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http://dx.doi.org/10.7776/ASK.2022.41.5.564

Recent clinical trials with ultrasound induced blood-brain barrier opening  

Park, Juyoung (College of Future Industry, Department of High-tech Medical Device, Gachon University)
Publication Information
The Journal of the Acoustical Society of Korea / v.41, no.5, 2022 , pp. 564-569 More about this Journal
Abstract
Blood-Brain Barrier (BBB) is the brain protecting system blocking the inflow of harmful substances into brain parenchyma from brain blood vessel. However, the BBB has a negative effect on the treatment of various brain diseases such as Alzheimer's dementia or brain tumors because it also prevents drug delivery into brain parenchyma. To overcome this problem, a brain drug delivery technique using Focused Ultrasound (FUS) which allows BBB to be temporarily opened by inducing the acoustic cavitation effect of microbubbles has been developed. Thus far, various studies using the FUS technique has been conducted to improve drug delivery efficiency, and therefore, this paper discusses recently developed drug delivery technologies using the FUS-induced BBB opening.
Keywords
Blood-Brain Barrier (BBB); Brain drug delivery; Acoustic cavitation; Focused Ultrasound;
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Times Cited By KSCI : 3  (Citation Analysis)
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