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Preparation and Characterization of EGCG Entrapped Ethosome  

Gwak, Hyo Jung (Department of Applied Chemistry, Dongduk Women's University)
Jin, Byung Suk (Department of Applied Chemistry, Dongduk Women's University)
Publication Information
Applied Chemistry for Engineering / v.18, no.2, 2007 , pp. 130-135 More about this Journal
Abstract
Entrapment of (-)-epigallocatechin gallate (EGCG) into ethosome was carried out for improving its stability against decomposition. Solubility of EGCG was increased by the addition of ethanol into water, which enable ethosome to entrap appropriate amount of EGCG. It was observed that the EGCG solution concentration and constituent lipid composition had a considerable effect on the particle size and entrapment efficiency of ethosomes. The formation of liquid crystalline phase in ethosome was investigated by polarized optical microscopy. By comparing the stability of EGCG in solution and in ethosome exposed to UV or high temperature, we evaluated the EGCG stabilization effect through its entrapment in ethosome. Incorporation of tocopherol into ethosome retarded the decomposition of EGCG under UV.
Keywords
ethosome; EGCG; stability; liquid crystalline phase; entrapment efficiency;
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