Browse > Article

Preparation of Nano-emulsion Containing Polygonum aviculare Extract for Enhanced Transdermal Delivery  

Lim, Myoung Sun (Department of Fine Chemistry, Cosmetic R&D Center, Seoul National University of Science and Technology)
Park, Min A (Department of Fine Chemistry, Cosmetic R&D Center, Seoul National University of Science and Technology)
Park, Soo Nam (Department of Fine Chemistry, Cosmetic R&D Center, Seoul National University of Science and Technology)
Publication Information
Applied Chemistry for Engineering / v.23, no.2, 2012 , pp. 222-227 More about this Journal
Abstract
In this study, nano-emulsion containing ethyl acetate fraction of Polygonum aviculare (P. aviculare) extract was prepared and skin permeability of the nano-emulsion was evaluated. Nano-emulsion was prepared using homogenizer and microfluidizer by the high-energy method. The droplet size and loading efficiency of nano-emulsion containing ethyl acetate fraction of P. aviculare extract were determined. The mean droplet size was 238 nm and the loading efficiency was more than 98%. The size distribution of nano-emulsion was a monodispersed form and nano-emulsion was more stable than that of using typical emulsion without using the microfluidizer. The in vitro skin permeation study of nano-emulsion containing ethyl acetate fraction of P. aviculare extract was carried out using Franz diffusion cells. Compared to 1,3-butylene glycol, nano-emulsion showed greater values of cumulative permeation of ethyl acetate fraction from P. aviculare extract. These results indicate that the stability and skin permeability of nano-emulsion containing ethyl acetate fraction of P. aviculare exerting anti-oxidative and anti-aging activities were enhanced.
Keywords
Polygonum aviculare; flavonoids; nano-emulsion; transdermal delivery; Franz diffusion cell;
Citations & Related Records
연도 인용수 순위
  • Reference
1 K. Y. Kyoung, U. K. Jee, and W. G. Cho, J. Kor. Pharm. Sci., 37, 85 (2007)
2 H. S. Kang, S. S, Kwon, B. H. Kim, B. R. Lee, K. H. Kang, J. E. Hong, S. H. Han, and I. S. Chang, J. Ind. Eng. Chem., 8, 348 (2002).
3 W. G. Cho, J. Soc. Comet. Scientist, Korea., 37, 1 (2011).
4 B. R. Won. M. K. Kang, and S. N. Park, J. Soc. Comet. Scientist, Korea., 35, 79 (2009).
5 L. Houillot, J. Nicolas, M. Save, and B. Charleus, Langmuir, 21, 6726 (2005).   DOI   ScienceOn
6 A. Musyanovych, V. Mailander, and K. Landfester, Biomacromolecules, 6, 1824 (2005).   DOI   ScienceOn
7 W. Seifriz, Science, 87, 212 (1938).   DOI   ScienceOn
8 M. Cajkovac, L. Oremovic, and V. Cajkovac, Pharmazie, 47, 39 (1992).
9 M. Sznitowska, K. Zurowska-Pryczkowska, S. Janicki, and T. Jarvinen, Int. J. Pharm., 184, 115 (1999).   DOI   ScienceOn
10 P. F. Yue, H. L. Yuan, W. F. Zhu, L. B. Cong, H. Xie, Z. G. Liu, L. J. Wang, and X. H. Xiao, Biol. Pharm. Bull., 31, 45 (2008).   DOI   ScienceOn
11 R. Barnadas-Rodriguez and M. Sabes, Int. J. Pharm., 213, 175 (2001).   DOI   ScienceOn
12 A. Towata, M. Sivakumar, K. Yasui, T. Tuziuti, T. Kozuka, and Y. Lida, Ultrason Sonochem, 14, 705 (2007).   DOI   ScienceOn
13 C. Solans, J. Esquena, A. Forgiarini, D. Morales, N. Uso'n, and P. Izquierdo, Nano emulsions: formation and properties: surfactants in solution: fundamentals and applications, Surfactant Science Series, eds. D. Shah, B. Moudgil, K. L. Mittal, Marcel Dekker, New York, 525 (2002).
14 P. Izquierdo, J. Feng, J. Esquena, T. F. Tadros, J. C. Dederen, M. J. Garcia, M. Azemar, and C. Solans, J. Colloid Interface Sci., 285, 388 (2005).   DOI   ScienceOn
15 J. B. Tagne, S. Kakumanu, and R. J. Nicolosi, Mol. Pharm., 5, 1055 (2008).   DOI   ScienceOn
16 S. B. Calderilla-Fajardo, J. Cazares-Delgadillo, R. Villalobos-Garcia, D. Quintanar-Guerrero, A. Ganem- Quintanar, and R. Robles, Drug Dev. Ind. Pharm., 32, 107 (2006).   DOI   ScienceOn
17 E. D. Sudol and M. S. El-Aasser, In emulsion polymerization and emulsion polymers, P. A. Lovell and M. S. El-Aasser, Eds., John Wiley & Sons, Ltd., Chichester, United Kingdom, 700 (1997).
18 L. Marszall, In nonionic surfactants: surfactant science series, ed. M. J. Shick, Marcel Dekker, New York, 23, 493 (1987).
19 K. Shinoda and H. J. Saito, Colloid Interface Sci., 26, 70 (1968).   DOI   ScienceOn
20 F. Q. Xu, H. B. Liu, J. G. Luo, J. L. Zhang, and H. S. Guan, Periodical of Ocean University of China, 3 (2010)
21 F. Q. Xu, H. S. Guan, G. Q. Li, and H. B. Liu, Chromatograpia, 69, 1251 (2009).   DOI   ScienceOn
22 C. Y. Hsu, Biol Res., 39, 281 (2006).
23 H. S. Kim, Kor. J. Mycol., 8, 1 (1980).
24 S. N. Park, S. Y. Kim, M. J. Kim, G. N. Lim, M. S. Lim, H. J. Lee, M. A. Park, and J. E. Kim, Cellular Protective Effect of Polygonum aviculare Extract and Preparation of Liposome Containing It, IFSCC conference, Bangkok, (2011).
25 W. G. Cho, J. Korean Oil Chemists' Soc., 24, 410 (2007).
26 S. S. Baik. J. Soc. Comet. Scientist Korea., 19, 127 (1993).