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http://dx.doi.org/10.5624/isd.2017.47.2.135

Squamous cell carcinoma arising within a maxillary odontogenic keratocyst: A rare occurrence  

Jalali, Elnaz (Eliray Oral and Maxillofacial Radiology Consulting Services)
Ferneini, Elie M. (Department of Craniofacial Sciences, Division of Oral and Maxillofacial Surgery, University of Connecticut, School of Dental Medicine)
Rengasamy, Kandasamy (Section of Oral and Maxillofacial Radiology, University of Connecticut, School of Dental Medicine)
Tadinada, Aditya (Section of Oral and Maxillofacial Radiology, University of Connecticut, School of Dental Medicine)
Publication Information
Imaging Science in Dentistry / v.47, no.2, 2017 , pp. 135-140 More about this Journal
Abstract
Squamous cell carcinoma (SCC) arising within the lining of an odontogenic keratocyst (OKC) is a rare occurrence. Although potentially locally destructive, OKC is a benign odontogenic process that typically presents with clinical and radiographic features characteristic of a benign intraosseous neoplasm. We present the clinical and radiographic features of a maxillary mass that demonstrated SCC arising from the lining of an OKC. Although the initial clinical and radiographic presentation suggested an infection or malignant neoplasm, biopsies revealed an infiltrative well-differentiated SCC contiguous with and arising from the focus of a pre-existing OKC. The patient subsequently underwent a type II hemi-maxillectomy with neoadjuvant chemoradiation. This report discusses the clinical and radiographic features associated with intraosseous malignancies, especially those arising from an otherwise benign odontogenic lesion. While the majority of OKCs are benign, the current report illustrates the potential for carcinomatous transformation within the lining of an OKC.
Keywords
Carcinoma; Squamous Cell; Odontogenic Cysts; Maxilla; Cell Transformation; Neoplastic;
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1 Maurette PE, Jorge J, de Moraes M. Conservative treatment protocol of odontogenic keratocyst: a preliminary study. J Oral Maxillofac Surg 2006; 64: 379- 83.   DOI
2 Habibi A, Saghravanian N, Habibi M, Mellati E, Habibi M. Keratocystic odontogenic tumor: a 10-year retrospective study of 83 cases in an Iranian population. J Oral Sci 2007; 49: 229-35.   DOI
3 Sharif FNj, Oliver R, Sweet C, Sharif MO. Interventions for the treatment of keratocystic odontogenic tumors (KCOT, odontogenic keratocyst (OKC)). Cochrane Database Syst Rev 2010; 9: CD008464.
4 Mendes RA, Carvalho JF, Van der Waal I. Characterization and management of the keratocystic odontogenic tumor in relation to its histological and biological features. Oral Oncol 2010; 46: 219-25.   DOI
5 Soskolne WA, Shear M. Observations on the pathogenesis of primordial cysts. Br Dent J 1967; 123: 321-6.
6 Chirapathomsakul D, Sastravaha P, Jansisyanont P. A review of odontogenic keratocysts and the behavior of recurrences. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 101: 5-10.   DOI
7 Shear M. The aggressive nature of the odontogenic keratocyst: is it a benign cystic neoplasm? Part 1. Clinical and early experimental evidence of aggressive behaviour. Oral Oncol 2002; 38: 219-26.   DOI
8 Browne RM, Gough NG. Malignant change in the epithelium of lining odontogenic cysts. Cancer 1972; 29: 1199-207.   DOI
9 Fanibunda K, Soames JV. Malignant and premalignant change in odontogenic cysts. J Oral Maxillofac Surg 1995; 53: 1469-72.   DOI
10 Falaki F, Delavarian Z, Salehinejad J, Saghafi S. Squamous cell carcinoma arising from an odontogenic keratocyst: a case report. Med Oral Pathol Oral Cir Bucal 2009; 14: E171-4.
11 Lee JW, Gates R, Wignall A. Squamous cell carcinoma arising from a keratocystic odontogenic tumor. Otolarygol Head Neck Surg 2011; 145: 356-7.   DOI
12 Batsakis JG, Rice DH, Solomon AR. The pathology of head and neck tumors: squamous and mucous-gland carcinomas of the nasal cavity, paranasal sinuses, and larynx, part 6. Head Neck Surg 1980; 2: 497-508.   DOI
13 Slootweg PJ, Richardon M. Squamous cell carcinoma of the upper aerodigestive system. In: Gnepp DR. Diagnostic surgical pathology of the head and neck. 2nd ed. Philadelphia, PA: Saunders Elsevier; 2009. p. 45-110.
