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http://dx.doi.org/10.14478/ace.2016.1035

Effect of Amine Oxide Zwitterionic Surfactant on Characteristics of Liposome  

Mo, DaHee (Dept. of Chemical and Biochemical Engineering, Dongguk University-Seoul)
Lee, SuMin (Dept. of Chemical and Biochemical Engineering, Dongguk University-Seoul)
Lee, JuYeon (Dept. of Chemical and Biochemical Engineering, Dongguk University-Seoul)
Han, DongSung (AK Central Research Center)
Lim, JongChoo (Dept. of Chemical and Biochemical Engineering, Dongguk University-Seoul)
Publication Information
Applied Chemistry for Engineering / v.27, no.3, 2016 , pp. 291-298 More about this Journal
Abstract
In this study, zwitterionic surfactants were added to liposome systems at different pH conditions to understand the effect of surfactants on liposome characteristics. For this purpose, amine oxide surfactants having different hydrocarbon chain lengths were synthesized and the structure of the resulting product was elucidated by using $^1H$ NMR, $^{13}C$ NMR, and FT-IR. In addition, the physical properties of newly synthesized surfactants such as critical micelle concentration (CMC), surface tension and isoelectric point were measured. The stability characteristics of liposome systems including average particle sizes and zeta potentials were measured by varying pH and hydrocarbon chain lengths of an amine oxide surfactant. Effects of the pH and hydrocarbon chain length of an amine oxide surfactant on fluidity of a liposome membrane were also examined by measuring the deformability and the binding degree between the surfactant and liposome.
Keywords
amine oxide zwitterionic surfactant; liposome; deformability; stability;
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Times Cited By KSCI : 13  (Citation Analysis)
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