea, 47 (1988)
50 Beltz, S. D. and Doering, P. L. : Clinical Pharmacy 12, 900(1993)
51 Yoon, S. H. and Joo, C. N. : Korean J. Ginseng Sci. 17(1), 1 (1993)
52 Koo, J. H,, Noh, Y. H. and Lim, G. : Proc. of Korean-Japan Ginseng Symp. : Seoul, Korea, 91 (1997)
53 Kwon, B. M., Kim, M. K, Nam, I. B., Kim, D. S., Park, J.D., Kim, Y. K, Lee, H. K, Kim, S. I. : Bioorganic & Medicinal Chemistry Letters 9, 1375 (1999)   DOI   ScienceOn
54 Kwon, B. M., Ro, S. H., Kim, M. K., Nam, J. Y. and Bok, S. H. : Planta Med. 63, 552 (1997)   DOI   ScienceOn
55 Nakanishi, K, et al. : Linshio & Kenkyhu 57(9), 323(1980)
56 Jin, E. Y., Shi, Z. X., Ke, Y. N., Huang, L. H., Yan, X. P., Wei, Y. L., Jin, M., Liu, P., Yang, L. X., Lee, K S., Nam, K. Y., Kumagai, A. : The Ginseng Review 24, 104 (1998)
57 Yamamoto, M. and Kumagai, A. : Proc. 4th Int'l Ginseng Symp., Seoul, Korea, 13 (1984)
58 Ishigami, J., Saito, H., Karnidono, S. : 日本不班學會雜誌 16(4), 45 (1971)
59 Yang, B. C., Li, Y. J. and Chen, X. : Asia Pacific Journal of Pharmacology. 4, 265 (1989)
60 이광수 : 인삼시험연구 용역보고서 (인삼이 심장비대증에 미치는 약리작용에 관한연구). 한국인삼연초연구소, 1981
61 Shida, K, et al. ; 日本不任學會雜誌 16, 85 (1970)
62 Ishigami, J., et al: Clinical Evaluation, 5(2), 205 (1977)
63 Salvati, G., Genovesi, G., Marcellini, E, De, Nuccio, I., Pepe, M. and Re, M. : Panminerva Med 38(4), 249 (1996)
64 Brekhman, I. I. and Dardymov, I. V. : Ann Rev Pharmacol 69, 419 (1969)
65 Wagner, H., Norr, H. and Winterhoff, H.: Phytomedicine 1, 63 (1994)   DOI
66 Fulder, S. J., et al. ;Proc. 3rd Int'l Ginseng Symp. Seoul, Korea, 81 (1980)
67 Yun, T. K. and Choi, S. Y. : International Epidemiological Association 27, 359 (1998)
68 Yun, T. K. : The Lancet Oncology 21(1), 49 (2001)   DOI   ScienceOn
69 Lee, B. M., Lee, S. K, Kim, H. S. : Cancer Letters 132, 219 (1998)
70 山本 裕士, 片野 光男, 松永尙: 藥用A參’89, 共立出版, 東京, p. 220-223 (1989)
71 Chang, Y. S., et al. :Korean J of Ob.& Gyn. 21(4), 253 (1978)
72 Katano, M. and Yamamoto, H.: Linshio & Kenkyhu 64(7), 271 (1988)
73 Suh, S.O., Jeung, C. H. and Soo, G. S.: The Ginseng Review. 25, 78 (1998)
74 Yun, T. K, Lee, Y. H., Kim, S. I., Yun, H. Y. : J Korean Med Sci 16(Suppl), S66 (2001)   DOI
75 Wesnes, K. A, Ward, T., McGinty, A., Petrini, O. : Psycopharmacology 152, 353 (2000)
76 Lee, Tze-fun, Shiao, Young-ji, Chen, Chieh-Fu, Wang Lawrence, C. H. : Planta Medica 67, 634 (2000)
