Browse > Article
http://dx.doi.org/10.7776/ASK.2020.39.1.016

High-intensity focused ultrasound beam path visualization using ultrasound imaging  

Song, Jae Hee (Queenland Brain Institute, University of Queenland)
Chang, Jin Ho (Departments of Electronic Engineering and Biomedical Engineering, Sogang University)
Yoo, Yang Mo (Departments of Electronic Engineering and Biomedical Engineering, Sogang University)
Publication Information
The Journal of the Acoustical Society of Korea / v.39, no.1, 2020 , pp. 16-23 More about this Journal
Abstract
In High-Intensity Focused Ultrasound (HIFU) treatment, effective localization of HIFU focus is important for developing a safe treatment plan. While Magnetic Resonance Imaging guided HIFU (MRIgHIFU) can visualize the ultrasound path during the treatment for localizing HIFU focus, it is challenging in ultrasound imaging guided HIFU (USIgHIFU). In the present study, a real-time ultrasound beam visualization technique capable of localizing HIFU focus is presented for USIgHIFU. In the proposed method, a short pulse, with the same center frequency of an imaging ultrasound transducer below the regulated acoustic intensity (i.e., Ispta < 720 mW/㎠), was transmitted through a HIFU transducer whereupon backscattered signals were received by the imaging transducer. To visualize the HIFU beam path, the backscattered signals underwent dynamic receive focusing and subsequent echo processing. From in vitro experiments with bovine serum albumin gel phantoms, the HIFU beam path was clearly depicted with low acoustic intensity (i.e., Ispta of 94.8 mW/㎠) and the HIFU focus was successfully localized before any damages were produced. This result indicates that the proposed ultrasound beam path visualization method can be used for localizing the HIFU focus in real time while minimizing unwanted tissue damage in USIgHIFU treatment.
Keywords
High-intensity focused ultrasound; Ultrasound image guidance; Focal point position; Ultrasound beam path;
Citations & Related Records
연도 인용수 순위
  • Reference
1 E. E. Konofagou, J. Thierman, T. Karjalainen, and K. Hynynen, "The temperature dependence of ultrasoundstimulated acoustic emission," Ultrasound Med. Biol. 28, 331-338 2002).   DOI
2 R. Seip and E. S. Ebbini, "Noninvasive estimation of tissue temperature response to heating fields using diagnostic ultrasound," IEEE Trans. Biomed. Eng. 42, 828-839 (1995).   DOI
3 V. A. Khokhlova, S. M. Bobkova, and L. R. Gavrilov, "Focus splitting associated with propagation of focused ultrasound through the rib cage," Acoust. Phys. 56, 622-632 (2010).
4 F. Li, X. Gong, K. Hu, C. Li, and Z. Wanng, "Effect of ribs in HIFU beam path on formation of coagulative necrosis in goat liver," Proc. the 5th International Symposium on Therapeutic Ultrasound. Oxford, UK, 829, 447-480 (2006).
5 C. Lafon, V. Zderic, M. L. Nobel, J. C. Yuen, P. J. Kaczkowski, O. A. Sapozhnikov, F. Chavrier, L. A. Crum, and S. Vaezy, "Gel phantom for use in highintensity focused ultrasound dosimetry," Ultrasound Med. Biol. 31, 1383-1389 (2005).   DOI
6 B. A. Rabkin, V. Zderic, and S. Vaezy, "Hyperecho in ultrasound images of HIFU therapy: Involvement of cavitation," Ultrasound Med. Biol. 31, 947-956 (2005).   DOI
7 G. ter Haar, "Therapeutic ultrasound," Eur. J. Ultrasound, 9, 3-9 (1999).   DOI
8 G. ter Haar, "High intensity ultrasound," Surg. Innov. 8, 77-89 (2001).   DOI
9 J. E. Kennedy, "High-intensity focused ultrasound in the treatment of solid tumours," Nat. Rev. Cancer, 5, 321-327 (2005).   DOI
10 D. Arora, D. Cooley, T. Perry, M. Skliar, and R. B. Roemer, "Direct thermal dose control of constrained focused ultrasound treatments: phantom and in vivo evaluation," Phys. Med. Biol. 50, 1919-1935 (2005).   DOI
11 J. Seo, B. C. Tran, T. L. Hall, J. B. Fowlkes, G. B. Abrams, M. O'Donnell, and C. A. Cain, "Evaluation of ultrasound tissue damage based on changes in image echogenicity in canine kidney," IEEE Trans. Ultrason. Ferroelect. Freq. Contr. 52, 1111-1120 (2005).   DOI
12 S. Vaezy, X. Shi, R. W. Martin, E. Chi, P. I. Nelson, M. R. Bailey, and L. A. Crum, "Real-time visualization of high-intensity focused ultrasound treatment using ultrasound imaging," Ultrasound Med. Biol. 27, 33-42 (2001).   DOI
13 R. Catane, A. Beck, Y. Inbar, T. Rabin, N. Shabshin, S. Hengst, R. M. Pfeffer, A. Hanannel, O. Dogadkin, B. Liberman, and D. Kopelman, "MR-guided focused ultrasound surgery (MRgFUS) for the palliation of pain in patients with bone metastases - preliminary clinical experience," Ann. Oncol. 18, 163-167 (2007).   DOI
14 O. Esnault, B. Franc, J. P. Monteil, and J. Y. Chapelon, "High-intensity focused ultrasound for localized thyroidtissue ablation: Preliminary experimental animal study," Thyroid, 14, 102-1076 (2004).
