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http://dx.doi.org/10.14478/ace.2013.1090

Characterization and Transdermal Delivery of Ethosomes Loaded with Eucommia ulmoides Extract  

Gu, Hyun A (Department of Fine Chemistry, Nanobiocosmetic Laboratory and Cosmetic R&D Center, Seoul National University of Science and Technology)
Kim, Hae Soo (Department of Fine Chemistry, Nanobiocosmetic Laboratory and Cosmetic R&D Center, Seoul National University of Science and Technology)
Kim, Moon Jin (Department of Fine Chemistry, Nanobiocosmetic Laboratory and Cosmetic R&D Center, Seoul National University of Science and Technology)
Yu, Eun Ryeong (Department of Fine Chemistry, Nanobiocosmetic Laboratory and Cosmetic R&D Center, Seoul National University of Science and Technology)
Joe, Gijung (Somang Cosmetics Co., Ltd.)
Jang, Jindong (Somang Cosmetics Co., Ltd.)
Kim, Bohyeon (Somang Cosmetics Co., Ltd.)
Park, Soo Nam (Department of Fine Chemistry, Nanobiocosmetic Laboratory and Cosmetic R&D Center, Seoul National University of Science and Technology)
Publication Information
Applied Chemistry for Engineering / v.24, no.6, 2013 , pp. 639-644 More about this Journal
Abstract
In this study, ethosomes loaded with Eucommia ulmoides extracts that have anti-inflammatory and anti-aging activities on the skin were prepared as cosmetic materials. The particle size, physical property, and entrapment efficiency of ethosomes to identify their stabilities during 4 weeks were measured. Ethosomes containing 0.01~0.05% E. ulmoides extracts did not show either precipitation or separation. The mean particle size of these ethosomes was 136.4 nm, and monodisperse. The particle size of ethosome containing 0.05% E. ulmoides extracts was 151.15 nm and the entrapment efficiency was 81.79%. Therefore, in vitro skin permeation experiment was performed with ethosome containing 0.05% E. ulmoides extracts that showed the high loading efficiency and stability during 4 weeks. The order of skin permeation of E. ulmoides extracts was ethosome (77.16%) > liposome (62.80%) > ethanolic solutoin (41.59%). These results suggest that ethosomes containing 0.05% E. ulmoides extracts are effective for the skin permeation and may be used as a cosmetic formulation containing plant extracts.
Keywords
Eucommia ulmoides Oliver; ethosome; transdermal; cosmetic materials;
Citations & Related Records
Times Cited By KSCI : 6  (Citation Analysis)
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