77 Ott, B. R. and Owens, N. : J of Geritric Psychology and Neurology 11, 163 (1998)   DOI
78 Gonzalez-Seijo, J. C., Ramos, Y. M. and Lastra, 1. : J Clin Psychopharmacol, 15(6), 447 (1995)   DOI
79 Ryu, S. J. and Chien, Y. Y.:Neurology, 45, 829 (1995)
80 Koren, G., et al. : JAMA, 264(22), 2866 (1990)   DOI
81 Lee, B. H., Lee, S. J., Hui, J. H., Lee, S. Y., Sung, J. H., Hun, J, D. and Moon, C. K.: Planta Medica 64, 500 (1998)   DOI   ScienceOn
82 Kim, K. W, Lee, Y. S., Jung, I. S., Park, S. Y., Chung, H. Y., Lee, L R. and Yun, Y. S. : Plania Medica 64, 110 (1998)   DOI   ScienceOn
83 Lee, Y. S., Chung, I. S., Lee, I. R., Kim, K. H., Hong, W. S., Yun, Y. S.: Anticancer Res. 17, 323 (1997)
84 Park, K. M., Kim, Y. S., Jeong, T. C., Joe, c. H., Shin, H. J., Lee, Y. H., Nam, K. Y. : Planta Medica 67, 122 (2000)   DOI   ScienceOn
85 Kim, K. W, Jung, I. S., Chung, H. Y., Jo, S. K and Yun, Y. S. : Korean J. Ginseng Sci. 21(2), 78 (1997)
86 Yamamoto, M., et al. : The Ginseng Review 9, 15 (1990)
87 Sigel, R. K :J. of American Medical Association 241(15), 1614 (1979)   DOI
88 Sigel, R. K. : Proc. 3rd Int'l Ginseng symp, Seoul, Korea, 229 (1980)
89 Owen, R. T. : Drugs of Today 27(8), 343 (1981).
90 Kaneko, H., Nakanishi, K, Kuwashima, K, et at. : Linsho & Kenkyu 58(12), 145 (1983)
91 Jin, E. Y., Jin, M., Wei, Y. L., Huang, L. H., Yan, X. P., Shi, Z. X., Huang, L., Shen, D. C., Fu, R. J., Zhao, T. Y., Nam, K. Y. and Kumagai, A. : Advances in Ginseng Research, Proc. of the 7th Intl' Symp. on Ginseng, 22 (1998)
92 Han, K. H., Choe, S. C., Kim, K. D., Sohn, D. W, Nam, K. Y., Oh, B. H., Lee, M. M., Park, Y. B., Choi, Y. S., Seo, J. D. and Lee, Y. W. : American J. of Chinese Medicine, 26(2), 199 (1998)   DOI   ScienceOn
93 Sohn, E. S., Huh, B. Y., Park, S. C., Park, C. W.and Kim, H. J. : Proc. 2nd Int'l Ginseng Symp. : 1 (1980)
94 Imamura, Y. and Kuwashima, K : Proc. of the 5th Intl' Ginseng Symp. Seoul, 87 (1988)
95 Kim, N. D. : Proc. of '99 Korea-Japan Ginseng Symp., 1 (1999)
96 Tetsutani, T., et al. : The Ginseng Review 22, 119 (1996)
97 Tetsutani, T., Yammmamura, M., Yamaguchi, T., Suzuki, S., Makino, H. and Onoyama, O. : The Ginseng Review 27, 86 (1999)
98 Tetsutani, T, Yammmamura, M., Yamaguchi, T, Suzuki, S. and Onoyama O: The Ginseng Review 25, 28 (1998)
99 Tetsutani, T, Yammmamura, M., Yamaguchi, T, Suzuki, S., Onoyama, O. and Kono M : The Ginseng Review 28, Japan, 44 (2000)
