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http://dx.doi.org/10.4489/KJM.2015.43.1.68

An Indole Alkaloid from the Fruiting Body of Boletus umbriniporus  

Lee, Yoon-Ju (Division of Biotechnology, Chonbuk National University)
Hwang, Byung-Soon (Division of Biotechnology, Chonbuk National University)
Song, Ja-Gyeong (Division of Biotechnology, Chonbuk National University)
Kim, Dae-Won (Division of Biotechnology, Chonbuk National University)
Woo, E-Eum (Division of Biotechnology, Chonbuk National University)
Lee, In-Kyoung (Division of Biotechnology, Chonbuk National University)
Yun, Bong-Sik (Division of Biotechnology, Chonbuk National University)
Publication Information
The Korean Journal of Mycology / v.43, no.1, 2015 , pp. 68-70 More about this Journal
Abstract
Mushrooms are valued as a nutritional food and also as an important source of useful medicinal components. They produce various secondary metabolites which have interesting biological activities and unique chemical structures. As part of our ongoing investigation on chemical constituents and bioactive components of Korean native mushrooms, compound 1, an indole alkaloid, was isolated from the fruiting body of Boletus umbriniporus. B. umbriniporus is characterized by its yellow flesh, which changes to pallid blue when exposed to air, and its chemical constituent has not been reported. Chemical structure of compound 1 was determined to be flazin on the basis of ESI-mass, $^1H$ NMR, $^{13}C$ NMR, $^1H-^1H$ COSY, HMQC, and HMBC analysis. This compound was isolated from the fruiting body of B. umbriniporus for the first time.
Keywords
Boletus umbriniporus; Flazin; Indole alkaloid; Mushroom;
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1 Chen YF, Kuo PC, Chan HH, Kuo IJ, Lin FW, Su CR, Yang ML, Li DT, Wu TS. ${\beta}$-carboline alkaloids from Stellaria dichotoma var. lanceolata and their anti-inflammatory activity. J Nat Prod 2010;73:1993-8.   DOI   ScienceOn
2 Tanaka JC, Silva CC, Oliveira AJ, Nakamura CV, Dias Filho BP. Antibacterial activity of indole alkaloids from Aspidosperma ramiflorum. Braz J Med Biol Res 2006;39:387-91.   DOI
3 Zhang JW, Gao JM, Xu T, Zhang XC, Ma YT, Jarussophon S, Konishi Y. Antifungal activity of alkaloids from the seeds of Chimonanthus praecox. Chem Biodivers 2009;6:838-45.   DOI   ScienceOn
4 Tang JG, Wang YH, Wang RR, Dong ZJ, Yang Lm, Zhenq YT, Liu JK. Synthesis of analogues of flazin, in particular, flazinamide, as promising anti-HIV agents. Chem Biodivers 2008;5:447-60.   DOI   ScienceOn
5 Wang YH, Tang JG, Wang RR, Yang LM, Dong ZJ, Du L, Shen X, Liu JK, Zheng YT. Flazinamide, a novel beta-carboline compound with anti-HIV actions. Biochem Biophys Res Commun 2007;355:1091-5.   DOI   ScienceOn
6 Macabeo AP, Vidar WS, Chen X, Decker M, Heilmann J, Wan B, Franzblau SG, Galvez EV, Aquinaldo MA, Cordell GA. Mycobacterium tuberculosis and cholinesterase inhibitors from Voacanga globosa. Eur J Med Chem 2011;46:3118-23.   DOI   ScienceOn
7 Park SS, Lee KD, Min TJ. Study on the screening and development of antibiotics in the mushrooms: the screening of bacterial and fungal antibiotics in basidiomycetes(II). Kor J Mycol 1995;23:176-89.
8 Dong ZJ, Wang F, Wang RR, Yang LM, Zheng YT, Liu JK. Chemical constituents of the fruiting bodies from the basidiomycete Suillus granulatus. Zhongcaoyao 2007;38:17-9.