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http://dx.doi.org/10.14478/ace.2013.24.5.471

The Preparation and Release Property of Alginate Microspheres Coated Gelatin-cinnamic Acid  

Lee, Ju Hyup (College of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University)
Ma, Jin Yeul (Center for Herbal Medicine Improvement Research, Korea Institute of Oriental Medicine)
Kim, Jin-Chul (College of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University)
Publication Information
Applied Chemistry for Engineering / v.24, no.5, 2013 , pp. 471-475 More about this Journal
Abstract
This study is about photosensitive microspheres prepared by coating alginate microspheres with gelatin-cinnamic acid conjugate. Firstly, alginate microspheres was prepared in water-in-oil (W/O) emulsion and then they were coated with gelatin- cinnamic acid conjugate. Herein, gelatin-cinnamic acid conjugate is obtained by the amidation between an amine group of gelatin and a carboxy group of cinnamic acid. Cinnamic acid is widely used as a photo-responsive material easy to dimerize and dedimeriz under UV irradiation at ${\lambda}$ = 254 nm and ${\lambda}$ = 365 nm, respectively. As shown in SEM-EDS, alginate was successfully coated with gelatin-ciannmic acid. By determining the absorbance of coated microspheres at 270nm, the amount of cinnamic acid per microspheres was 0.13/1. The SEM photos showed the size of coated microspheres is around $10{\mu}m$. And the degrees of dimerization and dedimerization were calculated to be 49% and 23% respectively. Then the release of FITC-dextran from the coated micrspheres was studied and release the degree was 42%. As a result, the coated microspheres have potential to be used as a photo-responsive drug carrier to delivery drugs.
Keywords
alginate microspheres; gelatin; Cinnamic acid; photo sensitivity;
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