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Study on the Immobilized Lipase-Mediated Selective Synthesis of 1,3-Diglyceride  

Chung, Dae-won (Department of Polymer Engineering, College of Engineering, Suwon University)
Cho, Mi Hye (Department of Polymer Engineering, College of Engineering, Suwon University)
Publication Information
Applied Chemistry for Engineering / v.20, no.4, 2009 , pp. 443-448 More about this Journal
Abstract
It is known that 1,3-diglyceride (1,3-DG) hardly accumulates inside human body because the metabolism of 1,3-DG is entirely different from that of general fats such as triglycerides (TG). This research focuses on the selective synthesis of 1,3-DG by the esterification reaction using an immobilized lipase. For a reaction between glycerin and oleic acid (OA) with a mole ratio of 1 : 2 under vacuum, changes in the compositions of monoglyceride (MG), TG and DG and the contents of 1,3-isomers in DG were investigated, as a function of reaction temperature and the amount of lipase. The reactivities determined by the rate of the consumption of OA became higher with increased in temperature and the amount of lipase. Changes in the compositions of MG, DG and TG, however, occurred after the DG content reached maximum, which were found to be dependent on various factors. TG was a main product, and significant decrease in the amount of both 1,3-DG and DG were observed, when reactions were carried out at high temperatures or when 10 wt% of lipase was used.
Keywords
1,3-diglyceride; lipase; esterification; oleic acid; selective synthesis;
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