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Construction of Antibacterial Electrospun Nanofiber from Poly(styrene-co-sulfadiazine) via Electrospinning  

Hwang, Seok-Ho (Green Chemistry & Engineering R&D Department, Korea Institute of Industrial Technology)
Ahn, Kyung-Hwan (Green Chemistry & Engineering R&D Department, Korea Institute of Industrial Technology)
Cha, Heechul (Gyeonggi Technology Service Division, Korea Institute of Industrial Technology)
Kim, Jeong-Yeol (Green Chemistry & Engineering R&D Department, Korea Institute of Industrial Technology)
Hwang, Hong-Gu (Department of Chemical & Environmental Engineering, Soongsil University)
Huh, Wansoo (Department of Chemical & Environmental Engineering, Soongsil University)
Lee, Sangwon (Department of Chemical & Environmental Engineering, Soongsil University)
Publication Information
Applied Chemistry for Engineering / v.20, no.4, 2009 , pp. 386-390 More about this Journal
Abstract
In this study, sulfadiazine acrylamide monomer was synthesized by the reaction of sulfadiazine, known as an antibiotic substance, with acryloyl chloride. The monomer was characterized by $^1H-NMR$, and $^{13}C-NMR$. Using the synthesized sulfadiazine acrylamide monomer and styrene monomer, a copolymer, poly(styrene-co-sulfadiazine), was obtained by the free radical copolymerization and characterized by $^1H-NMR$, GPC, DSC and TGA. The copolymer nanofibers web has been successfully prepared by electrospinning technique under DMF solution. The diameter of the nanofibers was in the range between 500 and 800 nm. Antibacterial activity of the nanofiber web was evaluated utilizing the colony counting method against Staphylococcus aureus and Escherichia coli.
Keywords
poly(styrene-co-sulfadiazine); electrospinning; antibiotics; nanofiber; sulfadiazine;
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