Browse > Article

Variation of Characteristics of Nonstoichiometric Apatite Induced by Sodium Salt  

Jung, Jae-Young (Laboratory of Biointerfaces & Tissue Engineering Research, Department of Chemical Engineering, Institute of Tissue Regeneration Engineering, Dankook University)
Han, Juyun (Laboratory of Biointerfaces & Tissue Engineering Research, Department of Chemical Engineering, Institute of Tissue Regeneration Engineering, Dankook University)
Choi, Sun-Mi (Laboratory of Biointerfaces & Tissue Engineering Research, Department of Chemical Engineering, Institute of Tissue Regeneration Engineering, Dankook University)
Lee, Woo-Kul (Laboratory of Biointerfaces & Tissue Engineering Research, Department of Chemical Engineering, Institute of Tissue Regeneration Engineering, Dankook University)
Publication Information
Applied Chemistry for Engineering / v.19, no.3, 2008 , pp. 326-331 More about this Journal
Abstract
The purpose of this work is to develope sodium-containing nonstoichiometric apatitic coatings on solid substrate. The apatitic coatings prepared at different concentrations of sodium salt indicated that the presence of sodium ions exerted significant effects on the physicochemical properties of the apatitic coating including surface morphology, chemical state, and Ca/P ratio. The variation of these properties was sustained up to 0.01 mM of sodium ion concentration. The ratio of calcium to phosphorus was varied from 2.18 to 2.03 which indicated the apatitic coating prepared in this study was calcium-rich nonstoichiometric apatite. The structure of all the samples appeared to be low crystalline. In the presence of sodium ion within the apaptitic coating, the adhesion of human osteoblast-like SaOS-2 cells was significantly promoted. On the other hand, the proliferation of the cells on the apatitic coatings was decreased with the increase of sodium ions. This reverse response of SaOS-2 cells indicates that the interaction between SaOS-2 and apatitic surface triggered considerable changes in intracellular mechanisms including cellular signal transductions.
Keywords
nonstoichimetric apatite; sodium; osteoblast; SEM; XRD; EDX;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By SCOPUS : 0
연도 인용수 순위
1 M. Fini, A. Cigada, G. Rondelli, R. Chiesa, R. Giardino, G. Giavaresi, N. N. Aldini, P. Torricelli, and B. Vicentini, Biomaterials, 20, 1587 (1999)   DOI   ScienceOn
2 J.-Y. Jung and W.-K. Lee, J. Adv. Sci. Technol., 2, 17 (2006)
3 O. Grabmann and R. B. Heimann, J. Biomed. Mater. Res. (Appl. Biomater.), 53, 685 (2000)   DOI   ScienceOn
4 P. Taddei, A. Tinti, G. Bottura, and A. Bertoluzza, Biopolymers(Biospectroscopy), 57, 140 (2000)
5 K. Gotfredsen, A. Wennerberg, C. Johansson, L. T. Skovgaard, and E. Hjorting-Hansen, J. Biomed. Mater. Res., 29, 1223 (1995)   DOI   ScienceOn
6 S. W. K. Kweh, K. A. Khor, and P. Cheang, Biomaterials, 23, 775 (2002)   DOI   ScienceOn
7 J. L. Arias, F. J. Garcia-Sanz, M. B. Mayor, S. Chiussi, J. Pou, B. Leon, and M. Perez-Amor, Biomaterials, 19, 883 (1998)   DOI   ScienceOn
8 V. R. Zhelyaskov, S. Liu, and M. P. Broderick, Kid. Int., 57, 1764 (2000)   DOI   ScienceOn
9 S. Ozawa and S. Kasugai, Biomaterials, 17, 23 (1996)   DOI   ScienceOn
10 M. J. Mo, H. Y. Shin, I. H. Jung, J. S. Ko, J. McGuire, and W. K. Lee, J. Ind. Eng. Chem., 11, 261 (2005)
11 S. J. Gadaleta, E. P. Paschalis, F. Betts, R. Mendelsohn, and A. L. Boskey, Calcif. Tissue Int., 58, 9 (1996)   DOI
12 M. A. Logan, J. Biol. Chem., 110, 375 (1935)
13 S. A. Redey, M. Nardin, D. Bernache-Assolant, C. Rey, P. Delannoy, L. Sedel, and P. J. Marie, J. Biomed. Mater. Res., 50, 353 (2000)   DOI   ScienceOn
14 S. Ban and S. Maruno, Biomaterials 19, 1245 (1998)   DOI   ScienceOn