Browse > Article
http://dx.doi.org/10.4489/KJM.20210021

Production of an Anti-dementia Butyrylcholinesterase Inhibitor from Non-pathogenic Wild Yeast, Saccharomyces cerevisiae WJSL 0113  

Han, Sang-Min (Faculty of Biomedicine and Biotechnology, Paichai University)
Park, Seon-Jeong (Faculty of Biomedicine and Biotechnology, Paichai University)
Jang, Ji-Eun (Faculty of Biomedicine and Biotechnology, Paichai University)
Lee, Jong-Soo (Faculty of Biomedicine and Biotechnology, Paichai University)
Publication Information
The Korean Journal of Mycology / v.49, no.2, 2021 , pp. 243-248 More about this Journal
Abstract
In this study, screening of potent non-pathogenic wild yeast with high anti-dementia butyrylcholinesterase (BChE) inhibitory activity and production condition of a BChE inhibitor were described. Among 36 non-pathogenic wild yeasts, Saccharomyces cerevisiae WJSL 0113 showed the highest BChE inhibitory activity of 85.2%. The specific BChE inhibitor was maximally produced when S. cerevisiae WJSL 0113 was cultured at 30℃ for 48 h in a yeast extract-peptone-dextrose medium.
Keywords
Anti-dementia; Butyrylcholinesterase inhibitor; Saccharomyces cerevisiae WJSL 0113; Wild yeast;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Lee DH, Lee DH, Lee JS. Characterization of a new antidementia β-secretase inhibitory peptide from Rubus coreanus. Food Sci Biotechnol 2008;17:489-94.
2 Hwang JS, Im SB, Lee II, Kim TR, Kim DO. Effects of Opuntia ficus-indica var. saboten ripe fruits on protection of neuronal PC-12 cells and cholinesterase inhibition. Korean J Food Sci Technol 2016;48:86-91.   DOI
3 Han SM, Kim JY, Lee JS. Production of anti-dementia acetylcholinesterase inhibitor from Pleurotus ostreatus (Heuktari) and inhibitory effect on PC12 neuron apoptosis. Kor J Mycol 2019;47:337-46.   DOI
4 Bae SM, Han SM, Choi JM, Lee JS, Kim HK. Manufacturing of Korean traditional rice wine, Makgeolli, supplemented with strawberry and its physicochemical and microbial properties during fermentation. Kor J Mycol 2016;44:307-13.   DOI
5 Lee DH, Lee DH, Lee JS. Characterization of a new antidementia β-secretase inhibitory peptide from Saccharomyces cerevisiae. Enz Microbiol Technol 2007;42:83-8.   DOI
6 Lee DH, Lee JS, Yi SH, Lee JS. Production of the acetylcholinesterase inhibitor from Yarrowia lipolytica S-3. Mycobiology 2008;35:102-5.
7 Lee EN, Song JH, Lee JS. Screening of a potent antidementia acetylcholinesterase inhibitor-containing fruits and optimal extraction conditions. Korean J Food & Nutr 2010;23:318-23.
8 Lee SR, Kang HW, Kim ST, Lyu YS. The effects of anti-alzheimer in pCT105-induced neuroblastoma cell lines by radix polygalae and rhizoma acori graminei mixture extract. J Physiol & Pathol Korean Med 2003;17:1037-49.
9 Shin JW, Kim YH, Kim JH, Na KC, Lee JS. Manufacture of pear marc nuruk by Aspergillus oryzae and characteristics of makgeolli fermentation. Kor J Mycol 2013;41:255-60.   DOI
10 Jeong SC, Lee DH, Lee JS. Production and characterization of an anti-angiogenic agent from Saccharomyces cerevisiae K-7. J Microbiol Biotechnol 2006;16:1904-11.
11 Kim JH, Lee DH, Jeong SC, Chung KS, Lee JS. Characterization of antihypertensive angiotensin I-converting enzyme inhibitor from Saccharomyces cerevisiae. J Microbiol Biotechnol 2004;14:1318-23.
12 Kim JY, Lee SY, Han SM, Lee JS. Production of anti-dementia acetylcholinesterase inhibitors from the wild yeasts Saccharomyces cerevisiae WJSL0113 and Wickerhamomyces anomalus JSF0128. Kor J Mycol 2018;46:447-57.   DOI