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http://dx.doi.org/10.14478/ace.2022.1093

Recent Progress in Multiplexed Detection of Biomarkers Based on Quantum Dots  

Kim, Yerin (Department of Chemical Engineering, Myongji University)
Choi, Yu Rim (Department of Chemical Engineering, Myongji University)
Kim, Bong-Geun (Department of Chemical Engineering, Myongji University)
Na, Hyon Bin (Department of Chemical Engineering, Myongji University)
Publication Information
Applied Chemistry for Engineering / v.33, no.5, 2022 , pp. 451-458 More about this Journal
Abstract
Semiconductor quantum dots (QDs) are optical probes with excellent fluorescence properties. Therefore, they have been applied to various bio-medical imaging techniques and biosensors. Due to the unique optical characteristics of wide absorption and narrow fluorescence energy bands, multiple types of signals can be generated by the combination of fluorescence wavelengths from different QDs, which enables the simultaneous detection of more than two biomarkers. In this review, the advantages and applications of QDs and QD nanobeads (QBs) in multiple biomarker assays were described, and new developments or improvements in multiplexed biomarker detection techniques were summarized. In particular, recent reports were summarized, focusing on the design strategies in immunoassay construction and signal transducing materials for fluorescence-linked immunosorbent assays using QDs and immunochromatographic assays using QBs. New detection platforms will be developed for early diagnosis of diseases and other fields if multiplexed detection technologies of excellent accuracy and sensitivity are combined with artificial intelligence algorithms.
Keywords
Quantum dots; Quantum dot nanobeads; Multiplexing; Biomarker detection; Fluorescence;
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