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Asymmetric Hydrogenation of Ethyl Pyruvate over Bimetallic Rh-Pt/Al2O3 Catalysts Modified with Dihydrocinchonidine  

Cho, Hong-Baek (Division of Material and Chemical Engineering, Hanyang University)
Kang, Joon-seok (Division of Material and Chemical Engineering, Hanyang University)
Park, Yeung-Ho (Division of Material and Chemical Engineering, Hanyang University)
Publication Information
Applied Chemistry for Engineering / v.17, no.4, 2006 , pp. 369-374 More about this Journal
Abstract
$Rh-Pt/Al_{2}O_{3}$ catalysts were used for the first time to study its reaction characteristics in the asymmetric hydrogenation of ethyl pyruvate. The catalysts were prepared either by impregnation of Rh on a commercial $Pt/Al_{2}O_{3}$ or by sequential impregnation of Rh followed by impregnation of Pt on $Al_{2}O_{3}$. Reaction rate and enantiomeric excess (ee%) were compared according to the preparation method, Rh contents, and the reduction temperature of the catalyst. The physical characteristics of the catalysts were analyzed using XRD and TEM. Bimetallic $Rh-Pt/Al_{2}O_{3}$ catalysts showed an improved reaction rate and optical purity (63.6 ee%) with increasing the reduction temperature. The variation of the Rh contents as well as the preparation method elicited a big difference on the reaction rate, while enantiomeric excess (ee%) was lower (56~60%) with all bimetallic catalysts than with monometallic $Pt/Al_{2}O_{3}$ catalyst.
Keywords
$Rh-Pt/Al_{2}O_{3}$; bimetallic catalyst; asymmetric hydrogenation; ethyl pyruvate; sequential impregnation;
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