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http://dx.doi.org/10.4489/KJM.2015.43.1.40

Biological Activities of Wild Sparassis crispa Extracts  

Kim, Eun-Jung (Department of Biomedical Laboratory Science, Sangji University)
Yoo, Kwan-Hee (Department of Life Science, Sangji University)
Kim, Yang-Sup (Sejong Institute of Data Analysis Co Ltd.)
Seok, Soon-Ja (Agricultural Microbiology Division, National Academy of Agricultural Science, RDA)
Kim, Jun-Ho (Department of Fine Chemistry and New Materials, Sangji University)
Publication Information
The Korean Journal of Mycology / v.43, no.1, 2015 , pp. 40-46 More about this Journal
Abstract
Physiological activities of solvent extracts of Sparassis crispa were investigated for fibrinolytic, thrombin inhibitory, anti-oxidative and anti-inflammatory activities. The fibrinolytic activity was the highest in ethyl acetate extract (2.03 plasmin units/mL) followed by butanol extract (0.70 plasmin units/mL). The ethyl acetate extract exhibited the highest anti-oxidative activity as assessed by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging rate with a value of 95.94%. The chloroform extract showed thrombin inhibitory activity up to 83.87%. The chloroform extract also showed the highest anti-inflammatory effects on the production of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. These findings suggest that Sparassis crispa may be a useful material for development of drugs and functional foods.
Keywords
Anti-inflammatory activity; Anti-oxidative activity; Fibrinolytic activity; Sparassis crispa; Thrombin inhibitory activity;
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Times Cited By KSCI : 9  (Citation Analysis)
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