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Ethosome Formulation for Enhanced Transdermal Delivery of Artemisia princeps Pampanini Extracts  

Yang, Hyun Gab (Department of Fine Chemistry, Nanobiocosmetic Laboratory and Cosmetic R&D Center, Seoul National University of Science and Technology)
Kim, Hye Jin (Department of Fine Chemistry, Nanobiocosmetic Laboratory and Cosmetic R&D Center, Seoul National University of Science and Technology)
Kim, Hae Soo (Department of Fine Chemistry, Nanobiocosmetic Laboratory and Cosmetic R&D Center, Seoul National University of Science and Technology)
Park, Soo Nam (Department of Fine Chemistry, Nanobiocosmetic Laboratory and Cosmetic R&D Center, Seoul National University of Science and Technology)
Publication Information
Applied Chemistry for Engineering / v.24, no.2, 2013 , pp. 190-195 More about this Journal
Abstract
In our previous studies, the antioxidant, anti-aging, and antibacterial activities of Artemisia princeps Pampnini (A. princeps Pamp.) extract were reported. In this study, ethosome formulations for the enhanced transdermal delivery of A. princeps Pamp. extract were prepared. The particle size, loading efficiency and skin permeation of them were evaluated. The ethosome loaded with 0.06% ethyl acetate fraction of A. princeps Pamp. extract was more stable and maintained the constant particle size for 3 weeks after being prepared. The particle size of ethosome containing 0.06% ethyl acetate fraction was $287.05{\pm}0.25nm$ and the loading efficiency was $51.96{\pm}0.01%$. The ethosome formulation exhibited the greater enhancement of skin permeation than of general liposome and 20% ethanol solution in skin permeability experiments.
Keywords
ethosomes; Artemisia princeps Pampanini; skin permeation studies; cosmetics;
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