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Theoretical Consideration of the Modified Haldane Model of the Substrate Inhibition in the Microbial Growth Processes  

Hwang, Young-Bo (School of Material Science & Nano Chemical Engineering, Kunsan National University)
Publication Information
Applied Chemistry for Engineering / v.19, no.3, 2008 , pp. 277-286 More about this Journal
Abstract
This paper deals with the theoretical derivation of the modified Haldane model of the substrate inhibition in the microbial growth processes. Based on the biological concepts of substrate-receptor complex working mechanisms, a new microbial kinetics of N-fold multiplex substrate inhibition and its generalization has been considered theoretically, which is natural expansion of the simple substrate inhibition mechanism in the enzyme reaction. As a result, the modified Haldane model of the substrate inhibition turns out to be a well-designed four-parameter kinetic model with a biological constant of the total substrate inhibition concentration.
Keywords
N-fold multiplex substrate inhibition; modified Haldane model; total substrate inhibition concentration;
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