14 Syrjanen KJ. HPV infections in benign and malignant sinonasal lesions. J Clin Pathol 2003; 56: 174-81.   DOI
15 Yoshida H, Onizawa K, Yusa H. Squamous cell carcinoma arising in association with an orthokeratinized odontogenic keratocyst. Report of a case. J Oral Maxillofac Surg 1996; 54: 647-51.   DOI
16 Mills SE. Neuroectodermal neoplasms of the head and neck with emphasis on neuroendocrine carcinomas. Mod Pathol 2002; 15: 264-78.   DOI
17 Agaram NP, Collins BM, Barnes L, Lomago D, Aldeeb D, Swalsky P, et al. Molecular analysis to demonstrate that odontogenic keratocysts are neoplastic. Arch Pathol Lab Med 2004; 128: 313-7.
18 Henley J, Summerlin DJ, Tomich C, Zhang S, Cheng L. Molecular evidence supporting the neoplastic nature of odontogenic keratocyst: a laser capture microdissection study of 15 cases. Histopathology 2005; 47: 582-6.   DOI
19 Minic AJ. Primary intraosseous squamous cell carcinoma arising in a mandibular keratocyst. Int J Oral Maxillofac Surg 1992; 21: 163-5.   DOI
20 Areen RG, McClatchey KD, Baker HI. Squamous cell carcinoma developing in an odontogenic keratocyst. Report of a case. Arch Otolaryngol 1981; 107: 568-9.   DOI
21 Makowski GJ, McGuff S, Van Sickels JE. Squamous cell carcinoma in a maxillary odontogenic keratocyst. J Oral Maxillofac Surg 2001; 50: 76-80.
22 Chaisuparat R, Coletti D, Kolokythas A, Ord RA, Nikitakis NG. Primary intraosseous odontogenic carcinoma arising in an odontogenic cyst or de novo: a clinicopathologic study of six new cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 101: 194-200.   DOI
23 Waldron CA, Mustoe TA. Primary intraosseous carcinoma of the mandible with probable origin in an odontogenic cyst. Oral Surg Oral Med Oral Pathol 1989; 67: 716-24.   DOI
24 McDonald AR, Pogrel MA, Carson J, Regezi J. p53-positive squamous cell carcinoma originating from an odontogenic cyst. J Oral Maxillofac Surg 1996; 54: 216-8.   DOI
25 Meara JG, Shah S, Li KK, Cunningham MJ. The odontogenic keratocyst: a 20-year clinicopathologic review. Laryngoscope 1998; 108: 280-3.   DOI
26 Sato T, Kamiya Y, Tochihara S, Tochihara S, Toyoda N, Asada K, et al. Primary intraosseous squamous cell carcinoma of the mandible: report of a case and review of the recent literature. Oral Med Pathol 2006; 11: 83-8.   DOI
27 Gomes CC, Diniz MG, Gomez RS. Review of the molecular pathogenesis of the odontogenic keratocyst. Oral Oncol 2009; 45: 1011-4.   DOI
28 Anand VK, Arrowood JP Jr, Krolls SO. Malignant potential of the odontogenic keratocyst. Otolaryngol Head Neck Surg 1994; 111: 124-9.   DOI
29 Ward TG, Cohen B. Squamous carcinoma in a mandibular cyst. Br J Oral Surg 1963; 1: 8-12.   DOI
30 Bodner L, Manor E, Shear M, van der Waal I. Primary intraosseous squamous cell carcinoma arising in an odontogenic cyst: a clinicopathologic analysis of 116 reported cases. J Oral Pathol Med 2011; 40: 733-8.   DOI
31 Thomas G, Pandey M, Mathew A, Abraham EK, Francis A, Somanathan T, et al. Primary intraosseous carcinoma of the jaw: pooled analysis of world literature and report of two new cases. Int J Oral Maxillofac Surg 2001; 30: 349-55.   DOI
32 Johnson LM, Sapp JP, Mcintre DM. Squamous cell carcinoma arising in a dentigerous cyst. J Oral Maxillofac Surg 1994; 52: 987-90.   DOI