100 Scaglione, E, Ferrara, E, Dugnani, S., Santoro, G., Frachini, E: Drugs Exptr Clin Res 16(10), 537 (1990)
101 Cho, Y. K, et al. :Int'l Immunopharmacology 1 (2001)
102 Cho, Y. K, et al. : J. of Korean Association of Cancer Prevention, 1, 131 (1997)
103 Dorling, E., et al. : Notabene Medici 10, 245 (1980)
104 Morue, S. : Acta Physiol Lat. Am. 34, 521 (1983)
105 Bucci, L. R: Am. J Clin. Nutr. 72(Suppl), S624 (2000)   DOI
106 Carso, Masco, A, et al.: Drugs Expt; Clin. Res. 22(6), 323 (1996)
107 Tode, T., Kikuchi, Y., Hirata, J., Kita, T. and Nagata, I. : Int J Gynecol Obstet 67, 169 (1999)   DOI   ScienceOn
108 Chen, X., Lee, T. J. E: Br J Pharmacol 115, 15 (1995)
109 Choi, Y. D., Xin, Z. C. and Choi, H. K: Int'l J Impotence Research 10, 37 (1998).
110 Choi, Y. D., Rha, K. H. and Choi, H. K.: The Journal of Urology 162, 1508 (1999)   DOI   ScienceOn
111 Yoshimura, H., Kimura, N. and Sugiura, K.:Meth Find Clin Pharmacol 20(1), 59 (1998)   DOI
112 Yoshimura, H. and Kimura, N.: The Ginseng Review 14, 100 (1992)
113 Choi, H. K, Seong, D. H. and Rha, K. H.: Int. J. Impotence Res. 7, 181 (1995)
114 Kim, S. W. and Paick, J. S. : Kor J Androl. 17(1), 23(1999)
115 Shinkai, K, Akedo, H., Mukai, M., Imamura, E, lsoai, A., Kobayashi, M. and Kitagawa, I. : Jpn J Cancer Res 87, 357 (1996)   DOI
116 Kim, Y. S., Kim, D. S. and Kim, S. I. : The International J. of Biochemistry & Cell Biology 30, 327 (1998)   DOI   ScienceOn
117 Park, J, A., Lee, K. Y., Oh, Y. I., Kim, K. W. and Kim, S. I. : Cancer Letters 121, 73 (1997)   DOI   ScienceOn
118 Lee, K. Y., Lee S. K.: Anticancer Res 17(2), 1067 (1997)
119 Kanaoka, M., Akao, T. and Kobashi, K. : J. of Traditional Medicine 11, 241 (1994)
120 Sato, K, Mochizuki, M., Saiki, I., Yoo, Y. C., Samukawa, K. and Azuma, I.: Biol Pharm Bull 17(5), 635 (1994)   DOI   ScienceOn
121 대한약전외 생약규격집(주해서) : 지형준, 이상인 편저, 한국메디칼인텍스사, 518 (1988)
122 中華人民共和國藥典(1部) : 國家藥典委員會 編, 化學工業出版社(北京), p. 6-7, p. 121 (2000)
123 日本藥局方解說書: 光川書店(東京), D-302-304, D-714 (1991)
124 The Complete German Commission E Monographs : American Botanical Council, Austin, 138 (1998)
125 World Health Organization: WHO Monographs on selected medicinal plants, Radix Ginseng Vol. 1. WHO, Geneva., 168 (1999)
126 Harkey, M. R., Henderson, G. L., et al : The American J. of Clinical Nutrition, 73, 1101 (2001)   DOI
127 Khan, I. A., Allgood, J., et al. : J. of AOAC International, 84, 936 (2001)
128 Cui, J, E, Garle, M., Bjorkhem, L, Eneroth, P. : Scan J Clin Invest, 56, 151 (1996)   DOI
129 Ding, K. T., Shen, T. K, Cui, Y. Z. : 中國中西醫結合雜誌, 15(6), 325 (1995)
130 Yamamoto, M., Uemura, T, Nakama, S., Uerniya, M. and Kumagai, A. : American J of Chinese Medicine 9(1-4), 96 (1983)
131 Shin, H. R. et al. : Cancer Causes and Control 11, 565 (2000)
132 Yun, T. K : Nutrition Reviews 54(1), S71 (1996)   DOI
133 Chen, X., Liu, H., Lei, X., Fu, Z., Li, Y., Tao, L. and Han, R. : J. of Ethnopharmacology 60, 71 (1998)
134 Li, W., Wanibuchi, H., Salim, E. I., Wei, M., Yamamoto, S., Nishino, H. and Fukushima, S. : Nutrion and Cancer, 36(1), 66 (2000)   DOI   ScienceOn
135 Wu, X. G., Zhu, D. H., Li, X. : J Korean Med Sci 16(Suppl), S66 (2001)
136 Nishino, H., et al. : J Korean Med Sci 16(Suppl), S66 (2001)
