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Trends in the Studies of Glucose-Responsive Drug Delivery Systems  

Jo, Seong-Min (Department of Biomaterials Engineering, Kangwon National University)
Kim, Jin-Chul (Department of Biomaterials Engineering, Kangwon National University)
Publication Information
Applied Chemistry for Engineering / v.20, no.6, 2009 , pp. 581-585 More about this Journal
Abstract
Diabetes is caused by the lack of insulin secretion or the reduction in its sensitivity. The recent treatments for diabetes do not fulfill the requirements for the maintaining of normal blood glucose level. The most frequently used treatment for type I diabetes is an insulin injection. However, the insulin injection often involves the life-threatening risk and the low compliance of patients. Accordingly, extensive studies have been done to overcome the shortcomings of the injection. A representative approach is to employ self-regulated insulin delivery systems. This report includes the principles of glucose-responsive release in the self-regulated insulin delivery systems.
Keywords
self-regulated insulin delivery; glucose-responsive release; concanavalin A; glucose oxidase; phenylboronic acid;
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