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http://dx.doi.org/10.14478/ace.2011.22.6.599

The Efficacy of β-cyclodextrin/polyethyleneimine/silk Fibroin Hydrogel in Healing Burnt Wound  

Seo, Seung Ree (Division of Biotechnology & Bioengineering and Institute of Bioscience and Biotechnology, Kangwon National University)
Lee, Mi Sun (Division of Biotechnology & Bioengineering and Institute of Bioscience and Biotechnology, Kangwon National University)
Kim, Jin-Chul (Division of Biotechnology & Bioengineering and Institute of Bioscience and Biotechnology, Kangwon National University)
Publication Information
Applied Chemistry for Engineering / v.22, no.6, 2011 , pp. 599-604 More about this Journal
Abstract
In this study, we investigated the efficacy of ${\beta}$-cyclodextrin (${\beta}CD$) hydrorogel containing silk fibroin (SF) on healing burnt wound. Tosyl ${\beta}CD$ was conjugated to polyethyleneimine (PEI) using epichlorohydrin (EPI) as a cross-linker. The ${\beta}CD/PEI/SF$ hydrogel was applied on the back of mouse and then the efficacy of hydrogel was compared with both positive control group and negative control group. There was no wound healing efficacy showed neither in the drug loaded ${\beta}CD/PEI/SF$ hydrogel group nor in the drug unloaded ${\beta}CD/PEI/SF$ hydrogel group. On the other hand, in the positive control group, a significant reduction of the wound size after the usage of OTC hydrorogel was obtained. The burn-healing histological result showed a similar phenomenon. After hematoxylin-eosin staining the skin induced by burning, and the epithelial growth observed in the dermis, the efficacy of ${\beta}CD/PEI/SF$ hydrogel in healing burnt wound could not be clearly identified.
Keywords
${\beta}$-cyclodextrin; silk fibroin; burn; hydrogel; wound healing;
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1 Y. H. Choi, M. G. Kim, D. H. Ahn, S. J. Cho, S. H. Hong, J. Y. Lee, J. W. Lee, and H. S. Kim, J. Korean Surg. Soc., 79, 1 (2010).   DOI   ScienceOn
2 A. K. Azad, N. Sermsintham, S. Chandrkrachang, and W. f. Stevens, J. Biomed. Mater. Res. B., 69, 216 (2004).
3 Y. C. Kim, J. C. Shin, and Y. S. Kim, Yonsei Med J., 37, 181 (1996).   DOI
4 I. Ono, H. Gunji, J. Z. Zhang, K. Maruyama, and F. Kaneko, Burns., 5, 352 (1995).
5 D. M. Simpson and R. Ross, J. Clin. Invest., 51, 2009 (1972).   DOI   ScienceOn
6 Y. Y. Liu, X. D. Fan, H. Hu, and Z. H. Tang, Macromol Biosci., 4, 729 (2004).   DOI   ScienceOn
7 W. H. Park, L. Jeong, D. I. Yoo, and S. Hudson, Polymer., 45, 7151 (2004).   DOI   ScienceOn
8 K. E. Park, S. Y. Jung, S. J. Lee, B. M. Min, and W. H. Park, Int. J. Biol. Macromol., 38, 165 (2006).   DOI   ScienceOn
9 X. Yang and J. C. Kim, Int. J. Biol. Macromol., 48, 661 (2011).   DOI   ScienceOn
10 S. W. Kim, Y. H. Bae, and T. Okano, Pharm Res., 9, 283 (1992).   DOI   ScienceOn
11 C. S. Sobral, A. Gragnani, J. Morgan, and L. M. Ferreira, Burns., 33, 613 (2007).   DOI   ScienceOn
12 T. C. Allen, Laboratory methods in histotechnology. E. B. Prophet, B. Mills, J. B. Ariington, L. H. Sobin, 1, 53, Armed Forces Institute of Pathology, Washington DC, (1992).
13 B. C. Kang, J. S. Nam, J. H. Che, S. M. Lee, J. M. Yang, H. M. Lee, J. H. Park, D. H. Song, S. H. Yoo, and Y. S. Lee, Korean J. Toxicol., 13, 149 (1997).
14 S. E. Bae, T. K. Oh, and S. C. Park, Korean J. Toxicol., 13, 161 (1997).
15 Y. M. Sun, C. C. Chang, W. F. Huang, and H. C. Liang, J. Control Release., 47, 247 (1997).   DOI   ScienceOn