137 Yun, T. K. and Choi, S. Y.: Int'l J of Epidemiology 19(4),871 (1990)   DOI
138 Yun, T. K. and Choi, S. Y. : Cancer Epidemiology, Biomakers & Prevention 4, 401 (1995)
139 Yamamoto, M., et al. : Kisho & Linshiou 17(6), 178 (1983)
140 Kaneko, H., et al. : Linshio&Kenkyhu, 60(12), 170 (1983)
141 Tamura, Y., Hirai, A., Terano, T., Tahara, K, Saitoh, J., Kondo, S., Samukawa, K and Yoshida, S. : Proc. 6th Int'l Ginseng Symp., Seoul, Korea, 28 (1993)
142 田村泰, 平井愛山, 山本 恭平, 吉田 尙: 和漢醫學雜誌, 5, 260 (1988)
143 Yamamoto, M. : The Ginseng Review, 24, 129-132 (1998)
144 Punnonen, R. and Lukola, A. : Asia-Oceania. Gynaecol. 10(3), 399 (1984)
145 Park, J. D., Kim, Y. S., Park, K. M., Shin, H. J., Jeong, T. C., Lee, Y. H. and Nam, K Y. : Proc. of '99 KoreaGinseng Symp., 191 (1999)
146 Hong, B., Ji, Y. H., Hong, J. H., Nam, K Y. and Ahn, T. Y. : 8th Asia-Pacific Society for Impotence Research & Exhibition (APSIR), Sexual Dysfunction for the New millenium October 23rd-26th, 2001, Phuket. Thailand, Abstract Book OR3 (2001)
147 Choi, H. K and Choi, Y. D.: Proceedings of '99 Korea-Japan Ginseng Symposium, 97 (1999)
148 Lee, H. Y. and Kim, C. S. : Korean J of Urol, 27(2), 235 (1986)
149 Tode, T., Kikuchi, Y., Kita, T., Hirata, J., Imaizumi, E., Nagata, I.:J. Cancer Res. Clin Oncol. 120, 24 (1993)   DOI   ScienceOn
150 Rhee, Y. H., Choe, J. H., Kang, K. W. and Joe, C. : Planta Medica 57, 125 (1991)
151 Kaneko, H., et al. : Linshiou & Kenkyu, 59(12), 137 (1984)
152 Pieralisi, G., et at. : Clin. Therap. 13, 373 (1991)
153 Kaneko, H., Nakanishi, K, et al. : Proc. '97 Korean-Japan Ginseng Symp. 121 (1997)
154 Scaglione, E, et al. : Drugs Exptl Clin Res 22(2), 65 (1996)
155 金子仁: 日本醫事新報, NO 3918, 61 (1999)
156 Koike, Y., et al. : The Ginseng Review 25, 7 (1998)
157 Bahrke, M. and Morgan, W. E: Sports Med. 29(2), 113 (2000)   DOI   ScienceOn
158 Antonio, C, et al. : Comperatioe Biochemistry and Physiology, Part C 130, 369 (2001)
159 Ziemba, A w., et al. :Int'l J of Nutrition 9, 371 (1999)
160 Engels, H. and Wirth, J. C.:J Am Diet Assoc, 97, 1110 (1997)
161 Ioana, G., Carabin, George, A., Burdock and Chris, Chatzdakis : Internation J. of Toxicology, 19, 293 (2000)   DOI   ScienceOn
162 Shibata, S. : J Korean Med Sci 16(Suppl), S28 (2001)   DOI
163 TreatmentUpdate 119, 13(3), 3 (2001)
164 Sonnenbom, U. and Hansel : In De Smet PAGM et al., eds. Adverse Reaction of Herbal Drugs, Springer. Verlag, Berlin, 179 (1992)
165 Dega, R., et al. : The LANCET, 347, 1344 (1996)
166 Sonnenbom, U. and Proppert, Y. : British J of Pharmacology, 2(1), 3 (1991)
167 Watt, J., Bottomley, M., et at. : Br J Sp Med, 23(2), 76 (1988)   DOI   ScienceOn
168 Becker, B. N., et al. : JAMA, 276(3), 606 (1996)   DOI
169 Vogler, B. K, et al. : Eur J Clin Pharmacal 55, 567 (1999)   DOI
170 Jones, B. D., Runiks, A. M. : J Clin Psychopharmacol. 7, 201 (1987)   DOI
171 Janetzky, K, Morreale, A. P.: Am J Health-Syst Pharm. 54, 692 (1997)
172 Bae, E. A, Han, M. J., Choo, M. K., Park, S. Y. and Kim, D. H. : Biol Pharm Bull 25(1), 58 (2002)   DOI   ScienceOn
173 Karikura, M. : Chem. Pharm. Bull., 39, 2357 (1991)
174 Kaneko, H., Nakanishi, K, et al. : Ther Res 17, 405(1996)