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http://dx.doi.org/10.14478/ace.2020.1062

Preparation of Hydrated Liquid Crystalline Vesicle Using Mutual Self-Association between Ceramide and Phospholipid  

Park, Min Seon (Division of chemistry and cosmetics, Dongduk Women's University)
Choi, Jeong Won (Division of chemistry and cosmetics, Dongduk Women's University)
Lee, Seol-Hoon (Division of chemistry and cosmetics, Dongduk Women's University)
Jin, Byung Suk (Division of chemistry and cosmetics, Dongduk Women's University)
Publication Information
Applied Chemistry for Engineering / v.31, no.5, 2020 , pp. 545-551 More about this Journal
Abstract
An attempt was made to prepare hydrated liquid crystalline vesicles by utilizing a mutual self-assembly between phospholipid and ceramide. When an edge activator was added to the mixture of phospholipid and ceramide, it was possible to prepare a vesicle containing a high content of poorly soluble ceramide. In this study, we investigated changes in structural and thermal behaviors of the hydrated liquid crystalline phase according to the mixed composition between phospholipid, ceramide, and sodium deoxycholate. Also, both the droplet size of the vesicles with different composition and stability of the vesicle dispersion solution were observed. From results of the experiments, by increasing the ratio of ceramide up to 70% in the mixture between phospholipid and ceramide, a formulation containing 3.5 wt% of ceramide in the vesicle dispersion solution could be obtained.
Keywords
Ceramide; Phospholipid; Sodium deoxycholate; Vesicle; Stability;
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Times Cited By KSCI : 4  (Citation Analysis)
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