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http://dx.doi.org/10.14478/ace.2015.1002

Characteristics and Cellular Protective Effects against UVA of Cationic Liposome Loaded with Quercetin and Rutin  

Gu, Hyun A (A Department of Fine Chemistry, Cosemetic R&D Center, Seoul National University of Science and Technology)
Kim, Moon Jin (A Department of Fine Chemistry, Cosemetic R&D Center, Seoul National University of Science and Technology)
Kim, Hae Soo (A Department of Fine Chemistry, Cosemetic R&D Center, Seoul National University of Science and Technology)
Ha, Ji Hoon (A Department of Fine Chemistry, Cosemetic R&D Center, Seoul National University of Science and Technology)
Yu, Eun Ryung (A Department of Fine Chemistry, Cosemetic R&D Center, Seoul National University of Science and Technology)
Park, Soo Nam (A Department of Fine Chemistry, Cosemetic R&D Center, Seoul National University of Science and Technology)
Publication Information
Applied Chemistry for Engineering / v.26, no.2, 2015 , pp. 165-172 More about this Journal
Abstract
Quercetin and its glycoside, rutin, are flavonoids, which are well known as natural antioxidants. In this study, cationic liposomes loaded with flavonoids (quercetin or rutin) were investigated for their effects on cell and skin permeability, and protective effects against UVA. The particle size of the empty cationic liposomes was in the range of 100~130 nm, and the zeta potential was + 33.05 mV. The entrapment efficiency of 0.5R/CL was higher than that of 0.5 Q/CL. The cellular uptake of the cationic liposomes was five-fold higher than that of liposomes. The skin permeability of quercetin and rutin was investigated using Franz diffusion cells. Compared to the initial loading dose, the amount of quercetin or rutin delivered to the skin by cationic liposomes was higher than that delivered by conventional liposomes or phosphate-buffered saline. From the protective effect of cationic liposomes against UVA ($25J/cm^2$), we found that the cell viability in cationic liposomes containing flavonoids was higher than that of using UVA irradiation only. These results indicate that cationic liposomes provide enhanced delivery of flavonoids (quercetin and rutin) into the skin and may be used for antiaging and antioxidant cosmetics.
Keywords
cationic liposome; quercetin; rutin; antioxidant; skin permeation;
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