15 H. Furusawa, K. Namba, H. Nakahara, C. Tanaka, Y. Yasuda, E. Hirabara, M. Imahariyama, and K. Komaki, "The evolving non-surgical ablation of breast cancer: MR guided focused ultrasound (MRgFUS)," Breast Cancer, 14, 55-58 (2007).   DOI
16 J. H. Hwang and L. A. Crum, "Current status of clinical high-intensity focused ultrasound," Proc. the 31st Annual International Conference of the IEEE EMBS. Minneapolis, MN, USA, 130-133 (2008).
17 J. E. Kennedy and G. ter Haar, and D. Cranston, "High intensity focused ultrasound: surgery of the future?" Br. J. Radiol. 76, 590-599 (2003).   DOI
18 E. A. Stewart, J. Rabinovici, C. M. C. Tempany, Y. Inbar, L. Regan, B. Gastout, G. Hesley, H. S. Kim, S. Hengst, and W. M. Gedroye, "Clinical outcomes of focused ultrasound surgery for the treatment of uterine fibroids," Fertil. Steril. 85, 22-29 (2006).   DOI
19 J. E. Kennedy, F. Wu, G. ter Haar, F. V. Gleeson, R. R. Phillips, M. R. Middleton, and D. Cranston, "Highintensity focused ultrasound for the treatment of liver tumours," Ultrasonics, 42, 931-935 (2004).   DOI
20 S. Madersbacher, M. Pedevilla, L. Vingers, M. Susani, and M. Marberger, "Effect of high-intensity focused ultrasound on human prostate cancer in vivo," Cancer Res. 55, 3346-3351 (1995).
21 F. Wu, Z. B. Wang, W. Z. Chen, J. Bai, H. Zhu, and T. Y. Qiao, "Preliminary experience using high intensity focused ultrasound for the treatment of patients with advanced stage renal malignancy," J. Urol. 170, 2237-2240 (2003).   DOI
22 F. Wu, Z. B. Wang, W. Z. Chen, J. Z. Zou, J. Bai, H. Zhi, K. Q. Li, F. L. Xie, C. B. Jin, H. B. Su, and G. W. Gao, "Extracorporeal focused ultrasound surgery for treatment of human solid carcinomas: early Chinese clinical experience," Ultrasound Med. Biol. 30, 245- 260 (2004).   DOI
23 L. L. Xiong, J. H. Hwang, X. B. Huang, S. S. Yao, C. J. He, X. H. GE, H. Y. Ge, and X. F. Wang, "Early clinical experience using high intensity focused ultrasound for palliation of inoperable pancreatic cancer," JOP J. Pancreas, 10, 123-129 (2009).
24 C. C. Wu, C. N. Chen, M. C. Ho, W. S. Chen, and P. H. Lee, "Using the acoustic interference pattern to locate the focus of a high-intensity focused ultrasound (HIFU) transducer," Ultrasound Med. Biol. 34, 137-146 (2008).   DOI
25 C. Bohris, W. G. Schreiber, J. Jenne, I. Simiantonakis, R. Rastert, H. J. Zabel, P. Huber, R. Bader, and G. Brix, "Quantitative MR temperature monitoring of highintensity focused ultrasound therapy," Magn. Reson. Imaging. 17, 603-610 (1999).   DOI
26 X. Zheng and S. Vaezy, "An acoustic backscatterbased method for localization of lesions induced by high-intensity focused ultrasound," Ultrasound Med. Biol. 36, 610-622 (2010).   DOI
27 J. Hindley, W. M. Gedroyc, L. Regan, E. Stewart, C. Tempany, K. Hynnen, N. Macdanold, Y. Inbar, Y. Itzchak, J. Rabinovici, K. Kim, J. F. Geschwind, G. Hesley, B. Gostout, T. Ehrenstein, S. Hengst, M. Sklair-Levy, A. Shushan, and F. Jolesz, "MRI guidance of focused ultrasound therapy of uterine fibroids: Early results," Am. J. Roentgenol. 183, 1713-1719 (2004).   DOI
28 N. McDannold, C. M. Tempany, F. M. Fennessy, M. J. So, F. J. Rybicki, E. A. Stewart, F. A. Jolesz, and K. Hynynen, "Uterine Leiomyomas: MR imaging-based thermometry and thermal dosimetry during focused ultrasound thermal ablation," Radiology, 240, 263-272 (2006).   DOI
29 E. S. Ebbini, H. Yao, and A. Shrestha, "Dual-mode ultrasound phased arrays for image-guided surgery," Ultrasonic Imaging, 28, 65-82 (2006).   DOI
30 A. Anand, D. Savery, and C. Hall, "Three-dimensional spatial and temporal temperature imaging in gel phantoms using backscattered ultrasound," IEEE Trans. Ultrason. Ferroelect. Freq. Contr. 54, 23-31 (2007).   DOI
31 P. D. Bevan and M. D. Sherar, "B-scan ultrasound imaging of thermal coagulation in bovine liver: log envelope slope attenuation mapping," Ultrasound Med. Biol. 27, 379-387 (2001).   DOI
32 P. D. Bevan and M. D. Sherar, "B-scan ultrasound imaging of thermal coagulation in bovine liver: frequency shift attenuation mapping," Ultrasound Med. Biol. 27, 809-817 (2001).   DOI