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http://dx.doi.org/10.14478/ace.2019.1014

Practical Synthesis of N-Hydroxysuccinimide Using Lewis Acid Catalyst  

Kim, Dong Nyeon (Department of Applied Chemistry, Kookmin University)
Kim, Seok Chan (Department of Applied Chemistry, Kookmin University)
Publication Information
Applied Chemistry for Engineering / v.30, no.3, 2019 , pp. 313-315 More about this Journal
Abstract
A new synthetic method for N-hydroxysuccinimide (NHS), which is widely used in fine chemical and cosmetic industries, was developed. In a conventional synthesis, NHS is obtained by reacting $NH_2OH$ with succinic anhydride in a yield of about 70% using strong acid as a catalyst, which has an advantage of obtaining NHS relatively easily. However, it is expensive because of using a high cost succinic anhydride. In order to overcome this issue, we developed a new synthetic method for NHS with a moderate yield of 80% using a low cost succinic acid instead of succinic anhydride, alongside a stable Lewis acid catalyst, Zn acetate. As a result of the economic evaluation, it was confirmed that the cost reduction effect was about 15%.
Keywords
Activating reagent; N-Hydroxysuccinimide; Hydroxylamine ($NH_2OH$); Succinic acid; Lewis acid;
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