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Optimization of Synthesis Condition of Monolithic Sorbent Using Response Surface Methodology  

Park, Ha Eun (Department of Chemical Engineering, Inha University)
Row, Kyung Ho (Department of Chemical Engineering, Inha University)
Publication Information
Applied Chemistry for Engineering / v.24, no.3, 2013 , pp. 299-304 More about this Journal
Abstract
A 17-run Box-Behnken design was used to optimize the synthesis conditions of a monolithic sorbent. The effects of the amount of monomer (mL), crosslink (mL) and porogen (mL) were investigated. The experimental data were fitted to a second-order polynomial equation by the multiple regression analysis and examined using statistical methods. The adjusted coefficient of determination ($R^2$) of the model was 0.9915. The probability value (p < 0.0001) demonstrated a high significance for the regression model. A mean amount of polymer as 2120.15 mg was produced under the following optimum synthesis conditions: the optimized volumes of monomer, crosslink and porogen are 0.30, 1.40, and 1.47 mL, respectively. This was in good agreement with the predicted model value.
Keywords
Box-Behnken design; monolithic sorbent; synthesis; response surface methodology;
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