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Preparation and Characterizatino of Nano-sized Liposome Containing Proteins Derived from Coptidis rhizoma  

Oh, Seng Ryong (Korea Institute of Industrial Technology)
Lee, Sang Bong (Korea Institute of Industrial Technology)
Cho, Kye Min (Korea Institute of Industrial Technology)
Choi, Moon Jae (Nabion Corporation)
Jin, Byung Suk (Department of Applied Chemistry, Dongduk Women's University)
Han, Yong Moon (College of Pharmacy, Dongduk Women's University)
Lee, Young Moo (School of Chemical Engineering, College of Engineering, Hanyang University)
Shim, Jin Kie (Korea Institute of Industrial Technology)
Publication Information
Applied Chemistry for Engineering / v.17, no.1, 2006 , pp. 52-57 More about this Journal
Abstract
Coptidis Rhizoma, an antimicrobial agent from natural source, is known to have the antiviral effect on the Candida albicans that causes the infectious dermatitis. The valuable protein was extracted from the Coptidis Rhizoma, To prevent denaturalization from external stimulus and improve adsorption onto the skin, the nano-sized liposomes were prepared as a carrier. The CPR-containing liposomes showed an average diameter of 187 nm, surface charge of 3.337 mV and 33% encapsulation efficiency. The release behavior of CRP from the liposome was investigated with various temperature and releasing time. The PVA solution was coated on the surface of liposome to improve the stability. The coated liposome showed slow release behavior in comparison with the non-coated liposome. The CRP in the liposome maintained the effect on the Candida albicans after treating it at 50 and with ultraviolet for 24 h.
Keywords
coptidis rhizoma; candida albicans; liposome; surface coating;
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