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http://dx.doi.org/10.4489/KJM.20170025

Screening of Anti-inflammatory Compound-producing Wild Yeasts and Their Microbiological Characteristics  

Bae, Sang-Min (Department of Biomedicinal Science and Biotechnology, Paichai University)
Han, Sang-Min (Department of Biomedicinal Science and Biotechnology, Paichai University)
Lee, Jong-Soo (Department of Biomedicinal Science and Biotechnology, Paichai University)
Publication Information
The Korean Journal of Mycology / v.45, no.3, 2017 , pp. 212-223 More about this Journal
Abstract
To screen for potent anti-inflammatory compound-producing yeasts, we evaluated nitric oxide production inhibitory activities in RAW 264.7 macrophage cells using cell-free extracts from 182 non-pathogenic yeasts. Rhodotorula graminis YJ36-1 and Meyerozyma guilliermondii YJ34-2 showed high inhibitory activities of 57.4% and 47.0%, respectively. The microbiological characteristics of these yeasts were investigated. Rhodotorula graminis YJ36-1 formed ascospores and pseudomycelium. This species grew well at $25^{\circ}C$ in yeast extract-peptone-dextrose (YPD) medium, vitamin-free medium, and 5% NaCl-containing YPD medium. Meyerozyma guilliermondii YJ34-2 was an asporogenous yeast and did not form pseudomycelium. This strain also grew well at $30^{\circ}C$ in YPD medium, vitamin-free medium, and 5% NaCl-containing YPD medium.
Keywords
Anti-inflammatory; Nitric oxide inhibitor; RAW264.7; Wild yeast;
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Times Cited By KSCI : 20  (Citation Analysis)
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