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Preparation and Characterization of Ethosome Containing Hydrophobic Flavonoid Luteolin  

Lee, Sang Min (Nabion Corporation)
Choi, Moon Jae (Department of Chemical Engineering, Hanyang University)
Lee, Young Moo (Department of Chemical Engineering, Hanyang University)
Jin, Byung Suk (Department of Applied Chemistry, Dongduk Women's University)
Publication Information
Applied Chemistry for Engineering / v.21, no.1, 2010 , pp. 40-45 More about this Journal
Abstract
Entrapment of hydrophobic flavonoid luteolin into ethosome was carried out for improving its stability and making practical application in the field of drug and cosmetics. The formation of liquid crystalline phase and its thermal properties were investigated by polarized optical microscopy and DSC. The phase inversion from W/O to W/O/W was detected by conductivity change with the addition of PBS buffer solution into the ethanol-dissolved lecithin mixture. The particle size change of ethosome with constituent composition was examined, which showed that the incorporation of luteolin into lecithin up to 10% had little effect on the size of ethosome. Enhancement of stability of luteolin by entrapment into ethosome was verified through DPPH test. The stabilization efficacy of ethosome was improved further by the addition of tocopherol.
Keywords
ethosome; hydrophobic; luteolin; stability; liquid crystalline phase;
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