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http://dx.doi.org/10.14478/ace.2021.1068

Preparation of Hydrated Liquid Crystalline Vesicles Containing High Content of Ceramide using a Solubilizer  

Park, Min Seon (Division of Chemistry and Cosmetics, Dongduk Women's University)
Jin, Byung Suk (Division of Chemistry and Cosmetics, Dongduk Women's University)
Publication Information
Applied Chemistry for Engineering / v.32, no.5, 2021 , pp. 541-546 More about this Journal
Abstract
Hydrated liquid crystalline vesicles containing a high content of ceramide were prepared by constituting an optimal composition in which ceramides can be mutually self-associated with phospholipid and cholesterol. From the result of manufacturing various vesicles with different component composition, when the edge activator sodium deoxycholate (SDOC) and the solubilizer PEG-60 hydrogenated castor oil (HCO 60) were mixed to form vesicles, the smallest nano-sized particles were produced and the vesicle dispersion solution was weakly acidic and maintained the most stable state. In addition, it was confirmed through polarized light microscopy and thermal analysis that the addition of SDOC and HCO 60 had an effect on the inhibition of crystallinity of lipid components such as ceramide. The stability of the vesicle dispersion solution was maintained without change in appearance and viscosity even after long-term storage at high temperature for eight weeks.
Keywords
Ceramide; Phospholipid; Edge activator; Solubilizer; Vesicle;
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